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Biomedical subjects

A Hermant

Publications and source records attributed to A Hermant.

At least 19 recordsLinked to original sources
PubMed1998

Detection of benzo[a]pyrene-DNA adducts from leukocytes from heavy smokers.

Benzo[a]pyrene is a cigarette smoke component that is metabolized in the human body to the diol-epoxide derivative benzo[a]pyrene-trans- 7,8-dihydrodiol-9,10-epoxide (BPDE-I), which is the final carcinogen. BPDE-I binds covalently to DNA, producing BPDE-I-DNA adducts. A competitive immunoenzymetric assay was used to measure BPDE-I-DNA adducts in blood samples from 58 heavy smokers, 32 men and 26 women, attending a smoking cessation clinic. Cigarette consumption was evaluated based on urinary continine levels. None of the subjects worked in jobs involving exposure to polycyclic aromatic hydrocarbons (e.g., benzo[a]pyrene). Concentrations of BPDE-I-DNA adducts varied with cigarette consumption, ranging from 10.00 to 28.20 fmol/50 micrograms of DNA.

7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide↗
PubMed1990

[Labor under peridural anesthesia. Experience at the Maternity Center of the Amiens CHRU].

The study has been carried out on 476 epidural deliveries. 69 per cent of the patients were satisfied. Amongst the 31 per cent of unsatisfied, most claimed that the analgesia was not sufficient, mainly due to delayed re-injections. Instead of a continuous administration, the authors prefer the use of a bolus which is better adapted to the different times of labour. 80 per cent of the patients who had a caesarian delivery under epidural anaesthetic were very satisfied. The efficacy of the re-injection for post-operative analgesia is also to be noted (92 per cent success). Finally, whatever the stage of perfection of the epidural technique, it is always better to associate the latter with a good psychoprophylaxis.

Adult↗
PubMed1989

[Bourneville's disease of the bones or metastasis? Apropos of a case].

Tuberous sclerosis or Bourneville's disease is a phakomatosis with common but paucisymptomatic bone localisations. Some osseous lesions, of osteosclerotic type, can be radiologically diagnosed as primary or secondary malignant disorders. We describe a case of Bourneville's disease with bone involvement, radiologically characterized by osteosclerosis areas of the spine and the pelvis. Interestingly, bone scintiscan was normal. The absence of primary malignancy, the stability of control bone X-ray films, the clinical status and the family history, together with the pathognomonic radiological feature of the hands support the diagnosis of tuberous sclerosis with bone involvement.

Aged↗
PubMed1989

[Hydatid cyst of the thymus. Apropos of a indigenous case].

Hydatid cysts located in the thymus are extremely rare. Only 8 cases were reported in a recent publication, and all concerned patients from endemic areas. The case presented here is original in that it concerns a patient living in Picardy.

Adult↗
PubMed1987

[Use of intrapleural doxycycline via lavage-drainage in recurrent effusions of neoplastic origin].

27 patients (17 F, 10 M) with a mean age of 65 +/- 11 years and suffering from recurrent pleural effusions were treated with locally administered Doxycycline by lavage-drainage to achieve pleural symphysis (17 adeno-carcinomas, 3 large cell carcinomas; 3 epidermoid cancers; 3 non-Hodgkin's lymphoma; 1 small cell carcinoma). The solution used was a dilution of 50 ml doxycycline in 250 cc of isotonic saline. 22 of the 27 patients could be evaluated long term, 5 were lost to follow up, of whom two had recurred straight away despite local treatment. An immediate response was obtained in 23 out of the 28 patients (85%). Later the absence of recurrence was seen in 90% of the patients evaluated. The incidence of antimitotic therapy did not seem to be the determining factor in the 7 patients who received this in parallel. The duration of drainage was 11 +/- 6 days, the local treatment was well tolerated in the majority of cases. The use of the technique of lavage-drainage of doxycycline could be an alternative in those patients with a malignant pleural effusion whose general condition contra-indicates a symphysis under pleuroscopy.

Aged↗
PubMed1983

Intracranial pressure changes in patients with head trauma during haemodialysis.

Intracranial hypertension and acute renal failure are frequent complications in polytraumatized patients with head trauma. This paper deals with the evolution of intracranial pressure during haemodialysis in two cases of traumatic coma. Significant changes in intracranial pressure were noted. Increase of intracranial pressure during haemodialysis was 7.6 mmHg for the first patient and 4.6 mmHg for the second patient. Prophylactic measures are discussed.

Acute Kidney Injury↗
PubMed1978

[Value of right cardiac microcatheterization in the prescription and control of oxygen therapy in chronic respiratory insufficiency].

The authors studied 24 patients with chronic respiratory insufficiency divided in 2 groups, one of them subjected to long lasting oxygen therapy. They studied the correlations between the variations of hemodynamic and non dynamic parameters registered during a previous assay of oxygen therapy and those observed during the evolution so as to deduct criteria of prescription of a long lasting oxygen therapy. They stress the importance of microcatheterism at the beginning. On the other hand if it suggests the indication for a controlable oxygenation, the ponctual assays of oxygen therapy, such as defined, present no interest where the appreciation of later successes of a long term oxygen therapy is concerned.

Blood Gas Analysis↗
PubMedDate not supplied

[Long-term results of intermittent ventilatory assistance for 74 severe obstructive chronic respiratory insufficient patients (PaCO2 greater than 50 Torr) ventilated for more than a year (author's transl)].

From 1967 to 1978, home assisted ventilation (HAD) was applied to 74 severe chronic respiratory insufficient patients (67 COPD-7 restrictive). These patients used volume generators through mouth piece, except 3 of them who had a tracheostomy. The main results of this study are a highly statistically significant decrement (P less than 0,001) of the hospitalization durations and of the frequency of ARF, as well as an improvement of the survival duration in front of a non-tested group, and a significant decrease of haematocrit (less than 0,05) and P.V.R. (P less than 0,01). But blood gases and functional tests are not statistically different. Age (greater than 55 years) and delay after first ARF (greater than 2 years) when starting HAD are considered as pejorative factors.

Blood Gas Analysis↗