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Biomedical subjects

A Habior

Publications and source records attributed to A Habior.

32 records · Page 2Linked to original sources
PubMed1981

Effect of D-penicillamine on liver glutathione.

D-penicillamine is believed to protect against liver injury induced by certain chemicals. This view is based on the assumption that penicillamine is a structural analogue of cysteine, methionine, and congeners which protect against liver injury, perhaps by preventing GSH depletion, and that penicillamine also prevents GSH depletion. Our data indicate on the other hand that penicillamine actually depletes GSH and in animals may predispose to rather than prevent hepatic damage.

Animals↗
PubMedDate not supplied

[Caffeine blood concentration as an indicator of liver damage in patients with cirrhosis--correlation with Child's classification].

In 25 patients with cirrhosis fasting caffeine blood concentration was determined and the results were compared with Child's liver function sufficiency score. The caffeine blood concentrations in patients were higher than those in healthy controls (p less than 0.0001). Differences in comparison with controls were the more evident the greater was the degree of liver damage. Caffeine concentrations correlated well with the score indicating the sufficiency of the organ according to Child (R = 0.61; p = 0.002).

Adult↗
PubMedDate not supplied

[Primary biliary cirrhosis--analysis of clinical material].

The analysis is presented of 67 patients with primary biliary cirrhosis treated in the years 1971-1988. The group consisted of 60 women (89.5%) and seven men (10.5%). Presenting symptoms were mostly itching (66%) and jaundice (12%). The time between the onset of the first symptoms and the diagnosis was three years, on the average. Autoantibodies to mitochondria were present in 86% of patients. In 27% of cases markers of HB virus infection were found. Cholelithiasis was present in 19 patients (28%). Primary biliary cirrhosis was diagnosed with delay. Third degree of histological changes was observed in 38.8% of cases and in 18% of patients it was already fourth degree. Eighteen patients (27%) died after six years, on the average, from the onset of symptoms. The direct causes of death were, most frequently, liver failure and haemorrhage from oesophageal varices.

Adult↗
PubMedDate not supplied

[Ultrasonographic images of liver neoplasms--comparison with histopathological findings].

Ultrasound pictures taken in 100 patients with histologically confirmed primary of metastatic neoplasms of the liver were analysed retrospectively. The most frequent were hyperechogenic foci (43%). Hypoechogenic foci were found in 33% of the patients whereas mixed changes in the liver scans (hyper- and hypoechogenic) in 22%. Thirty seven per cent of the hyperechogenic foci were attributable to metastatic process. Hypoechogenic disorders were most frequently due to the primary cancer of the liver (20%). Mixed lesions were mainly produced by the cancer of large intestine and liver (41% and 27%, respectively). Metastases into the liver produced all three types of ultrasound pictures. The obtained results confirm the opinion that ultrasound picture of metastatic liver tumours is not suitable for the diagnosis of the type and origin of the neoplasm.

Adult↗
PubMedDate not supplied

[Plasma clearance of cholic acid in patients with chronic diseases of the liver].

The diagnostic value of 14C-cholic acid plasma clearance following oral administration was evaluated. 14C-cholic acid clearance was 1223 +/- 267 mL/min. per 1 square meter in the control group without liver disease. Significantly lower values (p less than 0.001) were obtained in the patients with chronic hepatitis (694 +/- 137 mL/min. per 1 square meter) and liver cirrhosis (332 +/- 156 mL/min. per 1 square meter). Sensitivity of the 14C-cholic acid clearance test was 100% while specificity--80%. A 3-year follow-up has shown that this test is of high prognostic value in patients with liver cirrhosis.

Adult↗
PubMedDate not supplied

Thrombin clotting time and fibrin polymerization in liver cirrhosis.

The thrombin clotting time and the fibrin polymerization test were performed in 64 patients with liver cirrhosis. Each test was made with thrombin diluted with 150 mmol/l sodium chloride and 25 mmol/l calcium chloride. The thrombin-in-NaCl clotting time was found to be prolonged in 39% of cirrhotic patients, whereas fibrin polymerization was defective in 65% of them. Dilution of thrombin with calcium chloride diminished the number of abnormal results of both tests in patients with liver cirrhosis. Among the performed tests most sensitive test proved to be the polymerization of fibrin induced by thrombin diluted with sodium chloride.

Adult↗