The correlation between the subjective sensation of nasal patency and nasal resistance (NR) to airflow was examined in a large population. The subjective estimation was assessed by a visual analogue scale and the NR by active anterior rhinomanometry in 158 subjects. Evaluation and statistical analysis--including correlation and regression analysis--were computerized. A statistically significant correlation was found between the subjective and objective values (r = -0.301, p < 0.001). There was no correlation between the parameters if the groups with or without nasal obstruction were evaluated apart. In 84% of the cases, the narrower side of the nose was identified with both the objective and the subjective methods. Statistically significant correlations were exhibited between the subjective and the objective measures if unilateral NR and the ipsilateral subjective values were related to each other (n = 316, r = -0.476, p < 0.001), in both cases, on the side of the higher and the lower NR. The best correlation was found on the side of the higher NR, that is when nasal breathing is more impeded. Subjective estimation seems to be sufficient only to indicate the more obstructed side of the nose independently from the dimensions of the NR values.

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PubMedDate not supplied

Airflow resistance monitoring in laryngotracheal stenosis. Laser surgery in bilateral vocal cord paralysis.

Thirty-seven patients with laryngotracheal stenosis were treated within the last 3 years at the ENT Department of the Semmelweis University of Medicine in Budapest. Unilateral laser arytenoidectomy was performed in the group with pure vocal cord paralysis. Airflow resistance of the upper respiratory tract was measured with a modified Rhinotest MP 500 active anterior rhinomanometer through the tracheostomal orifice before and after the operation. The mean preoperative resistance was 0.951 Pa/cm3/s, which was reduced to 0.487 Pa/cm3/s postoperatively. In the successfully decannulated cases the postoperative resistance value averaged 0.360 Pa/cm3/s. The resistance limit (including nasal and pharyngeal resistances) seems to be 0.50 Pa/cm3/s.

Adult↗

PubMedDate not supplied

Prognostic significance of P53 histochemistry and DNA histogram parameters in head and neck malignancies.

BACKGROUND: The aim of the study was to determine the role of quantitative pathological parameters in prognosis of head and neck malignancies. MATERIALS AND METHODS: 51 head and neck squamous cell carcinoma patients were examined for mutant p53 gene expression (45 out of 51 patients) by immunohistochemistry and for cellular DNA-content (44 out of 51 patients) using digital picture analyzer. Statistical analysis was performed using BMDP package. RESULTS: No correlation with prognosis was found for age, sex, localization, T-classification and therapy. There was significant relationship between N-status and overall survival (p = 0.0008). No correlation was found with overall and disease-free survival for either histologic type or grading. P53: No significant correlation was detected with overall survival. A relationship was found between mutant p53 and metastasis-free time (p = 0.06). Ploidy: There were no significant differences between aneuploid and euploid tumors for either disease-free or overall survival. Synthetic (S)-phase fraction: A correlation was found for both survival rates (p = 0.029) and metastasis-free time (p = 0.05). Polyploid fraction (PF): correlation was shown for both overall survival (p = 0.0128) and metastasis-free time (p = 0.0038). CONCLUSION: There is correlation between p53 overexpression and metastatic potential and there is a significant relationship between SPF and PF value and prognosis (metastasis-free and overall survival) of head and neck cancer.

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