Search PubMed⌕ Search

Biomedical subjects

A Hollinger

Publications and source records attributed to A Hollinger.

At least 55 records · Page 3Linked to original sources
PubMed1982

Gastric emptying and postprandial duodenogastric reflux in pylorectomized dogs.

A two-marker technique was used to determine gastric emptying rate and postprandial duodenogastric reflux rate without transpyloric intubation. The fractional gastric emptying rate in five dogs with normal pylorus was 3.0 +/- 0.3 (SE) X 10(-2)/min. In three dogs with circular pylorectomy, it was 5.8 +/- 0.8 X 10(-2)/min (P less than 0.01). The duodenogastric reflux rates were 0.72 +/- 0.23 (SE) ml/min and 3.21 +/- 0.97 ml/min. (P less than 0.05). The percentage of the test meal that by to-and-fro movements across the pylorus was emptied more than once was 2.3 +/- 1.0 (SE) in normal dogs and 15.5 +/- 2.4 after pylorectomy (P less than 0.005). Because the higher emptying rate was accompanied by more to-and-fro movements, the amount of the meal remaining in the stomach, and thus net gastric emptying, was similar in both groups. It is concluded that pylorectomy increases both reflux rate and emptying rate. This effect on emptying can only be detected by a method that includes the measurement of to-and-fro movements across the pylorus. The pylorus thus appears to prevent postprandial duodenogastric reflux and to slow gastric emptying.

Animals↗
PubMed1981

Duodenogastric reflux in the fasting dog: role of pylorus and duodenal motility.

A two-marker technique was used to determine duodenogastric reflux in fasting dogs with normal or surgically modified gastroduodenal junctions. All nine dogs had an esophagostomy for gastric marker perfusion. The duodenal marker was given via a duodenal fistula. In two dogs a Heineke-Mikulicz pyloroplasty was performed, and in four dogs extramucosal circular pylorectomy was performed in addition. The mean fasting duodenogastric reflux rate in dogs with a normal pylorus was 1.1 +/- 0.5 (SE) ml/10 min; after pyloroplasty it was 1.6 +/- 0.3 ml/10 min (P greater than 0.1), and after pylorectomy it was 1.5 +/- 0.4 ml/10 min (P greater than 0.1). Simultaneous intraduodenal manometry revealed no relation between the interdigestive myoelectric complex and reflux. The marker technique for the measurement of reflux was validated by pharmacologically induced reflux. Subcutaneous injection of 0.1 mg of apomorphine increased the reflux rate tenfold. A transpyloric tube increased reflux rate fivefold. It is concluded that, in the fasting dog, phenomena such as retropulsive peristalsis are determinants of duodenogastric reflux and not the presence or absence of the pylorus and normal interdigestive motility.

Animals↗
PubMed1981

A quantitative assessment of duodenogastric reflux in the dog after meals and under pharmacological stimulation.

Duodenogastric reflux was measured in the dog by a double marker technique which does not interfere with the gastroduodenal junction. Duodenogastric reflux occurred both with a lipid and a protein meal. The gastric accumulation of duodenal contents was higher with fat than with protein because fat slowed gastric emptying. It was even higher with atropine because in addition to slowing gastric emptying atropine also increased the reflux rate. The effect of atropine was offset by a histamine H1 agonist.

Animals↗
PubMed1981

Quantitative assessment of duodenogastric reflux after vagotomy with or without pyloroplasty-A clinical investigation.

The experiment consists in intravenous infusion of 99mTc-Hepatobida, fractioned aspiration of the gastric juice by means of a tube and measurement of radioactivity in the aspirated liquid. Patients are fasting for at least twelve hours and tests are started early in the morning. 5 mCi of 99mTc-Hepatobida are injected intravenously. Thereupon gastric juice is collected by means of a gastric tube every ten min during 90 min. Duodenogastric reflux is provoked by installing 100 ml of Intralipid. Sampling of gastric contents is continued as above. Radioactivities in the aspirate are compared in five patients before operation, after truncal vagotomy with pyloroplasty, after highly selective vagotomy without pyloroplasty and after highly selective vagotomy without pyloroplasty. There is no typical pattern for either type of operation. We suggest that motor antral activity is more important than pyloric function.

