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Biomedical subjects

A Gunji

Publications and source records attributed to A Gunji.

At least 37 records · Page 2Linked to original sources
PubMed2000

[A study on resource based relative values for visiting nursing services].

PURPOSE: The purpose of this study was to investigate the resource based relative values of visiting nursing services, and to analyze the relationships between the relative values and the dimensions of nursing service(time, mental effort and physical effort). METHODS: We interviewed nurses at 20 Home-visit nursing care stations (HVNCS) in the Metropolitan area using the resource based relative value questionnaires. We asked nurses about relative values of "Total Work", and also measured relative weight of 3 dimensions of nursing services. Total Work was defined as comprehensive evaluation of nursing services, with careful consideration of intensity as well as duration. With the dependent variable as Total Work and independent variables as the 3 dimensions, multiple regression analyses were carried out. Furthermore we examined the degree of influence on Total Work by service type and individual respondent. To examine the validity of the results, we timed nursing services and compared the measured time with the answered time. RESULTS: The 107 respondents were all female and their average age was 36.6 years old. They had HVNCS experience of 2.2 years and 95.3% nurses had experience of hospital nursing. "Total Work" and 3 dimension scores were standardized using common logarithms. "Total Work" of every service significantly differed among service types. The 3 dimensions explained 54.6% of Total Work in the multiple regression analysis. Service type explained 3.3% of Total Work. Individual respondent explained 16.0% of Total Work. Answered time and measured time were not significantly different with nursing services. CONCLUSIONS: Although Total Work was somewhat influenced by individual respondent, most of variation was explained by 3 dimensions. Thus, it could be concluded that Total Work is an index of nursing resource input. A further investigation about influence of patients' condition on Total Work is necessary in the future.

Adult↗
PubMed1999

Relatively shorter but intensive isotonic exercise in legs prevented the decrease in maximal aerobic power after 20 days of head down tilt bed rest in man.

As a countermeasures for the decrease in maximal oxygen uptake (VO2max) during prolong simulated weightlessness, it has been suggested that intensive isotonic legs exercise was useful. The reason is possibly that a dynamic and intensive resistance exercise training makes to maintain not only the volume of exercising muscles but also cardiac output. For the reason, it has been studied the effects of 3 different exercise training on VO2max during simulated weightlessness.

Bed Rest↗
PubMed1999

Degraded diet induced thermogenesis induced by 20 days of 6 degrees head down bed rest and effect of resistance training.

In the 21st century, our dream of living in a space will finally become reality. To understand the effects of microgravity on energy expenditure and possible countermeasure against them is important to maintain human health in space. Diet Induced Thermogenesis (DIT) is an increase in energy expenditure after ingestion of a meal, and accounts for 10% of total daily energy expenditure. Recently, the important role of DIT in regulating obesity is suggested. Basal Energy Expenditure (BEE), on the other hand, is the minimum energy expenditure required to keep on living, and accounts for 60-75% of total energy expenditure. Despite the importance of DIT, no information about DIT in microgravity and possible effects of exercise training is available. Therefore, we aimed to investigate, first, the effects of 20-days of 6 degrees head down tilting bed rest (HDBR) on postabsorptive energy expenditure (PEE), DIT, and BEE. Second, the effects of resistance training during HDBR on DIT and BEE.

Adult↗
PubMed1998

Effect of 20 days' bed rest on the reverse cholesterol transport system in healthy young subjects.

OBJECTIVES: To study the effects of 20 days of bed rest on HDL cholesterol, lipoprotein lipase, hepatic triglyceride lipase, cholesterol ester transfer protein and lecithin-cholesterol acyltransferase. DESIGN: A 20-day intervention study. SETTING: Makita general hospital. SUBJECTS: Five male and five female healthy participants, mean age 20.4 years, range 19-24 years. INTERVENTIONS: Twenty days of bed rest. MAIN OUTCOME MEASURES: Lipid, lipoprotein, lipoprotein lipase, hepatic triglyceride lipase, cholesterol ester transfer protein and lecithin-cholesterol acyltransferase. RESULTS: Fasting HDL, HDL2 and HDL3 cholesterol levels decreased from 1.748 to 1.404 mmol L(-1) (P < 0.01), from 0.807 to 0.628 mmol L(-1) (P < 0.01) and from 0.939 to 0.784 mmol L(-1) (P < 0.05), respectively, while VLDL triglyceride levels increased from 0.365 to 0.754 mmol L(-1) (P < 0.05). Plasma post-heparin lipoprotein lipase activity decreased from 0.494 to 0.418 micromol mL(-1) h(-1) (P < 0.01), but plasma post-heparin hepatic triglyceride lipase activity and cholesterol ester transfer protein activity did not change during bed rest. Lecithin-cholesterol acyltransferase activity increased from 72.5 to 84.8 nmol mL(-1) h(-1) (P < 0.001). CONCLUSIONS: Twenty days of bed rest induced a decline in HDL cholesterol levels and an increase in VLDL triglyceride levels. When considering lipoprotein lipase, hepatic triglyceride lipase, cholesterol ester transfer protein and lecithin-cholesterol acyltransferase as factors in the decreased HDL cholesterol, the contribution of lipoprotein lipase is suggested.

