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Biomedical subjects

A Hare

Publications and source records attributed to A Hare.

10 recordsLinked to original sources
PubMed1992

Endothelin-1 stimulates phospholipid hydrolysis and prostaglandin F2 alpha production in primary human decidua cell cultures.

The regulation of prostaglandin (PG) production by the uterine decidua may be an important mechanism controlling the onset and maintenance of human parturition. The present in vitro study has evaluated the potential for endothelin-1 (ET-1) to activate cell signalling and PGE2 alpha production in human primary decidua cell cultures. ET-1 stimulated a dose-dependent increase in inositol phospholipid hydrolysis and PG precursor release as evidenced by respective increases in [3H] inositol monophosphate accumulation and [14C] arachidonate release from radiolabelled decidua cells. PGF2 alpha production was increased in some but not all cell preparations in response to ET-1 alone. Pretreatment of decidua cells with interleukin-1 beta (IL-1 beta) enhanced PGF2 alpha production but not arachidonate release in response to ET-1. These in vitro observations support a possible role for ET-1 in the regulation of decidual PG production during parturition.

Cells, Cultured↗
PubMedDate not supplied

The effect of gynecological surgery on sexual desire.

This study compared the impact of surgery on sexual desire in women who had undergone hysterectomy with women whose nongynecological surgery was of a similar status. Women aged 30 to 65 completed mailed questionnaires including the Sexual Desire Questionnaire, Hurlbert Index of Sexual Desire, and the Sexual Desire Inventory. Other areas assessed were affect, mood awareness, sexual anxiety, and androgen levels. Analysis of the questionnaire measures showed no differences in sexual desire for gynecological versus nongynecological surgery, or across the different types of hysterectomy. There was no relation between the level of androgens and the women's sexual desire levels. The implications of these findings are discussed with regard to the potential impact of surgery on sexuality, as well as future research in the area.

Adult↗
PubMedDate not supplied

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Attitude of Health Personnel↗