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Biomedical subjects

A Hey

Publications and source records attributed to A Hey.

At least 19 recordsLinked to original sources
PubMed1995

Dichotomy of the T cell response to Leishmania antigens in patients suffering from cutaneous leishmaniasis; absence or scarcity of Th1 activity is associated with severe infections.

The T cell response was studied in 25 patients suffering from cutaneous leishmaniasis caused by Leishmania major with severe (n = 10) and mild (n = 15) disease manifestations. Peripheral blood mononuclear cells (PBMC) from the patients were activated by sonicates of Leishmania promastigotes (LMP) and amastigotes (LDA), and the surface protease gp63. The proliferative responses to Leishmania antigens were lower in patients with severe disease than in patients with mild disease (P = 0.01-0.05), and such a difference was not observed in the response to purified protein derivative of tuberculin (PPD) or tetanus toxoid (TT). LMP-induced interferon-gamma (IFN-gamma) production was lower in patients with severe than in patients with mild disease (P < 0.05). When the IL-4 and IFN-gamma responses of each patient were considered, two response patterns were observed in the cultures activated by the Leishmania sonicates. One response pattern was characterized by high production of IFN-gamma without production of IL-4 (a Th1-like pattern), the other was characterized by low IFN-gamma levels which in most cases were associated with IL-4 production (not a Th1-like pattern). These patterns could not be distinguished when the cells from the same donors were stimulated by TT and PPD. The percentages of patients with a Th1-like response pattern after stimulation by LMP in patients with severe and mild disease manifestations were 30% and 80%, respectively. This difference was statistically significant (P = 0.034).

Animals↗
PubMed1995

[Development of adenocarcinoma in a retrorectal pre-sacrococcygeal hamartoma].

Among the different pathologic structures of the presacrococcygeal space retrorectal cystic hamartomas are uncommon lesions. These cysts are most likely derived from remnants of the embryonic tailgut although an association to teratomas may exist. We describe the clinicopathologic features of a retrorectal cystic hematoma with malignant transformation in a 60 year old female patient. The literature is reviewed and etiology, diagnosis and operative management are discussed.

Adenocarcinoma, Mucinous↗
PubMed1988

[Vascular eccrine giant spiradenoma--a case report with histology and immunohistology of a rare variant of benign sweat gland tumors].

Giant vascular eccrine spiradenoma (GVES) is a rare variant of benign tumors of the sweat glands, which differs from common eccrine spiradenoma in both its size and vascularity. Clinically as well as macroscopically, this intradermal or subcutaneous encapsulated tumor might be mistaken for an angiomatous lesion or thrombosis. Histological examination reveals clearly delimited "cords" showing two types of cells, prominent blood-filled cavities and extensive hemorrhages. According to immunohistochemical findings, the epithelial cells contain cytokeratin, protein S-100 and carcino-embryonal antigen (CEA). Like the endothelial cells of vessels, some of the luminal epithelial cells also bind Ulex europaeus lectin; however, they do not show factor VIII-associated antigen.

Adenoma, Sweat Gland↗
PubMed1988

Trichoblastic fibroma (fibromatoid trichoepithelioma).

Six examples of so-called trichoblastic fibroma occurred in five females and one male. The age of the patients ranged from 46 to 70 years (mean: 61 years). Three tumours were on the back, one each on the left gluteus, right skull and left thigh; they were present one to 20 years and varied in size from 1.8 to 6 cm. The tumour nodules were easily shelled out at operation, and the macroscopic aspect was that of fibroma. Although there seems to be a close relationship to trichoepitheliomas, this tumour deserves a separation from classical conventional trichoepitheliomas and differs from these by size, consistency, involvement of deeper tissues, nodular character, unusual location, age of patients and additional histopathologic findings. In our opinion, these rare tumours may also be classified as fibromatoid trichoepitheliomas.

Aged↗
PubMed1988

Tartrate-resistant acid phosphatase containing cells in nodular fasciitis, proliferative fasciitis, and proliferative myositis.

