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Biomedical subjects

A H Kidd

Publications and source records attributed to A H Kidd.

70 records · Page 4Linked to original sources

Faecal adenoviruses from Glasgow babies. Studies on culture and identity.

Attempts were made to isolate viruses from babies' stools that contained adenoviruses detected by electron microscopy. One hundred and fifty-nine specimens from 71 children were studied and adenoviruses of established serotypes were isolated from 81 stools. Serial stool samples containing adenovirus particles were obtained from 35 children, and prolonged shedding of recognized serotypes was common. Simultaneous and sequential infections by different serotypes were also observed. Thirty-six children shed adenoviruses that could not be isolated using cell cultures normally used to detect adenoviruses, and nine of these children also shed adenoviruses of established serotypes. Passage in Chang conjunctival cell culture allowed characterization of fastidious adenoviruses from 14 children as members of a previously unrecognized serotype.

Adenoviruses, Human↗

In vitro growth of some fastidious adenoviruses from stool specimens.

Sixty-seven stool specimens from 51 children, positive for adenoviruses by electron microscopy and negative for growth in human-embryo kidney cells, were tested for growth in Chang conjunctiva cells. Twenty-eight specimens caused a cytopathic effect over more than one passage in these cultures, and several adenovirus strains grew better at 33 degree C than at 37 degree C. Most of the culture-positive specimens also induced the development of adenovirus antigens in KB cells detectable by a group-specific indirect immunofluorescence test. Twenty-four of the 25 fastidious strains tested were antigenically related and were distinct from the established serotypes commonly isolated from stools.

Adenoviruses, Human↗

Direct identification of enteric adenovirus, a candidate new serotype, associated with infantile gastroenteritis.

Two enzyme-linked immunosorbent assay techniques for detection of adenovirus in stools were developed. The first, which is group-specific, detects the 35 established adenovirus types and, in addition, enteric adenoviruses associated with infantile gastroenteritis. The second technique, which is type-specific, selectively detects enteric adenovirus. The efficiency of these techniques was assayed on nine coded stool specimens from Glasgow children. Eight of nine was classified as adenovirus by the group-speicific enzyme-linked immunosorbent assay. The six enteric adenovirus specimens were antigenically distinct from each of the 35 established adenovirus types but not from each other. They are suggested to represent a new adenovirus serotype which appear to be associated with gastroenteritis without clear-cut respiratory symptoms.

Adenoviruses, Human↗

Depression and senility.

The literature suggests a closer relationship between reversible depression and irreversible senile organicity than generally has been accepted. Accordingly, Zung's Self-Rating Depression Scale was given to 120 men and women, aged 60 or older, of whom 30 of each sex were classified as nonsenile and 30 of each sex were classified as moderately senile by the personnel of senior citizen centers, convalescent hospitals, and nursing homes. The results indicated that moderately senile Ss scored significantly higher on the SRDS than did the nonsenile Ss, that sex differences were not significant, that there were no significant differences between institutionalized and noninstutionalized Ss of either sex in either the nonsenile or the moderately senile groups, and that further refinement of the SRDS and a longitudinal study of personality, experience, and depression would be extremely useful.

Aged↗