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Biomedical subjects

A Grosse

Publications and source records attributed to A Grosse.

At least 55 records · Page 3Linked to original sources
PubMed1981

[Variations in serum levels of C-reactive protein in severe head injury patients (author's transl)].

The variations of fibrinogen, alpha-antitrypsin, haptoglobin and C-reactive protein (CRP) were compared in sera from patients with a cranial trauma. All these protein concentrations were increased with CRP variation being the most marked and the most rapid. The prognostic and diagnostic value of CRP determination was studied in a series of 88 patients selected according to their clinical evolution. Four typical serum patterns of CRP were obtained according to the evolution of cranial trauma. The validity of this classification was tested in blind on 324 patients. The authors propose to determine daily serum CRP for four days after a trauma in order to survey its evolution. This biochemical information has to be added to the clinical data.

C-Reactive Protein↗
PubMed1978

[Combined Kuntscher nailing and screw fixation (author's transl)].

The authors describe a technique of Kuntscher intramedullary nailing combined with screws driven through the bone and the nail above and below the fracture site. This technique gives better stability of the fracture and allows extension of intramedullary nailing to severely comminuted fractures, fractures with loss of bone and to proximal or distal fractures. Risks of rotational instability or shortening are diminished. The technique is fully described. With the use of correct ancillary instruments, x-ray exposure is minimal. Biomechanical experiments conducted to determine the best position of the screws for optimal locking of the nail are described. The results obtained in one hundred and sixteen cases are analysed. The technique was also used in the treatment of non-union and in the fixation of osteotomies.

Biomechanical Phenomena↗
PubMedDate not supplied

Osteoprotegerin and receptor activator of nuclear factor-kappaB ligand (RANKL) in the serum of healthy adults.

AIMS: Osteoprotegerin and the receptor activator of the nuclear factor-kappaB ligand (RANKL) are decisive factors for maintaining the balance between bone formation and bone resorption. As new, sensitive ELISAs have been developed recently, reference serum ranges should be established to use these analytes for possible diagnostic purposes. METHODS: Measurements were performed in serum samples of 142 healthy adults (82 women, 60 men) between 20 and 70 years of age (mean age: 46 years) using ELISA kits from Immundiagnostik, Bensheim, Germany. RESULTS: Serum concentrations of osteoprotegerin were age and gender independent and showed a Gaussian distribution, while RANKL concentrations were also age independent but differed between males and females, with a non-Gaussian distribution. For osteoprotegerin a gender-independent upper 97.5 percentile limit of 3.6 pmol/L was calculated while the corresponding limits for RANKL and the ratio of RANKL to osteoprotegerin amounted to 3.29 pmol/L and 2.78 in women and 1.66 pmol/L and 2.18 in men, respectively. CONCLUSIONS: Both osteoprotegerin and RANKL were quantifiable in serum of healthy adults, which means that these compounds can be used as potential diagnostic tools.

Adult↗