Five cases of nodular fasciitis, three cases of proliferative fasciitis, and one case of proliferative myositis were investigated by tartrate-resistant acid phosphatase (TRAP) histochemistry on conventional paraffin-embedded material. In all cases varying numbers of enzyme-positive cells were detected. Cytological investigations revealed the presence of small round cells, elongated spindle cells, medium-sized mono- or binucleated cells, and multinuclear giant cells, the latter resembling osteoclasts. However, the typical ganglion-like cells were TRAP-negative in almost all tests. The TRAP-pattern may help to differentiate nodular fasciitis and allied lesions from inflammatory pseudotumours or organising haematomas, as the latter do not contain TRAP-positive cells. As TRAP appears to be a marker for a special population of phagocytizing and non phagocytizing histiocytes, nodular fasciitis and its proliferative variants may be assumed to be fibrohistiocytic tumorous conditions.

Acid Phosphatase↗
PubMed1987

[Arterial fibromuscular dysplasia as an unexpected cause of death in adults].

In a 38-year-old woman, arterial hypertension was diagnosed a few weeks before her death. She died unexpectedly before a diagnostic clarification of the cause was possible. Autopsy revealed an arterial fibromuscular dysplasia with manifestation in both common iliac arteries, both renal arteries, the celiac trunk and the splenic artery. Both renal arteries displayed stenotic dissecant aneurysms which were the cause of the arterial hypertension. As a rare and lethal complication of fibromuscular dysplasia, a ruptured saccular aneurysm was found in the splenic artery. Histologically, the vascular alterations were a combination of medical fibromuscular dysplasia (type II) and periarterial or adventitial fibroplasia (type III). On the basis of the immunohistochemical detection of abundant lysozyme-positive cells, the periarterial fibroplasia appears to be a secondary chronic granulating and cicatricial reaction and not a separate form of fibromuscular dysplasia.

Adult↗
PubMed1987

Comparison of bronchoalveolar lavage helper/suppressor T-cell ratios in sarcoidosis versus other interstitial lung diseases.

In order to compare the frequency of elevated lymphocyte proportions and elevated Leu3/Leu2 (helper/inducer to suppressor/cytotoxic) ratios in sarcoidosis with those in clinically similar interstitial lung diseases (ILDs), bronchoalveolar lavage (BAL) lymphocyte proportions and Leu3/Leu2 ratios were determined for 20 patients with sarcoidosis and 30 patients with other (non-sarcoidosis) ILDs [cryptogenic fibrosing alveolitis (seven), lung connective tissue disease (seven), extrinsic allergic alveolitis (four), lymphoproliferative disease (two), and asbestosis (ten)], as well as in eight control subjects. BAL lymphocyte proportions were elevated above control values in 19 (95%) patients with pulmonary sarcoidosis (mean value 36 +/- 3%) but also in 12 (39%) patients with non-sarcoidosis ILDs (mean value 17 +/- 4%). Leu3/Leu2 ratios were over 2.5 in 15 (75%) of the sarcoidosis patients (mean ratio 4.4 +/- 1). In all control subjects, however, and in all but one of the non-sarcoidosis groups, Leu3/Leu2 ratios were below 2.5 (p less than 0.001 for each compared to sarcoidosis patients). Helper/suppressor ratios over 2.5 are found in the majority of our sarcoidosis patients and, unlike raised lymphocyte proportions alone, are not commonly seen in other ILDs, suggesting that evaluation of BAL helper/suppressor cell ratios may be of value in the investigation of patients with ILD.

Adult↗
PubMed1987

Is arterial blood pressure a powerful factor in sodium excretion?

The control of sodium balance is very complex. Many different factors act together in the regulation of renal sodium excretion. Some investigators suggest that arterial blood pressure has a direct effect on urinary excretion of sodium and water. They report that whenever arterial pressure increases, urinary excretion of sodium and water also increases. This phenomenon is called pressure diuresis and natriuresis. It has been stated that an increase in arterial pressure of about 30% can increase urinary output as much as three-fold or more. Many studies, especially in the isolated, perfused kidney, support this idea. However, it is not clear how important this mechanism is under physiological conditions.

Animals↗
PubMed1985

[Bacterial infection of an Ionescu-Shiley bioprosthesis. Morphologic studies].

Bacterial inflammation associated with artificial cardiac valves is a rare complication after valve replacement but is burdened with a high lethality. Whereas in the case of mechanical valves the infection involves the body's own tissues, bacterial colonisation of valves made of prepared biological material can also occur. The morphology of the bacterial inflammation was examined in a case of early postoperative endocarditis. Although the bacterial infection in the paravalvular tissues resulted in a purulent inflammation, the Ionescu-Shiley-bovine bioprosthesis remained free of inflammatory cells despite extensive vegetative bacterial growth.

Aged↗