Adult↗
PubMed1998

Effects of physiological salt water injection after 20 days of head down tilt bed rest on maximal aerobic power in young males.

There is such a speculation that if the decrease in plasma volume (PV) makes central blood volume (CBV) and stroke volume (SV) reduce during prolonged BR, but if the changes in red cell volume (RCV) is little and a physiological salt water (PSW) volume matched to a body fluid loss is injected, then the increased PV would make CBV increase and the increase would contribute to prevent the decrease of SVmax as well as maximal cardiac output (COmax ). As a result, maximal oxygen uptake (VO2max ) would be come up to the before BR level. In the present study, to investigate the speculation, maximal exercise test immediately following the injection of PSW after prolonged head down tilt bed rest (HDTBR) was performed and compared to the before BR level in young males.

Adolescent↗
PubMed1998

Effect of acute saline infusion on the cardiovascular deconditioning after 20-days head-down tilt bedrest.

Recent study showed that dehydration induced by prolonged exercise significantly impaired orthostatic tolerance with tachycardia and hypotension, and subsequent rehydration restored it. As physiological changes during exposure to actual or simulated microgravity can be viewed as dehydration process, we hypothesized that rehydration after prolonged bedrest may be a promising candidate to countermeasure not only fluid volume loss but also autonomic nervous deconditioning. Therefore, the purpose of present study was to determine the effect of acute rehydration by saline infusion on orthostatic cardiovascular deconditioning after bedrest.

Bed Rest↗
PubMed1998

[Adjuvant chemotherapy with UFT or UFT with OK-432 to patients with gastric and colorectal cancer. Kanto Adjuvant Study Group].

In Japan, long-term oral therapy with tegafur in combination with immunopotentiators is commonly used as adjuvant therapy after curative resection of gastric or colorectal can for gastric and colorectal cancer. When the outcome was analyzed in terms of the relative performance (R.P.) and the individual dose intensity (I.D.I.) of OK-432, gastric cancer patients with a R.P. of 0.5 or higher tended to have a better survival curve. There were no marked differences in lymphocytes subsets, except that the Leu 7 level at 3 months after gastric cancer resection was significantly higher (p < 0.05) in group B than in group A. Thus, no inhibition of the anticancer effect of UFT was noted during long term combination therapy with UFT and an immunopotentiator as postoperative adjuvant therapy for patients who underwent curative resection of gastric or colorectal cancer. The results suggest that UFT combined with long-term OK-432 maintenance therapy may contribute to improve survival rates in gastric cancer patients.

Adjuvants, Immunologic↗
PubMed1997

[The relationship between coronary risk factors and body weight--gender and age difference].

METHODS: The association between Coronary Risk Factors (CRF) and Body Mass Index (BMI, defined as the weight in kilograms divided by the square of the height in meters) was examined in 1,551 Japanese in an urban health promotion sports center. These subjects were 20-84 years of age and free of known cardiovascular disease. Systolic Blood Pressure (SBP), Diastolic Blood Pressure (DBP), High Density Lipoprotein-Cholesterol (HDL-C), Low Density Lipoprotein-Cholesterol (LDL-C), triglyceride (TG), Fasting Blood Sugar (FBS), smoking habits and sports habits were measured for CRF and converted to a score for overall estimation of individual CRF. RESULTS: In analysis, a linear relation was observed between BMI and the sum of CRF scores (CRFI) in both men and women. Men had a higher CRFI and greater increase in CRFI by BMI than women. When examined separately by age strata, women showed a greater increase in CRFI by BMI with the increase in age. In contrast, men over 50 years old showed no increase in CRFI by BMI.

Adult↗
PubMed1997

Effect of a five minutes isokinetic one leg knee extension training on maximal oxygen uptake during 20 days of -6 degrees head-down tilting bed-rest in young male subjects.

