Instrumental conditioning of blood pressure elevations in the baboon.
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Animals↗
Biomedical subjects
A H Harris
Publications and source records attributed to A H Harris.
Home care for venous leg ulcers.
More than a quarter of the adult population in the United States is afflicted with lower extremity venous insufficiency, and 1 in 100 have had, or now have, stasis ulcers. Most of these patients will be treated on an outpatient basis, with many of them requiring home health care. The cost to treat venous ulcers alone has been estimated at $750 million to $1 billion a year. Understanding the pathogenesis and treatment of the problem is imperative as home health care nurses move into an era of cost containment and demographic shift toward an increasingly larger elderly population.
Adult↗
Hemodynamic effects of intravenous clonidine in the conscious, normotensive baboon.
Baboons were given eight doses of clonidine hydrochloride (0.04--40 micrograms/kg) via indwelling femoral venous catheters. Systolic and diastolic blood pressures and heart rates were assessed for time course, magnitude of change, time-to-peak change, and duration of effect at each dosage level. The response to clonidine was found to be biphasic--an initial pressor response was followed by a depressor response. During the 2-min intravenous infusion, blood pressures rose while heart rate dropped. Blood pressures subsequently declined while heart rate remained low. Blood pressure decreases and heart rate decreases were both dose and time dependent. The 10-micrograms/kg dose was found to be maximally effective in reducing blood pressure and heart rate for long durations without also producing a substantial pressor episode during infusion.
Aged↗