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Biomedical subjects

A Hernigou

Publications and source records attributed to A Hernigou.

At least 55 records · Page 3Linked to original sources

[Angioscanner analysis using Imatron C100 in 44 cases of hepatic tumors].

We studied 44 patients with focal benign (n = 13) or malignant (n = 31) liver tumors prouved by histology or follow-up. The flow mode was acquired by electron beam CT (EBCT) after injection (35 cc at 6 ml/sec): 20 slices with a 400 ms exposure time. We looked for abnormal vessels and density curves inside the tumor, liver and aorta. We describe arterial vascularization in most cases (type 1) and particularly in all the hepatocarcinomas (n = 15) associated with abnormal vessels, and also in rare tumors (n = 4). For benign lesions like angiomas (n = 9) we showed surrounding the mass arterial vascularization in add to the typical aspect (type 3); for nodular hyperplasia (n = 3) arterial blush was associated with the last part of the tumoral curve at the same level as liver. Most often metastasis (n = 13) had no central vascularization and a slight peripheral density increased (type 2). Flow mode by EBCT allows a good density curves analysis particularly at arterial time.

Adult↗

[Measurement of global and separate renal blood flow using cine-computed tomography].

EBCT flow study offer a promising new approach to measure the renal blood flow. In vitro and in vivo studies were performed to resolve methological problems such as checking the linear relation between contras concentration and Hounsfield units or determination of the Treshold used for the mapping. First measurements of renal volumes and flow performed in patients showed expected values.

Aged↗

[Cardiac metastasis disclosed by ventricular tachycardia. Diagnosis by echocardiography and ultrafast tomodensitometry].

The authors report the case of a right ventricular metastasis presenting with ventricular tachycardia and underline the usual diagnostic problems of secondary cardiac tumours, the symptoms of which are often unspecific and late. The appearance of a cardiac arrhythmia in the absence of known cardiac disease should raise the possibility of a cardiac metastasis in patients with malignant disease. The reported case also illustrates the diagnostic value of non-invasive cardiac imaging techniques (echocardiography and ultra-fast computerised tomography) in this context.

Aged↗

[Biliary cystadenocarcinoma. Apropos of a case].

Biliary cystadenocarcinoma is rare biliary ductal neoplasm, usually occurring in middle-aged women, which arises in a healthy liver, with a better prognostic than other malignant tumors of the liver. We report a new case documented by echography, CT scan and MR. Echography showed multiple heterogeneous and septate masses with fluid-fluid level and dilatation of the intra-hepatic biliary ducts. CT showed multilocular cystic masses with internal septa and papillary excrescences showing contrast enhancement and no calcification. MR displayed a rather intense and variable signal in some parts of the masses on T1 weighted images, flasching on T2 weighted images, corresponding to a hemorrhagic fluid, confirmed by surgery. On T1 weighted images after gadolinium administration, the masses were less well visualized.

Bile Duct Neoplasms↗

Coronary calcification and its relation to extracoronary atherosclerosis in asymptomatic hypercholesterolemic men. The PCV METRA Group.

BACKGROUND: The prevalence of coronary calcifications and extracoronary plaques was studied in patients with asymptomatic hypercholesterolemia. METHODS AND RESULTS: Ultrafast computed tomography for coronary calcification (presence or absence: calcium score) and echographic assessment of carotid, aortic, and femoral plaques were performed in 111 hypercholesterolemic men: 65% had coronary calcification, 72% had extracoronary plaque. The two lesions were associated as: 1) compared with subjects without coronary calcification, those with calcification had a higher prevalence of aortic (p less than 0.05) and femoral (p less than 0.01) plaque and of two diseased sites (p less than 0.05); 2) the prevalence of coronary calcification was higher in the presence than in the absence of aortic (p less than 0.05) or femoral (p less than 0.01) plaque and higher in two (p less than 0.01) and three diseased (p less than 0.05) sites than in no diseased site; 3) the calcium score was higher in the presence than in the absence of carotid (p less than 0.05), aortic (p less than 0.05), or femoral (p less than 0.001) plaque, higher in two (p less than 0.001) and three diseased (p less than 0.05) sites than in no diseased sites, and higher in two (p less than 0.01) than in one diseased site; and 4) the calcium score correlated with femoral plaque (p less than 0.001). Overall, the presence of two or three diseased extracoronary sites versus no or one diseased site showed a power of 78% for predicting coronary calcification. Coronary calcium score correlated with age (p less than 0.01) and triglycerides (p less than 0.05). CONCLUSIONS: The close relation between coronary calcium and extracoronary plaques suggests that echography of extracoronary vessels could aid in the screening of coronary atherosclerosis in high-risk, asymptomatic individuals.

