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Biomedical subjects

A Gupta

Publications and source records attributed to A Gupta.

At least 955 records · Page 53Linked to original sources
PubMed1981

Eclipse retinopathy.

Ten patients (13 eyes) suffered from varying degrees of eclipse retinopathy during a solar eclipse on 16 February 1980. There was no correlation between severity of the fundus lesions and the visual acuity. In 8 of the 10 eyes available for follow-up 6/6 or better visual acuity was seen. Early fluorescein studies revealed microleaks in 3 eyes (2 patients) and masking of choroidal fluorescence in 1 eye; however, 1 to 3 weeks later these eyes showed only faint window defects. It is postulated that in mild to moderate lesions there is a transient retinal capillary spasm, producing oedema in anterior retinal layers. Fluorescein angiography in such patients reveals no abnormality or only masking of choroidal fluorescence. However, severe cases develop micropunctures in the tight junctions of the pigment epithelium, leading to microleaks, which are sealed within a short period.

Adolescent↗
PubMed1980

Effect of pyridoxal 5-phosphate on carbidopa and decarboxylation of levodopa.

To study the interaction between enzymes and coenzymes and carbidopa and levodopa, a paired-ion high-pressure liquid chromatographic method was developed to separate carbidopa, dopamine, levodopa, and pyridoxal 5-phosphate. Carbidopa strongly reacted with pyridoxal 5-phosphate, contrary to a previous report. Tyrosine decarboxylase and tyrosine decarboxylase apoenzyme had some activity against levodopa, which could be increased by adding pyridoxal 5-phosphate to the mixture. This activity was inhibited by hydroxylamine hydrochloride.

Apoenzymes↗
PubMed1980

Controlled, semielective, segmental resection for massive colonic hemorrhage.

An aggressive diagnostic work-up to determine the site of bleeding was employed in all 25 patients requiring transfusion of over 1,500 cc of blood for colonic hemorrhage in New Haven in 1977 and 1978. A specific bleeding site that permitted segmental colectomy was found in 23 patients (92 percent). The mortality rate was zero, reflecting the rapid improvement in survival that has occurred in the last decade among patients with massive colonic hemorrhage.

Aged↗