Biomedical subjects
Publications and source records attributed to A H Cameron.
The finding of diffuse pulmonary calcification is reported in a 19-month-old female infant who died from an apparent viral pneumonia with systemic involvement due to varicella or herpes simplex infection. The observation is of interest because of the recently described occurrence of lung calcification following chickenpox in adults.
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Two newborn babies with an intact atrial septum are described. In one, the two components of the atrial septum appeared to have become fused after relatively normal initial development; the left side of this heart was hypoplastic. In the other baby the formation of the atrial septum appeared to have been completely anomalous; this heart showed mitral atresia, absence of the left ventricle, and transposition of the great vessels. There was also pulmonary lymphangiectasis in the second case, and it is suggested that this was due to the cardiac malformation obstructing pulmonary venous drainage.
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One hundred forty-one children were diagnosed with Hodgkin's disease between 1957 and 1986 in the West Midlands Health Authority Region (1991 population, 1.1 million children). Eighty-seven were boys and 54 were girls, representing a significant male:female ratio of 1.5:1 (P < 0.01). The average age-standardized incidence rate was 3.6 per million per year with a significant increase in the older age group (> or = 10 years) in the second half of the period (P = 0.02). The mixed cellularity subtype was more common in those younger than 10 years, with nodular sclerosing disease being seen more in those < or = 10 years. Overall survival at 5 years was 76% (65% at 10 years) with a significant difference (P < 0.001) in survival between the first and last decades. There was six second malignancies, five of which could have been treatment related. A positive history of cancer in close relatives was found in 11 patients, and higher social class was found in more older than younger children. These findings support the hypothesis that Hodgkin's disease may have a viral etiology and may be linked with socioeconomic conditions.
Hemangiopericytoma in infants and children is usually benign. A case of recurrent hemangiopericytoma of the mediastinum in a 5-year-old boy is reported. The tumor recurred twice because of incomplete excision in the first instance. Immunohistochemistry of this enigmatic tumor is reviewed and ultrastructural features are described. The importance of total initial excision of the tumor and a prolonged follow-up is highlighted.
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