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Biomedical subjects

A H Cushing

Publications and source records attributed to A H Cushing.

31 records · Page 2Linked to original sources

Cellulitis and necrotizing fasciitis of the abdominal wall in pediatric patients.

Soft tissue infections of the abdominal wall in 14 children were classified as cellulitis (8), necrotizing fasciitis (5), or myositis/myonecrosis (1). These 3 categories were characterized by increasing anatomic depth of infection, clinical severity, and need for more radical surgical treatment. Ten of the 14 children were neonates. The most frequent associations were omphalitis (5), necrotizing enterocolitis (4), and urachal anomalies (3). The severest infections were usually polymicrobial and contained both aerobic and anaerobic bacteria. Important clinical findings in children with necrotizing fasciitis and myositis/myonecrosis were tachycardia, systemic toxicity, severe edema, and, in older children, pain out of proportion to the apparent degree of infection. None of the children had fever or crepitation of the wound. An ominous sign, indicative of the need for immediate, radical debridement was the appearance of a patch of dusky or gangrenous skin. There were two deaths associated with delayed diagnosis of necrotizing fasciitis. One child did not receive radical debridement, and the other received it too late to be of benefit. Although these infections are rare in children, their lethal potential and early diagnostic signs must be recognized.

Abdominal Muscles↗

Cerebral infarction in childhood bacterial meningitis.

Forty-nine children with complicated bacterial meningitis were studied. Thirteen had abnormalities on computed tomography compatible with the diagnosis of brain infarction; one had a brain biopsy with the histological appearance of infarction. Factors exist in childhood bacterial meningitis which are associated with the development of brain infraction.

Biopsy↗

Early decortication for anaerobic empyema in children.

Nine children underwent early decortication for empyema. Three had posttraumatic empyema and six had postpneumonic empyema. The decision for decortication was made 3-5 days after diagnosis of empyema, when it was judged that conventional treatment by antibiotics and intercostal catheter drainage was failing. Such failure was manifested by: loculated effusions (9), persistent fever (8), persistent respiratory distress (3), pulmonary air leak (3), and worsening parenchymal disease (1). The decortication procedure consisted of a standard posterolateral thoracotomy, removal of the fibrinous peel from the visceral and parietal pleurae, debridement or resection of necrotic lung tissue, irrigation of the pleural space, and drainage by intercostal catheters. In the 9 children who underwent this procedure, there were no deaths and a single complication, suppurative thrombophlebitis. Recovery was rapid in 6 out of 9 children, who were discharged within 10 days of operation. The remaining 3 out of 9 children had associated injuries or illnesses that necessitated a longer hospital stay. Bacteriologic studies confirmed anaerobic bacteria in the infected pleural contents of 5 out of 9 children. Bacteroides and anaerobic streptococci were the commonest isolates. Anaerobic infection of the pleural space cannot be cured without aggressive surgical drainage, in addition to antibiotics. Our experience suggests that early decortication is an efficacious procedure for selected children with empyema. The presence of anaerobic bacteria in the empyema may constitute an unequivocal indication for early decortication.

Adolescent↗

Rhizopus osteomyelitis. A case report and review.

Mucormycosis osteomyelitis has previously been described exclusively in association with contiguous infections of rhinocerebral mucormycosis. In a patient with corticosteroid-dependent neutropenia and anemia osteomyelitis of the femur developed caused by the Mucoraceae Rhizopus. Although a primary focus was not identified, we believe this infection was hematogenous in origin. Mitogen stimulation to phytohemagglutinin (PHA) of the patient's lymphocytes revealed depressed cellullar immunity; however, there was specific response to Rhizopus extract. Treatment with systemic amphotericin B prevented further progression of the infection. A review of mucormycosis osteomyelitis is presented.

Adolescent↗

Role of antibody-coated bacteria in the management of urinary tract infections.

The antibody-coated bacteria (ACB) test was used to localize the site of urinary tract infection in a group of pediatric and adult patients. Duration of treatment of ACB-positive (upper tract) and ACB-negative (lower tract) infections was correlated with rates of recurrence during follow-up for six or more months. Two relapses with the same organism occurred after 29 ACB-negative episodes were treated with a short course of antimicrobials (less than or equal to 14 days). Of patients with ACB-positive infections, all four given similar short-duration therapy experienced relapse with the same organism, but none of nine had relapse after long-duration therapy (greater than or equal to 28 days). High cure rates were obtained with less than or equal to 14 days therapy in ACB-negative infections and with greater than or equal to 28 days therapy in ACB-positive cases. The ACB test promises to be useful in predicting the appropriate duration of antibiotic therapy.

Adolescent↗

Role of immunoglobulins in protection against Shigella-induced keratoconjunctives.

Various immunoglobulin preparations were tested for their ability to protect guinea pig eyes from infection by a virulent strain of Shigella flexneri. Secretory immunoglobulin A was effective in delaying or preventing keratoconjunctivitis in eight guinea pigs when it was used to precoat the organism, and was also placed in the eye with the inoculum. Neither immunoglobulin G nor immunoglobulin M gave any protection when used in the same way. Protection by secretory immunoglobulin A appeared to be related to the antishigella antibody content of the immunoglobulin since a low-titered preparation gave less protection than a higher-titered one.

Animals↗

A study of respiratory illnesses in infants and nitrogen dioxide exposure.

Toxicologic and epidemiologic studies have elevated concern that exposure to nitrogen dioxide (NO2) in outdoor and indoor air may increase the frequency and severity of respiratory infections. We have developed and implemented a prospective cohort study to test the hypothesis that exposure to NO2 increases the incidence and severity of respiratory infections during the first 18 mo of life. This study, which was based on extensive pilot research, was designed to address the potential limitations of misclassification, confounding, and inadequate power. Enrollment of 1,315 subjects has been completed. This paper reviews the methods used in the study, characteristics of the enrolled subjects, NO2 concentrations in the homes of study participants, and rates of illness occurrence.

Air Pollution, Indoor↗

Omphalitis: a review.

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Anti-Bacterial Agents↗