Due to prolonged bed rest (BR), maximal oxygen uptake (VO2max) might be decreased by above -8%, even if a moderate supine bicycle exercise (SBE) was performed for 45 to 60 minutes every day during BR. However, the decrement of VO2max was lowered to below -5% by isometric training and using a reverse gradient garment. Further it was rather slightly increased by SBE training with gradually increasing load from 40% to 90% VO2max. The facts suggest the dependency of the decrease of VO2max during BR on exercising muscle mass (MM) and strength. In the present study, therefore, the effects of isokinetic knee extension (Ik-KnE) training on VO2max, exercising MM and muscle contraction strength during BR were investigated. Then, the relationships between changes in VO2max and the muscle mass and strength were considered.

Adult↗
PubMed1997

Short review of human prolonged horizontal bed rest studies in Japan.

As many as 700,000-1,000,000 Japanese are spending a substantial part of their life in bed not being able to resume standing position due to disease and/or accident. Our objectives were urgently derived from that fact. The research project group at Faculty of Medicine, University of Tokyo, in Japan have studied effects of prolonged horizontal bed rest on humans since 1990. Financial supports from the Japanese Ministry of Education (Grant-in aide for scientific research), National Aero Space Development Agency of Japan and Japan Federation for Health Sciences have enabled us to perform five prolonged bed rest experiments for 5 years from 1990 to 1994. Many scientists in Europe, America and Russia have already made a heap of studies on this subject since the latter half of 1940s (eg. 39). However, our studies mainly focused upon the effects of inactivity on human health to determine how to bring a human from inactivity back to an unrestricted active life. This short review is going to summarize our results obtained from 1990 to 1993.

Bed Rest↗
PubMed1997

Effects of 20 days bed rest on muscle morphology.

Using ultrasound, muscle thickness and fascicle angles from aponeurosis were evaluated before, during and after 20 days bed rest (BR). Subjects were healthy adults (4 women and 4 men). Measurements were carried out before and after BR and after 10 weeks of recovery, respectively. Muscle measurements were taken at nine sites in trunk and upper and lower extremities, respectively. For the m. triceps brachii, m. vastus lateralis, and m. gastrocnemius medialis, fascicle angles from the aponeurosis as well as muscle thickness were measured. There was a high statistical significant correlation between muscle thickness and cross-sectional area for quadriceps muscles, suggesting applicability of muscle thickness for evaluation of muscle size. Muscle thickness decreased in muscles of the lower extremity by 2.1-4.4 % after bed rest. In triceps brachii and vastus lateralis muscles, there were no prominent changes in muscle thickness and fascicle angles. It was concluded that muscle morphology deteriorates with changes in muscle architecture by bed rest but the response is small and muscle-specific. It was also suggested that bed rest affects not only muscle mass but muscle tone as well.

Adult↗
PubMed1997

Effects of 20 days of bed rest on physiological cross-sectional area of human thigh and leg muscles evaluated by magnetic resonance imaging.

The present study was to investigate the effects of 20 days of bed rest on morphological characteristics of lower limb skeletal muscles. Ten sedentary volunteers (5 males and 5 females) were participating in this study. Magnetic resonance imaging techniques were used to measure the physiological cross-sectional areas (PCSAs) of the major muscles and muscle groups of the lower limb. Consecutive images were taken from the right thigh and leg of subjects, and muscle volumes (MV), muscle length, and fiber length were calculated. PCSA of each muscle was determined as MV times the cosine of the angle of fiber pennation divided by fiber length. PCSA of knee extensor and flexor muscles were significant reduced during and after bed rest. MV and PCSA of individual muscles in the knee extensors decreased by -5.1 % to -8.0%. In knee flexors, MV and PCSA in biceps femoris (long head), semitendinosus, semimembranosus, and sartorius decreased during and after bed rest. MV and PCSA in medial and lateralis [correction of andateralis] gastrocnemius, and soleus were remarkably reduced by -9.4 to -10.3% after bed rest. The results suggest that there is a great variability of muscle atrophy in the lower limb muscle groups or individual muscle after bed rest and that the plantar flexors primarily affected.

Adult↗
PubMed1997

Changes in force-velocity and power output of upper and lower extremity musculature in young subjects following 20 days bed rest.

Ten healthy sedentary students were exposed to 20 days bed rest (BR) to study the effect of simulated weightlessness on force(F)-velocity(V) characteristics and power(P) output of upper and lower limb movements. F, V and P were measured using a special dynamometer applicable to single joint movements [elbow flexion(EF) and extension(EE), knee flexion(KF) and extension(KE), and hip flexion] or multi-joint movements (squatting). Physiological cross-sectional areas(PCSA) of KF and KE muscles were measured by a magnetic resonance imaging technique. After BR, attenuation in P were observed in lower limb movements (decreased by 19.8-43.6% for squatting, KF and KE), in upper limb movements on the other hand, the decreases in P were not significant (approximately -5% for EF and EE). Decrease in P in lower limb were more pronounced in heavier loaded conditions which were characterized by decreases in both F and V. For KF and KE, decreases in maximal static F (-18.9 to approximately -26.8%) were more pronounced than the decreases observed in the PCSA (approximately -7%), resulting in decreases in specific tension (-12.3 to approximately -22.1%). Neural excitation potentials to generate maximal muscle tension or P might also be influenced by weightlessness.

