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Biomedical subjects

A Guha

Publications and source records attributed to A Guha.

168 records · Page 10Linked to original sources
PubMed1965

The effect of vitamin A deficiency and dietary alpha-tocopherol on the stability of rat-liver lysosomes.

1. Vitamin A-deficient rats and pair-fed controls were maintained on either normal or raised amounts of dietary alpha-tocopherol. 2. Their livers were fractionated and ;free' and ;total' lysosomal phosphatase were determined in the various fractions. The rate of release of this enzyme was determined in the mitochondria-lysosome-rich fraction during incubation at pH5 and 37 degrees . 3. The deficient livers showed increased enzymic activity. 4. Prolonged incubation caused more rapid enzyme release from the mitochondria-lysosome-rich fraction of the vitamin A-deficient rats receiving the normal amount of dietary alpha-tocopherol than from the equivalent fraction of their pair-fed controls receiving vitamin A. Raised dietary alpha-tocopherol reversed this phenomenon.

Journal Article↗
PubMedDate not supplied

Platelet-derived growth factor: a general review with emphasis on astrocytomas.

Growth factors acting in a paracrine or autocrine fashion are important in the development of normal cellular structures, and possibly in the development of neoplasia. For example, platelet-derived growth factor (PDGF) has been found in many normal tissues including the CNS, while minor changes in one of its forms (PDGF-B) converts it to the v-sis oncogene, capable of inducing sarcomas and astrocytomas in primates. PDGF is highly expressed in many human astrocytoma-derived cell lines, some of which also possess the PDGF-receptor(s), suggestive of an autocrine loop. Whether this finding is also present in the actual tumor, does it vary with tumor grade, what components of the tumor express PDGF and how does PDGF promote astrocytoma growth are some of the unanswered questions forming the basis of ongoing research efforts. This paper reviews the story of PDGF in a much oversimplified, however, hopefully understandable, fashion and presents the case of why this growth factor is of interest in understanding the biology of astrocytomas.

Animals↗