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Biomedical subjects

A H Murley

Publications and source records attributed to A H Murley.

9 recordsLinked to original sources
PubMed1987

Production of cartilage degrading activity by human synovial tissues.

Human synovial tissues have been assayed for the production of cartilage degrading activity (CDA). This activity is thought to be homologous with catabolin/interleukin 1 (IL1) produced by porcine synovium and leucocytes and by human leucocytes. The CDA of 26 rheumatoid (RA) and 41 non-rheumatoid synovia was measured on a dry weight basis. The rheumatoid synovia showed a threefold increase in activity over the non-rheumatoid, but there was no significant overall difference on a deoxyribonucleic acid (DNA) basis. The rheumatoid synovia appeared to consist of two populations; in over half the samples CDA was not related to cellularity, but eight patients had a high CDA and a high cellularity.

Arthritis, Rheumatoid↗
PubMed1987

A clinical method of functional assessment of the shoulder.

Several methods have been devised to estimate shoulder function, none of which is entirely satisfactory. The method described in this article is applicable irrespective of the details of the diagnostic or radiologic abnormalities caused by disease or injury. The method records individual parameters and provides an overall clinical functional assessment. It is accurately reproducible by different observers and is sufficiently sensitive to reveal even small changes in function. The method is easy to perform and requires a minimal amount of time for evaluation of large population groups.

Activities of Daily Living↗
PubMed1977

Intracellular collagen fibers at the pannus-cartilage junction in rheumatoid arthritis.

Sections of the pannus-articular cartilage junction from a patient with rheumatoid arthritis (RA) were prepared for electron microscopy. Cells at this interface contained membrane-bound collagen fibrils, apparently in various stages of digestion. Previous studies have demonstrated intracellular collagen fibrils at sites of very active and rapid collagen resorption. It is suggested that at certain times in certain patients with RA, phagocytosis of cartilage collagen fragments and subsequent intracellular digestion may serve as a supplemental pathway to extracellular collagen degradation.

Arthritis, Rheumatoid↗