Adult↗
PubMed1997

Gender differences in effects of 20 days horizontal bed rest on muscle strength in young subjects.

Gender differences in the effect of 20 days bed rest (BR) on muscle strength were evaluated in voluntary 11 male and 7 female students. Maximum Isometric Voluntary Contractions (MVC) of 4 right arm muscles (RAM), 5 right leg muscles (RLM), and 2 body trunk muscles were measured with an isometric dynamometer, respectively. Muscle masses (MM) of right arm and leg and body trunk were determined by dual energy X-ray absorptiometry, respectively. The maximum cross sectional area (CSAmax) of right m. quadriceps femoris was measured by magnetic resonance imaging. Elbow flexion MVC in males and all MVC of RLM except knee flexion in both males and females were decreased (p<0.05), but elbow extension MVC in females was increased (p<0.05), while all of other MVC only tended to decrease. However, the decrements in leg MVC were not correlated to the leg MM, and also the decrement in knee extension was not correlated to the CSAmax of m. quadriceps. The reduction of MVC of antigravity muscles might be caused not only by a decrease in MM but also by other factors. The greater decrements of leg MVC during BR were the higher initial level in males, but the inverse was observed in females. However, this discrepancy between males and females cannot be explained in the present study.

Adolescent↗
PubMed1997

Effects of long term bed rest on stretch reflex responses of elbow flexor muscles.

Stretch reflex responses of m. biceps brachii and m. brachioradialis of ten normal adults were studied before and after 20 days of strict bed rest. A standard torque perturbation (15 Nm, 170 ms) was applied to the forearm to induce reflex electromyographic (EMG) activities of the two muscles investigated. Totally 30 perturbations were applied during submaximal isometric elbow flexion movements at 80 deg flexed joint angle, and ensemble averaged EMG waveforms were calculated by aligning the signal to the onset of perturbations. All subjects showed that both short and long latency stretch reflex FMG activities of m. biceps brachii were reduced immediately after 20 days bed rest, and then recovered gradually to pre-bed rest levels at one- to two-months after bed rest, whereas there was no such variation in the stretch reflex induced in m. brachioradialis. It was demonstrated that the muscle stretch reflex gain might be reduced with long-term inactivity, but the effects on stretch reflex gains were different in the two tested muscles.

Adult↗
PubMed1997

Effects of 20 days horizontal bed rest on maintaining upright standing posture in young persons.

The effects of 20 days horizontal bed rest (BR) on postural reflex were studied by measuring fluctuation of center of gravity in the body during two legs or one leg upright standing in 10 young volunteers. The fluctuation was decided as total moving distance of the center recorded during 60sec standing on a force plate. The stability was measured by the moved area. After BR, the moving distance increased during two legs standing with open eyes (p<0.05), but statistically unchanged with closed eyes. The moving area decreased during right one-leg standing with closed eyes (p<0.05), but unchanged during left one-leg standing. Despite with open eyes the increased distance suggested that postural reflexes to maintain upright position were probably decreased by increased unsuitable feedback informations from the visual receptor deconditioning during BR. The decreased area during right one-leg standing with closed eyes also suggested that the declined standing posture reflex was probably related to more rapidly lowered functions for maintaining standing position in the dominating leg than in the other.

Adult↗
PubMed1997

Effects of 20 days horizontal bed rest on mechanical efficiency during steady state exercise at mild-moderate work intensities in young subjects.

Delta efficiency(DE) at mild-moderate (31%-56% of maximum oxygen uptake) bicycle exercise in the upright sitting and in the supine position was measured in 10 young males and 5 females before and after 20 days bed rest (BR). Total muscle mass in the both legs(TMML) were measured by dual-energy x-ray absorptiometry. After BR, oxygen uptake decreased at all intensities during upright exercise and at 100 W during supine exercise (p<0.05) in the males but cardiac output (acetylene rebreathing) was almost unchanged. As defined as increase in work over the corresponding increase in energy liberation, DE significantly increased by 20.1% during upright exercise and 18.4% during supine exercise in males, but unchanged in females. TMML was decreased in both males and females. The differences in DE between males and females could not be explained in the present study. One possibility might be that the decreased DE was due to a simultaneous decrease in slow twitch muscle fiber content which might be responsible for the decreased TMML induced by BR in the males.

Adult↗