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Biomedical subjects

A Grohmann

Publications and source records attributed to A Grohmann.

32 records · Page 2Linked to original sources
PubMed1981

[Characterization of storage-induced release reductions in suppositories (author's transl)].

It is reported of the effect of storage at different temperatures on the release of aminophenazone, codeine phosphate, phenobarbital sodium and trapidil from suppositories, and of the physical parameter of the latter. Depending on the state of division of the drugs in the preparations and on the conditions of storage, drug release from suppositories was more or less affected, which alterations were but incompletely reflected in the physical parameters of the suppositories.

Aminopyrine↗
PubMed1981

[The bioavailability of trapidil from suppositories (author's transl)].

In a study with five healthy persons designed to compare the bioavailability of Trapidil from Rosupol U suppositories with that from Witepsol H 15 suppositories, the availability of Trapidil from the Rosupol U suppositories was inferior in four of the five test subjects. The difference in the amounts of released drug observed in vivo was smaller than that found in vitro.

Adult↗
PubMed1980

[On the action of various factors on the liberation from suppositories (author's transl)].

The authors deal with the effects of five suppository bases on the liberation of aminophenazone, codeine phosphate, phenobarbital natrium and trapidil from suppositories, with regard to the physical properties (melting time, melting range, melting point, viscosity) and the chemical properties (acid number, hydroxyl value, composition of the bases) of the bases and the suppositories as well as of the drugs used (solubility, particle size). The grouping of the causative factors indicated, which must be weighted differently, leads to the characterization of the mechanisms of liberation and to the interpretation of the considerable differences in liberation.

Chemistry, Pharmaceutical↗
PubMed1977

[Growth of non-sporing anaerobes in an oxygen-free blood culture system (author's transl)].

The efficacy of the commercially available Vacutainer blood culture system to support the growth of non-sporing anaerobes was compared with two laboratory-prepared blood culture media (supplemented thioglycollate medium and brain heart infusion). The media were inoculated with 10, 100 and 1000 organisms of the species tested, and the number of colony-forming units was determined at intervals of 8-10 hrs. Analogous experiments were performed with batches of the media to which 10% vol/vol of human blood had been added. From the results obtained with strains of Bacteroides fragilis, Bacteroides thetaiotaomicron, Bacteroides splanchnicus, Sphaerophorus necrophorus, Peptostreptococcus anaerobius and Propionibacterium acnes it became obvious that growth of non-sporing anaerobes was significantly enhanced in the Vacutainer culture tubes, whereas Enterobacteriaceae and Streptococcus spp. grew equally well in all the media tested.

Bacteroidaceae↗