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Biomedical subjects

A Horie

Publications and source records attributed to A Horie.

126 records · Page 7Linked to original sources
PubMedDate not supplied

Biological half-time in rats exposed to nickel monosulfide (amorphous) aerosol by inhalation.

This study reports the biological half-time of amorphous nickel monosulfide(NiS(A)) aerosol retained in rat lungs. Wistar male rats were exposed to NiS(A) aerosols (mass median aerodynamic diameter:4.0 microns) for a single 4 h exposure, or for 7 h/d, 5 d/wk for 1 mo. The average exposure concentrations were controlled at 107 mg/m3 for the single exposure and at 8.8 mg/m3 for the repeated exposures by a dust generator consisting of a continuous fluidized bed with an overflow pipe and a screw feeder. After the exposures, the nickel contents in the rat organs, blood, and urine were measured and histopathological examinations were performed. The biological half time of NiS(A) in rat lungs was 20 h, which was extremely shorter than 21 mo of green nickel oxide (NiO(G)). There were no malignant tumors in any of the exposure groups.

Aerosols↗
PubMedDate not supplied

Systemic necrotizing vasculitis with renal involvement accompanied by remarkable eosinophilia: a case with overlapping features of polyarteritis nodosa and allergic granulomatous angiitis.

A 71-year-old woman was clinically suspected of allergic granulomatous angiitis (AGA) because of preceding allergic diseases including bronchial asthma, remarkable eosinophilia (14,300/mm3), mononeuritis multiplex, positive rheumatoid factor, elevated serum immunoglobulin E, and eosinophilic inflammation of the kidney. Autopsy findings, however, were characterized of polyarteritis nodosa (PAN). Necrotizing angiitis was present in several organs except for the lung; focal and segmental glomerular lesions with crescent formation were observed in the kidney, and granuloma formation was not found. This case may be an intermediate type between PAN and AGA (an overlap syndrome) and provide useful information on the clinical entities of systemic necrotizing vasculitis.

Aged↗
PubMedDate not supplied

Globular cytoplasmic inclusion bodies in a metastatic hepatocellular carcinoma of the iliac bone.

Globular filamentous bodies are one of the well-known inclusion bodies in hepatocellular carcinoma. The article describes a 56-year-old man with an occult hepatocellular carcinoma in whom the first histologic diagnosis was made from a biopsy from bone. Ultrastructural examination showed many globular filamentous bodies similar to Mallory bodies. The ultrastructural findings and the diagnostic value of these filamentous bodies are discussed.

Bone Neoplasms↗