Search PubMed⌕ Search

Biomedical subjects

A Hajek-Rosenmayr

Publications and source records attributed to A Hajek-Rosenmayr.

32 records · Page 2Linked to original sources
PubMed1986

[Mixed lymphocyte culture as a compatibility test for bone marrow transplantation].

The reactions in mixed lymphocyte culture (MLC) between family members from 35 healthy families and 80 families of potential bone marrow recipients are shown. From the low MLC reactions seen in 128 pairs of HLA identical siblings, the limit of "Negative Reaction in Mixed Lymphocyte Culture" valid for our own laboratory can now be defined. The importance of mixed lymphocyte culture as a histocompatibility test for bone marrow transplantation is discussed.

Bone Marrow Transplantation↗
PubMed1985

[Anti-T in children].

In the serum of 245 newborn children, 165 elder children, and 50 grown-up persons, the antibody against the antigen T (Thomsen-Friedenreich-antigen, Transformation-antigen, T-receptor) has been determined. In 24,8% of the newborn, it was possible to find anti-T, which might be a cause of so far unclear hemolysis in this age. The investigation of sera from children between 1 and 17 years has shown, that anti-T is already present in children aged one year and reaches the level it usually has in grown-up people at the age of 4.

Adolescent↗
PubMed1985

[Cold antibodies].

Cold agglutinins and the antigens they react with as well as their significance for blood transfusion are reviewed. Cold auto-antibodies, their possible causes and their clinical relevance are described. The chemical nature of the somewhat similar molecular structures to which these antibodies are directed also are discussed.

Agglutinins↗
PubMed1983

[Lymphocyte stimulation in the primed lymphocyte typing test by as yet unknown HLA-linked antigens (WP-alleles)].

Lymphocytes from HLA-identical unrelated donors often show positive stimulation in the mixed lymphocyte culture, possibly caused by alleles of HLA-linked, but not yet defined gene loci. In order to investigate such determinants lymphocytes from HLA-DR identical individuals were primed and tested in the PLT system. Family and population data indicate that such antigens exist and can be detected in vitro.

Alleles↗
PubMed1983

[A new variant of blood group B].

In a turkish patient, a B variant was detected alongside a normally developed A antigen. It was classified as a strong Bx.

ABO Blood-Group System↗
PubMed1982

[Bone marrow transplantation for aplastic anemia--initial results in 8 patients].

8 young patients (aged 11 to 23 years) with severe aplastic anaemia received bone marrow grafts from their HLA-identical, MLC-non reactive siblings. All patients had received repeated transfusions previously and had been unsuccessfully treated with corticosteroids (7 out of the 8 patients) and/or anabolic drugs (4 out of the 8 patients). In order to prevent graft rejection 5 patients received donor buffy coat cells after the marrow infusion and 3 patients underwent total body irradiation with 400 rad prior to the marrow transplantation. 5 patients are alive, 3 patients died. Death occurred from Candida septicaemia (day 4 after transplantation), left ventricular failure (day 14) and graft versus host reaction of the gut (day 85). The 5 living patients are in a very good state of health 30 to 166 days after transplantation. 4 patients already have normal blood cell counts. 2 of the surviving patients developed a transient GVH-reaction of the liver. One patient had a mild GVH-reaction of the skin on day 130.

ABO Blood-Group System↗
PubMed1982

[Anti-T in newborn infants].

IgM (Immunoglobin M) antibodies to the antigen T (Thomsen-Friedenreich antigen, transformation antigen) were detected by normal agglutination technique in the serum of 7 out of 73 newborn children. Neither the mother's anti-T titre, nor the quantity of IgM and IgG (Immunoglobulin G) in the sera of mother and child was correlated with the anti-T in the newborn's serum. The significance of the newborn's anti-T for the serological diagnosis of a polyagglutinability caused by bacterial infection is discussed.

Adult↗
PubMed1982

[Reactions of primed lymphocytes (PLT) and their genetic determination (author's transl)].

Lymphocytes of one family member, if cultured in a primary culture with HLA haploidentical lymphocytes of another family member are primed by the foreign HLA haplotype. Primed lymphocytes can recognize cells bearing the priming haplotype in a secondary culture. The kinetics of this reaction (primed lymphocyte typing, PLT) and its genetic regulation were investigated in one family with a HLA-DR homozygous, HLA-D heterozygous member, one family with two HLA-D homozygous probands, one family with a recombination within the HLA system and in three normal families.

Epitopes↗
PubMed1981

[The significance of mixed lymphocyte culture and mitogen-stimulated culture for kidney transplantation (author's transl)].

In order to detect HLA-D identity or incompatibility, MLC tests were performed in 21 recipient-donor combinations before kidney transplantation (20 cadaver donors, one living related donor). In 20 cases, the MLC reaction was positive (R.R. greater than 10%). 13 of these patients rejected the transplant during the first three months after transplantation. One case was observed in which the MLC reaction between recipient and donor was negative. In this case, the graft has been functioning for more than a year. The lymphocytes of 7 kidney graft recipients were investigated in mitogen-stimulated lymphocyte cultures. In some cases, rejection crises were recognized in the test on the basis of a significantly enhanced reactivity of mitogen-stimulated lymphocytes. When no increase of proliferation was detected in the cultures, a rejection crisis became most improbable. One crisis failed to be detected and 6 false positive reactions occurred.

Antibody-Dependent Cell Cytotoxicity↗
PubMed1980

[Genetic control of mixed lymphocyte culture].

Eighteen healthy families were HLA typed with highly specific cytotoxic antisera; 10 of them were also HLA-DR typed. All of them were tested in the mixed lymphocyte culture. Two different methods of mixed lymphocyte culture-with respect to the number of cells used-were compared. The influence of D and DR antigens on mixed lymphocyte culture is discussed. A rather rare finding was that two unrelated people were homozygous for DR, but not for D and, hence, different with respect to their D and DR antigens. Seven individuals, among them two pairs of identical siblings, were found to be homozygous for HLA-D and HLA-DR. The possibility of using them as typing cells for the alleles of the HLA-D locus was discussed.

Adult↗