Biomedical subjects
A Hahn
Publications and source records attributed to A Hahn.
[Cryosurgical treatment of precancerous cheilitis abrasiva].
Between 1984 and 1988, 44 patients suffering from cheilitis abrasiva praecancerosa were treated with cryosurgery using a nitrous oxide cryoprobe. A single treatment proved sufficient in 35 patients (80%). 9 patients (20%) developed a recurrent lesion 4 to 28 months after cryosurgery. All recurrences appeared within the first year. On account of the recidivity of the disease, we recommend a careful follow-up of the patients. On the other hand, cryosurgery has the advantage that it can be applied in elderly persons as well as in patients with concomitant internal diseases. In pracancerous lesions, the common drawbacks of a surgical therapy such as diminution of the lower lip and impairment of the superficial sensitivity can be avoided with the help of this technique. Invasive carcinomas of the lower lip, however, should not be treated with cryosurgery.
Self-injury in psychiatric in-patients.
Suicide and self-injury in-patients were identified on the basis of a retrospective content analysis of special incidence reports completed the preceding year at an urban state psychiatric hospital. Select clinical and biodemographic variables were then examined, and in order to determine the importance of these variables in the prediction of incident severity, a multiple regression analysis was performed. Schizophrenic patients were found to be significantly over-represented among both the self-injury and suicide patients.
[New aspects of diagnostic criteria in BERA tests].
The purpose of the presented work was to investigate the relationship between the length of I-III and I-V intervals during BERA examinations on the intensity of the stimulus in healthy subjects. Furthermore to assess the normal range of the maximum length of I-III and I-V intervals. Twenty-seven subjects aged 15-57 years, incl. 10 men, were examined. The stimuli were 100 us clicks, the repeating rate was 30/s, the stimulation intensity 0-85 dB nHL. The examination was made after administration of diazepam or rohypnol. TDH 49 earphones were used. Into the external auditory meatus on the examined side an electrode of the authors' own design in the shape of an open tube was introduced. The length of I-III and I-V intervals depended on the intensity of stimulation. The differences of mean values of the length intervals at stimulation intensities of 65 dB nHL and 45 dB nHL were statistically significant: p less than 0.02 for interval I-III and p less than 0.0001 for interval I-V. We take as the upper borderline of the normal length of intervals I-III approximately 2.8 ms and of intervals I-V 4.7 ms, if the latency of wave I is smaller than 2.5 ms. When the latency of wave I is greater, even longer I-III and I-V intervals may be still normal.
[Dusodril in the ambulatory care of inner ear disorders].
The author discusses causes of disorders of the internal ear. He describes the tactics of treatment used in his department and gives an account of the therapeutic effect of the drug. In the subsequent parts of the paper results are quoted which were achieved during treatment of a total of 82 ambulatory patients. Dusodril is comparable with other preparations used in disorders of the internal ear. According to the author's observation it influences the symptomatology of the internal ear in the following order: dizziness hypacusia, tinnitus.
[Comprehensive diagnosis of tumors of the statoacoustic nerve].
The authors describe first the diagnosis procedure in tumours of the statoacoustic nerve, and analyze the reasons of their late detection. In the submitted paper they analyze in detail the applied examination methods. Consistent with data in the literature, they state that the greatest contribution to diagnosis is that of objective audiometry computed tomography has the final word in diagnosis; the authors proved by CT in a group of 37 examined patients in 21 a neurinoma of the statoacoustic nerve or another expansive lesion of the posterior cranial fossa.
Immunohistochemistry (S 100, KL 1) and human papillomavirus DNA hybridization on morbus Bowen and bowenoid papulosis.
