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Biomedical subjects

A H Sutor

Publications and source records attributed to A H Sutor.

At least 73 records · Page 4Linked to original sources
PubMed1977

[Intravascular coagulation in anorexia nervosa (author's transl)].

Hypercoagulation and intravascular coagulation developed a nearly 12-year-old girl with a one-year history of typical anorexia. Because of extreme cachexia she had been treated with numerous drugs elsewhere, among them ACTH an infusions of amino-acids. At the end of the second week of hospitalisation acute venous thrombosis of the right leg developed which was treated with heparin. Severe disseminated intravascular coagulopathy and thrombosis of the right leg were diagnosed on admission, the previously administered heparin was neutralised and streptokinase given for 60 hours, heparin was then given for several days, and the cachexia then treated. Both the local and general condition of the patient having been cured, the emotional state has also very much improved during the last year.

Anorexia Nervosa↗
PubMed1977

Alteration of primary hemostasis in hemophiliacs after treatment with lyophilized antihemophilic globulin.

Seven patients with classic hemophilia A had alteration of primary hemostasis after treatment with lyophilized antihemophilic globulin (LAHG). The following test results, which were normal before treatment, became abnormal after treatment: bleeding time, bleeding intensity, and platelet adhesiveness. In two patients, the fibrin-fibrinogen-degradation products increased to more than 40 microgram/ml. In three patients, the bleeding symptoms became worse with LAHG therapy although no inhibitor against Factor VIII was demonstrated. In one of these patients, the bleedings symptoms disappeared when the use of LAHG was discontinued and prednisone was given; at the same time, the altered primary hemostasis returned to normal. In the remaining two patients, prednisone did not have any effect. In these two patients, however, the bleeding stopped, and the bleeding time became normal immediately after freshly prepared blood-group compatible cryoprecipitate was given.

Adolescent↗
PubMed1977

Quantitative bleeding time (hemorrhagometry). A review.

Accurately determining the amount of blood lost during bleeding time tests has been little exploited. Equipment is now available for measuring both the time and volume automatically--a technique called hemorrhagometry. This quantitative procedure has generated a number of interesting and unsuspected observations. Bleeding times lengthen and blood loss is exaggerated as the skin is cooled. This is particularly true of patients who have hemostatic defects, such as hemophilia A; Not only is the hemophiliac different from normal in this regard but, in Sutor's preliminary observations, the asymptomatic carrier of hemophilia A also seems to be distinguishable from the noncarrier on this basis. The test seems potentially useful in evaluating the effect of drugs on platelet function and in assessing mild bleeding diatheses. Variations induced by either warming or cooling the skin may well have clinical applicability.

Blood↗
PubMed1976

[Bleeding times in haemophilia patients treated with lyophilised antihaemophilic globulin (AHG) (author's transl)].

Tests on 16 patients with haemophilia A confirmed earlier studies that bleeding times may be prolonged after treatment with antihaemophilic globulin (AHG). Despite adequate factor VIII substitution by AHG, treatment effect was unsatisfactory in all 16 patients and there were abnormally prolonged bleeding times after several AHG infusions. But determination of bleeding times after single AHG infusion provides no pointer to possible later problems.

Blood Coagulation Tests↗
PubMed1976

[Changes in hemostasis during epilespy treatment using dipropyl acetate. Extended study].

The influence of Dipropyl-Acetate (DPA, Ergenyl) on hemostasis parameters was examined in 12 patients. In 8 cases there was a prolongation of bleeding time, in 2 cases thrombocytopenia, in 6 out of 10 cases the platelet adhesiveness was pathologically reduced. We therefore recommend hemostasis-examinations--with emphasis on the thrombocytic system--in patients taking DPA.

Adolescent↗
PubMed1976

Detection of carriers of hemophilia by hemorrhagometry.

Hemorrhagometry measures bleeding time, bleeding intensity and blood loss from a small standardized skin wound. In patients with hemophilia these values are within the normal range when hemorrhagometry is performed at room temperature (24 degrees C). However, when the wound is cooled to 17 degrees C (cold tolerance test), bleeding time is abnormally long in hemophiliacs. Therefore we applied this test to carriers of hemophilia. The cold tolerance test was performed in 16 proven and 6 probable carriers (criteria according to Nilsson). 14 proven and 4 probable carriers showed abnormal bleeding times of 15 min and more. When hemorrhagometry was performed at room temperature, the carriers could not be distinguished from normal control persons. Of 15 sisters and aunts of hemophiliacs without male offspring (potential carriers) 9 had abnormal cold tolerance test findings, in fair agreement with the probability of 0.5 to be expected theoretically. Thus the hemorrhagometry cold tolerance test seems to be helpful in detecting carriers of hemophilia.

Blood Coagulation Tests↗
PubMed1976

[Von Willebrand-Jürgens syndrome with a variant of factor VIII-associated antigen].

A family is described in which 5 out of 8 children had a marked bleeding disorder. The children showed prolonged bleeding times, abnormal platelet retention upon passage of blood through a glass bead column, the Willebrand factor activity as measured by ristocetin in a washed platelet system was low. Factor VIII/von Willebrand factor protein levels were normal even so the factor VIII-procoagulant activity. Even the parents and one child without any bleeding tendency and normal bleeding times had a reduced Willebrand factor activity. In all these patients evidence of an abnormal protein was observed on crossed antigen-antibody electrophoresis indicating a qualitative defect of the factor VIII/von Willebrand factor protein.

Antigens↗
PubMed1976

[Partial thromboplastin time (PTT) in the pediatric age group. Normal values and changes under different storage conditions (author's transl)].

Normal values for PTT were obtained from 60 infants and children- age 3 days to 14 years- who had unremarkable preoperative coagulation tests and had tolerated surgical procedures without bleeding complications. The 27 infants, who were less than 0.5 years old, had significantly longer PTT-times (mean value 37.65 sec., extreme values 29.6-47.4 sec) than the older children (mean value: 32.72 sec., extreme values: 24.9-40.5 sec). These results, which were obtained with PTT-reagent ROCHE, are considerably shorter than comparable values in the literature. There were no differences in the values from boys or girls. No positive correlation between PTT and bleeding time were found. There were no significant changes of PTT when the whole blood had been stored at room temperature (22-25 degrees C) for 6 to 10 hours before it was tested.

Adolescent↗
PubMed1975

[Bleeding in haemophilia during massive treatment with anti-haemophilic globulin (author's transl)].

After a traffic accident, causing intracranial haemorrhage in a 15-year-old boy with moderately severe haemophilia A, severe bleeding sequelae could not be prevented despite satisfactory substitution with lyophilized antihaemophilic globulin. The bleeding was probably due to a platelet abnormality and not due to an inhibitor. The bleedings were brought under control by freshly prepared cryoprecipitate of the patient's own blood group.

Accidents, Traffic↗
PubMed1975

[Cholestatic jaundice following disseminated intravascular coagulation ("shock-liver") (author's transl)].

Recently we gained increasing evidence of the fact that cholostatic syndromes in young infants are frequently associated with preceeding shock and disseminated intravascular coagulation. This is illustrated by the case of a 4 weeks-old male infant with urosepticemia due to E. coli, which was successfully treated with additional streptokinase. Therefore, in the age-group of early infancy we have to pay attention to the liver as a potential shock-organ similar to the well known shock organs such as kidneys, lungs, skin and brain.

Anti-Bacterial Agents↗