Adult↗

[Hypertension has no effect on coronary calcifications in asymptomatic patients with hypercholesterolemia].

Since calcium in coronary artery walls is considered as an indicator for atherosclerosis, we used ultrafast computed tomography to quantify it non invasively in 111 hypercholesterolemic men. They were selected at worksite by a cholesterol screening program, had total cholesterol (TC) above 5.2 (6.88 +/- 0.82, SD) mmol/l, were aged from 30 to 63 (46 +/- 5 years), had never been treated with lipid lowering or antihypertensive drug, and had no clinical coronary heart disease. Body mass index, blood pressure, smoking and other serum lipids as HDL cholesterol, triglyceride (TG) were evaluated. Calcium score of proximal coronary arteries was calculated on 30 contiguous 3 mm slices from areas and peak density of calcium lesions. The mean score was 30 +/- 69 and ranged from 0 to 440. A zero score was found in 39 subjects who differed from the 72 others only by TG levels (1.44 +/- 0.60 vs 1.85 +/- 0.80; p < 0.05). A multiple regression analysis showed that elevated calcium score was associated independently to age (F = 6.6; p < 0.05) and TG (F = 6; p < 0.05) but not to blood. Thus 65% of these asymptomatic subjects had a non-zero calcium score in coronary arteries. Elevated calcium score was influenced independently by age and triglyceride level, but not by other risk factors, such as blood pressure. This potential adverse effect of moderate triglyceride elevation on large coronary arteries merits attention in the assessment of the risk of coronary heart disease.

Adult↗

[Ultrafast computed tomography and measurement of the left ventricular volume].

Ultrafast computed tomography is a method of acquiring cardiac tomographic images 8 mm thick of high resolution in a very short time (about 50 ms). It is particularly well adapted to evaluation of the anatomy and quantification of the volume of the left ventricle. Acquisition of the image is initiated by the R wave of the electrocardiogram. Short axis or long axis views of the heart may be recorded. There are usually 12 short axis tomographic cuts from the apex to the base and for each there are 13 acquisitions in the RR cycle at 58 ms intervals. The half circulation time must be determined beforehand as 50 cc of contrast medium have to be injected peripherally to visualise the cardiac chambers. The contrast medium enhances the endocardium and papillary muscle borders enabling semi-automatic contour tracings. End diastole and end systole are easily determined from the 13 acquisitions in the cardiac cycle, and the wall motion of the left ventricle can be analysed using a cineloop facility. Akinesia, dyskinesia and even wall thickness can be determined. After tracing the endocardial contour, the microprocessor calculates the surface of the enclosed area, and the volume of this simple cylinder can be derived by multiplication of the thickness of each slice. The total volume at each of the 13 instances is obtained by summation. End diastolic, end systolic volumes and ejection fraction can thereby be determined. Left ventricular mass may also be evaluated by tracing the epicardial border.(ABSTRACT TRUNCATED AT 250 WORDS)

Cardiac Volume↗

[Peroperative echography in 14 cases of pancreatic insulinoma and gastrinoma].

Fourteen cases of endocrine tumors (10 insulinomas and 4 gastrinomas) were to studied by intraoperative ultrasonography (IOU). Localization was established by preoperative ultrasonography in 1/14, by CT scan in 1/11, by arteriography in 6/12 and by pancreatic venous sampling in 7/8. Tumor size ranged from 0.5 cm to 2.5 cm. Manual palpation was positive in 10/14. The tumor was accurately and completely localized by IOU in 9/10 insulinomas: the one false negative was probably due to micro-adenoma. The intrapancreatic tumor was localized only in 1/14 gastrinomas. Intraoperative sonography localized lymph nodes in all cases. One distal pancreatectomy was improperly performed because of an accessory spleen. After reviewing 59 other cases in the literature, we propose: a) to abandon venous sampling in insulinomas because of adequate performance of IOU; b) to use IOU as a complementary investigative method along with other preoperative methods of localization in gastrinoma.

