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Biomedical subjects

A H Brook

Publications and source records attributed to A H Brook.

At least 55 records · Page 3Linked to original sources
PubMed1980

The management of patients with severe hypodontia.

Severe hypodontia is thought to be caused by hereditary and environmental factors. It has a population incidence of 0.3% in the permanent dentition, being much rarer in the deciduous dentition. The management of patients suffering from this condition is described, including the use of conservative, prosthodontic and orthodontic procedures.

Adolescent↗
PubMed1980

Inhalation sedation.

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Anesthesia, Inhalation↗
PubMed1979

Renin, antidiuretic hormone and the kidney in water restriction and rehydration.

1. The effect of restricted water intake followed by voluntary rehydration with water or 10 mM-KCl was studied in four conscious sheep with respect to plasma concentrations of renin, antidiuretic hormone (ADH), protein and electrolytes, and urine flow rate, osmolality and osmolal excretion. 2. Water restriction increased the plasma renin concentration and the plasma ADH concentration. 3. Rehydration with water caused a further rise in plasma renin, but plasma ADH returned to basal levels in less than 2 hr. 4. Rehydration with 10 mM-KCl in order to stabilize plasma K concentration greatly attenuated the post-drinking rise in plasma renin concentration, while plasma ADH levels fell as before. 5. Urine flow rates after rehydration with water and 10 mM-KCl remained low for at least 6 hr in most experiments despite low plasma ADH levels. The effect on urine osmolality ranged from no change to a large drop. 6. The post-drinking antidiuresis was associated with a reduction in solute excretion rate. However, free water clearance usually remained negative. 7. These experiments do not support the existence of a direct nexus between plasma ADH levels and plasma renin concentration.

Animals↗
PubMed1977

On the question of body fluid volume or sodium status influencing renin release.

1. The extent to which renin release is affected by simultaneous changes in body Na and body fluid volume was studied in six sheep. 2. The animals' water intake was restricted for 10-17 days after which they were offered solutions containing varying amounts of NaCl. 3. Plasma renin concentration (PRC) of water restricted sheep was 2-3 times normal. 4. The changes in PRC following drinking were inversely related to the amount of sodium consumed, Na excretion and plasma Na concentration. There was no correlation between the changes of PRC and of plasma volume in so far as the latter is reflected by alterations in plasma protein concentration. 5. We conclude that changes in renin release were related to the animals' handling of NA, and not to alterations in body fluid volume. 6. These findings are compatible with the proposition that renin release was mediated by a macula densa mechanism.

Animals↗