Prescribing in pregnancy. Epilepsy and anticonvulsant drugs.
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Biomedical subjects
Publications and source records attributed to A Hopkins.
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Several neurological syndromes, including syncope, convulsions, amnesia, transient ischaemic attacks and cerebral infarction, have been associated with mitral valve prolapse. It has been presumed that emboli may account for some of these. We report a case of retinal infarction in association with mitral valve prolapse.
Two patients reported that on walking they developed tingling and weakness of the legs and penile erections. The symptoms proved to be due to stenosis of the lumbar were canal, and were relieved by operative decompression.
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Capital costs are presently treated as pass-through payments under PPS. However, this situation is only temporary and by Oct. 1, 1986, HCFA must endorse a proposal to incorporate capital costs into the framework of PPS. Several methods have been suggested--a capital add-on approach, a modified pass-through approach, and variations of these two approaches. Looking at a case study hospital--a large urban teaching center--results show that the modified pass-through approach is the most advantageous, providing the largest cash flow.
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The analysis of the results of many well-designed, double-blind trials of anticonvulsant drugs has been unsophisticated. We draw attention to the nonrandom occurrence of seizures, which negates the simple comparison of average seizure frequency. We propose a method of taking into account clustering of seizures when deciding on the appropriate length of follow-up after introducing a new treatment. Deterministic and nondeterministic models were used to show why there may be reasons for sometimes using more than one drug in the treatment of epilepsy.
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Survey research into patient satisfaction has been responsible for developing a number of related concepts concerning the ways in which patients evaluate the health care that they receive. Recently doubts have been expressed as to the adequacy of this approach for understanding how patients anticipate and respond to medical encounters. This paper reports a study of patients attending neurological outpatient clinics. The results suggest that the conceptual framework deriving from patient satisfaction research provides only partial and sometimes misleading insights into the perspectives of the patients studied. The paper concludes that patients' varying concerns with regard to their illness need to be more directly considered in explaining different responses to medical consultations. This approach enables a more sensitive evaluation of health care from the patient's point of view.
We have investigated the possibility that a delay in long-loop (transcortical) reflexes might be responsible for the occurrence of drop attacks which occur in middle-aged women without disturbance of consciousness. We have not been able to confirm this suggestion. However, using simple Newtonian principles, we calculate how far the subject may fall before a long-loop reflex can be generated in the quadriceps muscle. We suggest that in some subjects tension cannot be generated sufficiently quickly to maintain the erect posture. This hypothesis provides a link between subjects who experience drop attacks due to overt muscle weakness and subjects without physical signs.
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Patients attending neurological clinics with headaches that proved not to be due to clearly defined structural disease were interviewed before and after the consultation and approximately one year later. Their expectations of the consultation were ill-formed. About two-thirds of the patients had fears about organic disease although few had psychiatric morbidity. These fears were generally dispelled by the consultation. About one-third of the patients were dissatisfied by the consultation, nearly all by what the neurologist said rather than by what technical procedures he did or did not undertake. Women with a long history of migraine, with significant psychiatric morbidity, and who had initiated the referral themselves were particularly likely to be dissatisfied. Although most patients were still having headaches one year later, visits to the general practitioner for this symptom had greatly declined.
A community sample of 94 adults with epilepsy were interviewed in their homes by a sociologist and a neurologist. Less than half of those who had worked full-time after the onset of their seizures could recall that their careers had been inhibited by their epilepsy, yet most felt 'at risk' and chose to conceal their condition from their employers or potential employers. Disadvantage in employment was found to be related both to a working class status and to a high rate of epileptic activity. We suggest that epileptics are prone to deny themselves career opportunities.
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