[Residual urine in the healthy child].
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Adolescent↗
Biomedical subjects
A Hesse
Publications and source records attributed to A Hesse.
Transthyretin Leu 68 in a form of cardiac amyloidosis.
A form of transthyretin (TTR)-related cardiac amyloidosis was previously described in a German patient. Electrophoretic analysis of plasma TTR showed the presence of an electrically neutral variant. We have now characterized the variant transthyretin by comparative peptide mapping, aminoacid and DNA sequencing procedures. A new mutation in TTR with a substitution of leucine for isoleucine at position 68 of the monomer is described.
Amino Acid Sequence↗
[Infection-induced urinary calculi in children; current therapeutic schedule and prevention of recurrence].
Infection stones have an outstanding position in childhood urolithiasis. In non-infection stones one can mostly find a certain--for example metabolic--causes of stone formation. In infection stones, the urease-producing and thus urea-cleaving properties of some gram-negative bacteria are responsible for alkalization of the urine and lead especially in combination with disturbances of urine transport to the staghorn calculi. Therefore in such children early diagnosis, adequate therapy and consequent maintenance is the crucial point for good life quality in future. Preliminary condition for therapeutic success is a close coworking between pediatric nephrologist, pediatric urologist, family doctor and parents.
Bacterial Infections↗
[The mechanical effects of shock waves in extracorporeal shock wave treatment of calcific tendinitis--an in vitro model].
OBJECTIVE: Various studies have shown the benefit of the extracorporal shock wave therapy in the treatment of the calcific tendinitis. It was the aim of this study to examine the energy needed to disintegrate a calcific deposit. METHOD: By using the in vitro model of the pig shoulder the mechanical effects of different energy levels and impulse rates on the calcifying deposits are investigated. RESULTS: The results are showing the energy- and impulse-depending effect of the shockwaves. The disintegration of the implanted "bonn-stones" with development of an large amount of fragments smaller then 1000 microns requires an energy of 0.42 mJ/mm2 and between 2000 and 3000 impulses. CONCLUSIONS: According to the experimental results a instant mechanical effect on the calcifying deposits using the ordinary parameter is unlikely. The absorption of the calcifying deposits in likely induced through cellular clearing function. Clinical trials confirmed the good therapeutical results after two sessions with at least 1500 pulses and an energy of 0.28-0.30 mJ/mm2.
Animals↗
Primary peritonitis in previously healthy children--clinical and bacteriological features.
A prospective study of cases of primary peritonitis in children at the Korle-Bu Teaching Hospital, Accra, was undertaken to find diagnostic clinical and aetiological features of the disease. Seventeen children, 15 females and two males, diagnosed as primary peritonitis underwent laparotomy with peritoneal toiletting. Peritoneal exudate and high vaginal swabs (HVS) were taken under anaesthesia for bacteriological analysis. Patients were followed up for one month. Thirteen patients (70%) were aged between 6 to 10 years. Presentation was early (65% presented in less than 48hrs of onset of symptoms). The commonest presenting feature were fever (100%) and abdominal pain (100%) in the absence of headache (100%). All had classical signs of diffuse peritonitis. There was leucocytosis in 15 cases (88%). No bacterial growth was obtained in 50% of cases cultured. Pneumococcus was the commonest organism isolated (33.3%). Of the 7HVS taken, 4 did not yield any bacterial growth and 2 grew escherichia coli but no pneumococcus. There was no correlation between the bacteriological findings of the peritoneal exudate and the HVS. Post-operative complications were few, insignificant and there was no mortality recorded. Sixty five percent (11/17) of cases could be predicted from the clinical symptoms and signs. The results of this study do not support any aetiological theory of causation.
Abdominal Pain↗