Bile Reflux↗
PubMed1980

[Continent external duodenal fistula in the dog (author's transl)].

An established method for the experimental approach to the duodenum in the dog is the interposition of a segment of small bowel. However, the leakage of intestinal fluid causes unpleasant side effects. By the invagination within the intestinal segment as valve can be constructed which provides both continence and easy access.

Animals↗
PubMed1980

[Results of curative, distal resection of stomach neoplasms].

Between 1962 and 1971 there were operated 99 patients suffering from gastric cancer. From these, 83% could be controlled as long-term follow-up. The overall survival rate after one year was 68%, after three years 40% and after five years 36%. The patients with tumor-free lymph nodes showed a 5-year survival rate of 49% while of those with tumor-involved lymph nodes only 17% lived longer than five years. The survival rate, especially of older patients (above 60 years), showed with a distal gastric resection compared to a total gastric resection a significant lower postoperative mortality, a better quality of life and a better survival rate. A total gastric resection should only be indicated in cases in which a radical tumor resection could not be realized with a distal gastric resection.

Adenocarcinoma↗
PubMed1980

[Experience with the EEA stapler in colon anastomosis].

On the basis of 35 resections of the sigma of low anterior resections of the rectum, the outcome of conventional (13) and EEA stapler (22) anastomoses is analysed. The incidence of clinical or radiological insufficiencies is significantly lower in stapler anastomoses. Technical details important for a successful stapling procedure and the outcome of the anastomosis are discussed. The importance of the control for completeness of the tissue rings after removal of the purse-string suture is stressed. Regarding these technical details stapler anastomoses have proven to facilitate very low anterior rectal resections and to achieve less postoperative complications.

Aged↗
PubMed1980

[Late results after total gastrectomy and reconstruction by the Hunt-Lawrence-Ròdino method].

The operative technique to perform the jejunal pouch--a stomach substitute--according to Hunt-Lawrence-Rodinò is described. This operation should be employed in all cases in which a radical procedure is under consideration. The quality of life is much better than after simple esophago-jejunostomy. The 5-year survival after gastrectomy for carcinoma being 37% and 50% for Zollinger-Ellison syndrome, respectively, a somewhat longer operation is justified.

Gastrectomy↗
PubMed1979

[Proximal selective vagotomy with or without pyloroplasty?].

Proximal gastric vagotomy without drainage is the operation of choice for uncomplicated duodenal ulcer. There are few contraindications for PGV as uremia, diabetes, hypertension, age over 65 years and a history of splenectomy. Only in cases of severe pyloric stenosis or bleeding ulcer or perforation in the pyloric area, a pyloroplasty should be added. The Wangensteen pyloroplasty is a safe drainage procedure and especially recommended in case of extensive scarring of the pylorus.

Drainage↗
PubMed1977

[Liver resection in benign and malignant tumors].

Benign tumors of the liver, circumscribed hepatomas and solitary hepatic metastases from colonic cancer are treated by partial liver resection. In case of colonic cancer the hepatic metastasis is resected in a second operation. 20 cases of hepatic resections are reported. 10 right hepatic lobectomies, 1 left hepatic lobectomy and 9 minor resections were performed. Of the 11 patients treated by hepatic lobectomy, one (or 9%) died in the postoperative period (within 30 days after operation). Of the other 9 patients undergoing minor resections there was no death.

Carcinoma, Hepatocellular↗
PubMed1976

[Late complications of the intestine after radiotherapy of bladder carcinoma].

Immediate reactions of the intestines during or after radiotherapy of the pelvis are very common. Later complications requiring surgical intervention are seldom found. Out of 101 patients with bladder carcinomas, we observed 4 with severe irreversible intestinal changes. These had been operated and had received post-operative radiotherapy. On 3 patients a sigmoid stenosis had to be resected under the protection of a colostomy. On the fourth patient an ileovesical fistula was closed primary.

Adult↗