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Biomedical subjects

A Guillard

Publications and source records attributed to A Guillard.

At least 73 records · Page 4Linked to original sources
PubMed1984

[Microcirculatory changes following psychoaffective shocks].

The basis for the study conducted was a clinical observation: the fairly stereotyped microcirculatory disorders occurring during "affective" neuroses. Examinations were performed initially with the capillaroscope alone and then this was combined with plethysmography and Doppler tests in the hands and the fingers (9.2 MHz sound). Fifty-two patients were examined (30 by capillaroscopy alone and 22 with associated plethysmography and Doppler to the hands). A more psychiatrically orientated consultation with 51 of these patients indicated that an affective shock had preceded the onset of the acrosyndrome in 27 cases. The syndromes provoked may be severe and may lead to pseudo-necrotic lesions. High doses of vascular tonics are necessary, the condition being made worse by the tricyclic antidepressants.

Capillaries↗
PubMed1980

[Cerebral venous thrombosis in Behçet's disease (author's transl)].

Two patients with Behcet's disease and angiographically demonstrated cerebral venous thrombosis are described. Dural sinuses were involved in one patient and an internal cerebral vein in the other. Cerebral venous thrombosis was the first manifestation of the disease and occurred in the absence of other signs of "Neuro-Behçet". The outcome was favorable. The unusualness of such localisations, their unknown mechanism, and difficulties in their diagnostic and treatment are emphasized.

Adult↗
PubMed1978

[Long-term prognostic factors in Parkinson's disease (author's transl)].

Acturial methods are used to study the correlation between the initial condition and early therapeutic results, and the present condition of 164 parkinsonian patients treated with L. dopa for 4 to 8 years. There is an ineluctable deterioration in motility. There is a lower risk in patients who are autonomous and only slightly akinetic at the beginning of treatment. Intellectual deterioration is seen in some patients only. The risk factors are: males, the clinical forms of Parkinson's disease in which tremor is not predominant, onset of the disease before 60 years of age, and depression and transitory psychotic disorders during the first year of treatment. This deterioration appears 3 to 5 years after starting dopatherapy, which could be the cause. Life expectancy is still reduced by the disease at the present time. It is longer in patients in whom the disease started with isolated tremors, absence of Babinski's sign, and no loss of autonomy, and those in whom a good initial therapeutic result was obtained.

Age Factors↗
PubMed1976

Fatal systemic carnitine deficiency with lipid storage in skeletal muscle, heart, liver and kidney.

A fatal case of systemic carnitine deficiency is reported. The patient suffered from slowly progressive muscle weakness since early childhood. After the age of 17 years her weakness progressed more rapidly until her death at the age of 20. A pregnancy during the last year of the patient's life was followed by rapid deterioration in her condition. An episode of renal insufficiency occurred at the age of 17 years and hepatomegaly, increased BSP dye retention and intermittent ketoacidosis were present during the last month of her life. Biopsy and autopsy specimens of muscle showed a lipid storage myopathy. Type 1 fibers were selectively severely affected, and many Type 1 fibers were atrophic. Abundant large mitochondria, some also containing abnormal inclusions, were also present in the muscle fibers. At autopsy there was marked accumulation of sudanophilic lipid deposits in all hepatocytes, in the renal tubular epithelial cells, and a patchy increase of lipid material was found in the myocardial fibers. There was marked carnitine deficiency in the patient's liver as well as muscel, while the carnitine palmityltransferase activities in these tissues were abnormally high. The basic metabolic abnormality is assumed to be a defect in carnitine biosynthesis.

Adult↗
PubMed1975

[The deterioration of patients with parkinsonism treated with L-dopa].

A progressive deterioration in clinical state was noted in more than half of a group of 87 patients with parkinsonism treated with dopa for 4 to 6 years. The pattern of this deterioration is often quite particular: frequency of troubles with walking, falls, predominance of akinesia in certain motor functions, inconstant recurrence of tremor or rigidity. Some intellectual deterioration is sometimes seen, more common in those patients who had suffered episodes of mental confusion. 11 patients died. It may, however, be hoped that the average life expectancy will increase.

Aged↗