The role of the foetal pituitary in the susceptibility of the foetus to adrenal necrosis induced by 7-hydroxymethyl-12-methylbenz(a)anthracene.
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Adrenal Glands↗
Biomedical subjects
A H Wyllie
Publications and source records attributed to A H Wyllie.
Studies on the endocrine control of the rat foetal thymus.
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Adrenal Glands↗
Growth of in vitro cultured Landschütz ascites tumour in normal and resistant mice.
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Animals↗
Detection of human Ha-ras transcripts in tumor cells by in situ hybridization.
We demonstrate the development of a method for identification of human Ha-ras transcripts in cytological and histological preparations of rodent fibroblasts by RNA-RNA in situ hybridization. Fibroblasts, expressing human Ha- ras at high or a very low level, provide a biological model system to optimize in situ hybridization. For rapid detection we used the radiographic signal from cell smears, in directly overlaid x-ray film. Certain pretreatments of slides are shown to increase nonspecific probe binding. The methods described can be used for rapid detection of oncogene expression in small numbers of cultured cells, without prior extraction and purification of their RNA.
Genes, ras↗
The biology of cell death in tumours.
The principal objective of this article is to present evidence for the numerical and biological importance of cell death in tumour growth and regression. Much of this death has the morphology of apoptosis, a process observed elsewhere in biology in a variety of circumstances. Recent studies on the mechanism of apoptosis in non-neoplastic cells suggest that a relatively small number of specific intracellular changes are involved. Two of these are described: endonuclease activation within the nucleus, which coincides with the characteristic morphological changes there, and altered expression of surface carbohydrates, which may be responsible for the swift recognition and phagocytosis of apoptotic cells. It seems probable that similar events occur during the apoptosis of tumour cells. Further knowledge of the control of these endogenous mechanisms for effecting cell death could lead to powerful new means of controlling the growth of tumours.
Animals↗