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Biomedical subjects

A Herruzo

Publications and source records attributed to A Herruzo.

At least 19 recordsLinked to original sources
PubMed1992

Adrenal hormones in human follicular fluid.

Considerable evidence indicates that adrenal hormones may affect gonadal function. To assess the role of some adrenal hormones in human follicular fluid and their relationship with the ability of the oocyte to be fertilized and then to cleave in vitro, cortisol and dehydroepiandrosterone sulfate were measured in follicular fluid obtained at the time of oocyte recovery for in vitro fertilization from cycles stimulated by clomiphene citrate, human menopausal gonadotropin and human chorionic gonadotropin. Thirty-six follicular fluid containing mature oocyte-corona-cumulus complexes and free of visible blood contamination were included in this study. There was no significant difference in follicular fluid dehydroepiandrosterone sulfate concentration between follicles with oocytes which did or did not fertilize (5.1 +/- 1.1 vs 5.8 +/- 2.0 mumol/l). However, follicular fluid from follicles whose oocytes were not fertilized had levels of cortisol significantly higher than those in follicular fluid from follicles containing successfully fertilized oocytes (406.0 +/- 75.9 vs 339.2 +/- 37.0 nmol/l; p < 0.005). No significant correlations were found between rates of embryo cleavage and cortisol and dehydroepiandrosterone levels in follicular fluid. We conclude that cortisol levels in follicular fluid may provide an index of fertilization outcome, at least in stimulated cycles by clomiphene citrate, human menopausal gonadotropin and human chorionic gonadotropin.

Adrenal Cortex Hormones↗
PubMed1992

Insulin and insulin-like growth factor I in follicular fluid after induction of ovulation in women undergoing in vitro fertilization.

This study was undertaken to evaluate the relationship between concentrations of insulin and insulin-like growth factor I (IGF-I) in follicular fluid and fertilization and cleavage of human oocytes fertilized in vitro. The concentration of oestradiol, progesterone, luteinizing hormone, follicle-stimulating hormone, testosterone, insulin and IGF-I was determined in 36 follicular fluids, free of visible blood contamination and containing mature oocyte-corona-cumulus complexes, obtained from 12 women undergoing in vitro fertilization. Follicular development was induced by clomiphene citrate and human menopausal gonadotrophin, and follicular aspiration was performed 35 h after an ovulatory dose of human chorionic gonadotrophin. Concentrations of IGF-I were significantly higher in follicular fluids associated with mature oocytes that fertilized and cleaved, than in follicular fluid associated with mature oocytes that did not fertilize (P < 0.001). There was no difference in the concentration of insulin between follicular fluids from which fertilized oocytes were obtained and those with oocytes that remained unfertilized. No significant correlations were found between rates of embryo cleavage, concentrations of insulin and IGF-I. Multiple linear regression analysis demonstrated that the concentrations of IGF-I in follicular fluid were predicted statistically by a negative regression coefficient for the concentration of testosterone, and by a positive regression coefficient for the concentration of progesterone in follicular fluid. No candidate variable was included in the model to predict concentrations of insulin. These data suggest an important role for IGF-I in the mature follicle.

Adult↗
PubMed1992

Primary non-Hodgkin lymphoma of the vulva.

We report a rare case of non-Hodgkin lymphoma located in the vulva. The diagnosis was supported by the cytological anomalies in material obtained by fine needle aspiration. The tumor was removed with wide excision, and the patient was alive and in good health ten months after surgery.

Aged↗
PubMed1978

[Spermatogenic dysfunction and gonadotrophins (author's transl)].

The authors try to demonstrate a relation between the number of immature cells of germinal origin in sterile men's sperm and plasmatic gonadotrophin levels of the same patients. Plasma FSH, LH, testosterone and 17 beta-estradiol were assayed in two groups of male patients with teratospermia. Results were compared with those obtained in a control group of normal men. Hypophyseal gonadotrophins level is higher in men whose spermatogenesis is defective than in normal men. It is suggested that these results might support the hypothesis that a defect in inhibin synthesis would be responsible for raised gonadotrophins.

Estradiol↗
PubMed1977

Multi-tailed spermatozoa in a case with asthenospermia and teratospermia.

A case is presented of an infertile male whose spermatozoa showed low mobility, a high percentage of irregular large heads and a variable number of tails (between 0 and 4). In the spermatozoa with several tails each axoneme, surrounded by its own outer fibres and mitochondrial sheath, arose from its own basal plate. Throughout the middle piece of every spermatozoon all the axonemes were arranged in parallel and were enclosed by the same plasma membrane. Usually, at the beginning of the principal piece, the axonemes became separated. At this level each of them constituted a different tail. In most spermatozoa the fine structure of the tail or tails was normal. The alterations of the inner structure of the tail or tails was normal. The alterations of the inner structure of the flagellum observed in some spermatozoa (enlargement of the fibrous sheath, duplication of the outer fibres and of some peripheral doublets) were independent of the number of tails present. In some cases, an intracytoplasmic coiling of the tail or tails could be observed.

Adult↗
PubMedDate not supplied

[Lack of the central pair of axial filaments in a case of short-tailed spermatozoa human teratospermia (author's transl)].

A case of short-tailed human spermatozoa is presented in a patient with severe teratospermia. The middle piece was generally short, showing abundant cytoplasmic droplets, disruption of the mitochondrial sheath and absence of some coarsed fibers. The majority of spermatozoa showed enlargement of the principal piece, reduplication of proliferation of the fibrous sheath, and disorganization as well of the axial filament complex as of the coarsed fibers. An abnormal great number of microtubules and coarsed fibers were frequently randomly scattered throughout the cytoplasmic droplet. A further abnormality, consisting in the lack of the central pair of axial filaments was relevant in a 70 p. 100 of spermatozoa. This latter abnormality could be or not associated with the former alterations.

Adult↗