Adenoma, Islet Cell↗

Ultrasound during surgery of the carotid artery.

Operative ultrasonography is very useful in carotid artery surgery--First to show before the reconstruction the site, the degree and the shape of the lesions--second after the reconstruction to appreciate its quality. In our 26 cases, reintervention was performed in five cases but only 3 have had a second reconstruction. Sensitivity of this method is very high, and this must be taken into consideration before any repeat surgery.

Carotid Artery Diseases↗

Repetitive echoes in ultrasonography of the diaphragm demonstrated by cadaver studies.

For some years past, strange and seemingly inexplicable images frequently appear during sonographic examination of the area below the diaphragm. In order to explain these mysterious phenomena we carried out anatomical experiments. We observed the appearance of such enigmatic images no matter what the kind of probe was used and found that in every case the appearance of a phantom image over the diaphragm signifies the existence of a true image situated elsewhere. It is always possible with necessary adjustments to locate the formation responsible for the phantom images, which are no longer mysterious.

Diaphragm↗

[Should colonic anastomoses be inspected radiologically?].

Routine early radiologic review examinations were conducted in 100 patients after colocolic or colorectal anastomosis. Postoperative course was assessed as clinically uncomplicated in 77 cases, a barium enema producing normal images in 67 and abnormal images in 10 cases, and recovery operations were not necessary. The course was more difficult in 23 patients: recovery operation to repair a gap was needed in 9 cases, while results were evaluated as satisfactory in 14 with 3 false negatives. Recovery operations (including 6 for fistula) in 9 patients followed acute clinical manifestations. Clinical evaluation is therefore of primary importance, a barium meal being justified only when intra-abdominal complications are suspected, while recognizing the risk of false negative results for this examination.

Aged↗

[Contribution of intraoperative echography in hepatic metastases].

Current research is devoted to the most appropriate treatment for hepatic metastases. Intra-operative ultrasonography is very valuable for assessing metastatic lesions, their exact number and their topography in relation to surgical landmarks such as the fissures and the hepatic pedicles. Surgery can then be adapted (metastasectomy, segmentectomy, hepatectomy) in relation to the peripheral parenchyma and the remaining parenchyma. The authors present the results of intra-operative ultrasonography performed at the hôpital Broussais in the diagnosis and treatment of 41 hepatic masses. In every case, the treatment of choice was surgical resection and chemotherapy was only administered as second line therapy in cases of failure.

Humans↗

[Peroperative ultrasonics in excision of renal and ureteral calculi by the surgical approach. Apropos of 30 cases].

Ultrasound imaging was conducted in 30 patients during operation for removal of renal and ureteral stones, in most cases after contact radiography with small sterile films, and in all cases before opening the renal pelvis to avoid penetration of an air bubble into the intrarenal excretory tract. Each bubble may, because of its weak acoustic impedance, provoke total reflection of the waves simulating the image of a stone. Ultrasound provides data on cortical projection of calculi, the thickness of the parenchyma and the echoless avascular zones. All complex calculi (from Staghorn to caliceal types) should be investigated by ultrasound since it allows economy of time and reduced risks of excision of calculi. All stones greater than 1 mm give a hyperechogenic image with a cone shadow, the only differential diagnoses being air bubbles and intraparenchymatous calcification. Nonrecognition of calculi 1 mm in diameter is acceptable insofar as this type of caliceal or pyelic calculus may be excreted spontaneously. Ultrasound imaging during operation provides marked economy in time, of particular value during nephrotomy with pedicle clamping. Time is saved as a result of the three-dimensional detection of stones. Results in 30 cases showed a sensitivity of 97% for the method with excellent specificity, with only one false negative (residual microlithiasis) and one false positive (air bubble).

Humans↗