In this study 55 paraffin embedded samples defined as Bowen's disease or bowenoid papulosis were investigated with antibodies against S 100 protein and keratins (KL 1). S 100-positive cells were quantified and related to defined section area of the epidermal compartment by computer-assisted image analysis. The density of S 100-positive cells was compared with normal skin and was particularly related to growth patterns and keratinization of the different lesions under study. S 100-positive dendritic cells were found to be reduced overall in bowenoid lesions when compared with normal skin. Lesions with high counts of S 100-positive dendritic cells most frequently showed a solitary growth pattern with highly conserved architecture and differentiation and no tendency to stromal invasion. In contrast, cases with low counts of S 100-positive cells very often showed multifocal development, a high degree of architectural disturbance and dedifferentiation. In this group, stromal invasion (cases of invasive carcinoma associated with Bowen's disease) was seen more often. Interestingly, this latter group of cases also revealed a peculiar keratin pattern. Frequently, the basal cell layer was decorated with KL 1 antibody, which usually recognizes only suprabasaly located keratinocytes. No differences between Bowen's disease and bowenoid papulosis were found in terms of densities of S 100-positive dendritic cells and keratin pattern. In our experience, extragenital Bowen's disease and genital Bowen's disease can not be distinguished on purely morphological grounds or with the immunocytochemical approach presented here. Interestingly, when employing in situ hybridization with HPV 16 probes three of seven samples of genital Bowen's disease harboured HPV 16 DNA, whereas six cases of extragenital disease were negative.
[Vasoactive drugs in the treatment of inner ear disorders].
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[Principles of the educational process at the department of otorhinolaryngology at the Charles University Medical School].
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The cellular receptor (CD4) of the human immunodeficiency virus is expressed on neurons and glial cells in human brain.
The expression of the CD4 antigen in normal human brain was investigated in parallel by immunohistochemical and Northern blot analyses. With anti-CD4 antibodies detecting different epitopes of the molecule, CD4+ neurons were defined in the cerebellum, thalamus, and pons. CD4+ glial cells were identified in the thalamus and pons. CD4-specific mRNA was detected in all three subareas and in the hippocampus, while other subareas were negative. The CD4+ cells were negative with anti-T cell antibodies (anti-CD2 and anti-CD8), as well as with antimonocyte antibodies (M-M 522 and M-M 42).
Attentional and perseverative impairment in two cases of familial fatal parkinsonism with cortical sparing.
The neuropsychological findings in twin brothers with familial fatal Parkinsonism are reported. Post-mortem examination had shown extensive pathology in basal ganglia and brainstem, but not in the cerebral cortex. Although both showed average intelligence three months prior to death, they had impairment on a sorting task and in serial attention span. Some possible neural mechanisms are discussed.
[Postural nystagmus in acute vestibular disorders].
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[Superficial fibrosarcoma of the face].
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Geometrical resonances in a high-injection-current nonequilibrium state of superconductor-normal-metal contacts.
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[In vitro studies on Geliperm Dry as a vehicle for antibiotics and antiseptics in local burn therapy].
Geliperm is a synthetic skin substitute, consisting of polysaccharid-polyacrylic plates. It is available as a soaked or a dried form (Geliperm dry). Geliperm dry can be soaked in antibiotic or antiseptic solutions. The in vitro inhibition of bacterial growth has been measured. The optimal concentrations have been evaluated. Geliperm dry soaked in antibiotic or antiseptic solutions can be used in the treatment of burns, but does not replace early excision of burned tissue or infected necrosis.
[Diagnosis of tumors of the statoacoustic nerve].
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A reinterpretation of the effect of temperature and water content of the inspired air in exercise-induced asthma.
To compare the importance of water loss with heat loss in the mechanism of exercise-induced asthma (EIA), we conditioned the air inspired during exercise to the same water content (Wi) while changing its temperature (Ti), and vice versa. We calculated separately the amount of heat and water required to bring the inspired air to alveolar conditions. Ten asthmatics ran for 8 min on 4 occasions in an environmental chamber. The air was conditioned to a Ti of 9 to 10 degrees C or 35 degrees C, with a Wi of 9 to 10 mg H2OL-1. The airway response to exercise was not significantly different when Ti varied by 25 degrees C, but the amount of water required to saturate the inspired air remained the same. However, the amount of heat required was significantly greater with cooler air (p less than 0.005). We conclude that it is the osmotic and not the cooling effects induced by the vaporization of water that is the more important factor determining EIA.