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Biomedical subjects

A H Thomas

Publications and source records attributed to A H Thomas.

At least 19 recordsLinked to original sources
PubMed2001

Accommodative esotropia: an unrecognized cause of hemifacial spasm in children.

Pediatric hemifacial spasm can be a sign of an intracranial tumor. We examined two females, ages 2 and 6 years, who presented with hemifacial spasm as an early sign of accommodative esotropia. Initial ophthalmologic examination disclosed high hyperopia without detectable esotropia. Both children developed an intermittent esotropia over the following month. In the first child, the hemifacial spasm resolved concurrent with the onset of amblyopia. In the second child, spectacle correction produced immediate cessation of the spasms. In both children, squinting to avoid diplopia produced an overflow facial movement that manifested as hemifacial spasm. Accommodative esotropia should be considered in the differential diagnosis of pediatric hemifacial spasm.

Amblyopia↗
PubMed2000

Divergence insufficiency.

PURPOSE: Divergence insufficiency is an unusual form of strabismus with esotropia and diplopia only at distance and single binocular vision at near. This retrospective case series describes the diagnosis and treatment of 7 patients and differentiates this clinical entity from other conditions. METHODS: Seven healthy patients aged 9 to 41 years who developed acquired esotropia only at distance were treated with unilateral or bilateral medical rectus recession. RESULTS: All patients had resolution of diplopia, although one patient initially treated with unilateral medial rectus recession required a second recession of the other medial rectus muscle. CONCLUSIONS: Divergence insufficiency is a distinct clinical entity in otherwise healthy patients, which can be successfully treated by unilateral or bilateral medial rectus recession.

Adolescent↗
PubMed1993

A new approach to electrical safety testing of electromedical equipment.

The "New Approach" to electrical safety testing in Sir Charles Gairdner Hospital (SCGH) is based on the results and experience we have obtained in carrying out such tests for a period of over twenty years. Until recently our testing was carried out according to the annual procedures as described in Standards Australia recommendations. Test protocol changes have, however, now been made since it seemed from our records that we had been carrying out testing to an extent not justified by our test results. The paper describes the safety testing programme now in place at SCGH. This programme has resulted in substantial reduction in the testing time without, in our opinion, compromises in safety. The main elements in electromedical equipment test procedures are:- Acceptance tests In-Service tests Tests after repair We have found that the main consumer of time in electrical safety testing, aside from the test procedure itself, is gaining access to the equipment. This can be particularly difficult in areas where equipment is in constant use, e.g. in CCU, ICU, Renal Dialysis, Operating Theatres, etc. We have developed an earth integrity meter for the purpose of checking medical equipment without the need to disconnect it from the mains supply or from the patient. By means of this device, together with our new testing protocol, access problems have been largely eliminated.

Electricity↗
PubMed1992

[Regional anesthesia by the caudal route in adults. Apropos of 56 caudal blocks].

Caudal anaesthesia was described in 1901 but is now essentially used for paediatric surgery. From their experience of 56 caudal blocks in adult patients scheduled for pelvic surgery or endoscopy, the authors discuss the value of this technique. The anatomical and physiological basis and the main guidelines of caudal anaesthesia are recalled through some references.

Adult↗
PubMed1991

The international standard for teicoplanin.

An international standard for teicoplanin has been established on the basis of a collaborative study. There were five participating laboratories in five countries. The activity of the contents of each ampoule of the international standard for teicoplanin is defined as 51,550 IU of teicoplanin.

Anti-Bacterial Agents↗
PubMed1991

Team up for safety.

Explore the source record for details and available documents.

Attitude of Health Personnel↗
PubMed1990

The International Standard for Netilmicin.

An International Standard for Netilmicin has been established on the basis of a collaborative assay. There were five participating laboratories in five countries. The activity of the contents of each ampoule of the International Standard for Netilmicin is defined as 4810 IU of netilmicin.

Analysis of Variance↗
PubMed1987

Chromatographic methods for the analysis of vancomycin.

Four thin-layer chromatographic systems were developed for the separation of vancomycin, related antibiotics and degradation products. Bioautography was suitable for detecting trace amounts of biologically active components. High-performance liquid chromatography was used to examine the composition of vancomycin and other glycopeptide antibiotics and to monitor the stability of vancomycin. Degradation of vancomycin lead to changes in the composition which were not matched by a similar loss of potency.

Chromatography, High Pressure Liquid↗
PubMed1986

Separation of aromatic heptaene antibiotics by high-performance liquid chromatography.

Thin-layer chromatography and high-performance liquid chromatography have been used to separate and characterize representatives of the aromatic heptaene group of antifungal antibiotics. Most antibiotics were complex mixtures that could be placed in well defined groups. The identity of candicidin and levorin was confirmed in one group. Aureofungin, DJ400 and hamycin shared many components in common in the second group. The proportion of the individual components of lucknomycin and trichomycin was markedly different from each other and from the antibiotics in the other two groups. Lucknomycin stood out as the most homogeneous of the antibiotics examined.

Antifungal Agents↗
PubMed1986

The International Standard for Kanamycin.

The International Reference Preparation of Kanamycin has been replaced by the International Standard for Kanamycin. The potency of the standard is based upon a collaborative study in ten laboratories in ten countries. Each ampoule of the International Standard of Kanamycin is defined as containing the activity of 10345 International Units of Kanamycin.

International Cooperation↗
PubMed1986

Suggested mechanisms for the antimycotic activity of the polyene antibiotics and the N-substituted imidazoles.

The polyene antibiotics and the N-substituted imidazoles (azoles) are two groups of clinically important antifungal drugs. Both are hydrophobic and both interact with the plasma membrane of susceptible fungi but the mode of action of the two groups is not fully resolved. In this paper their biological properties are reviewed in the context of recent work so that common features may be identified and further areas of research indicated.

Amphotericin B↗