Search PubMed⌕ Search

Biomedical subjects

A Grigorescu

Publications and source records attributed to A Grigorescu.

36 records · Page 2Linked to original sources
PubMedDate not supplied

Variations in LH and FSH serum gonadotropins in the hypophyseal chromophobe adenoma and acromegaly in the woman in relation to age.

Investigation of the gonadotropic function by radioimmunoassay of serum LH and FSH in 62 women with hypophyseal chromophobe adenoma and acromegaly in relation to age and by comparison with 40 normal women revealed low values for LH and FSH during the reporduction period (20--43 years) and increased values in the postmenopausal period (48--84 years) like in physiologic postmenopause. The increase of the gonadotropic function in the hypophyseal tumoral syndrome of the chromophobe adenoma and acromegaly type above the age of 48 from low values compared to the normal to high values like those in physiologic menopause (a gonadotropic turning phenomenon) demonstrate an alteration of the hypothalamic receptors in relation to age and to these diseases.

Acromegaly↗
PubMedDate not supplied

Receptivity disorders in gonadal dysgeneses. i. Klinefelter's syndrome.

Long-term variation (21-30 days) in the gonadotropic hormones level and testosterone was followed up in Klinefelter's syndrome (chromatine positive). Clinically, the authors followed up the development of the androgen-dependent target tissues before and after administration of 400 mg testosterone/month for 6 months. It was also found a fluctuation in the gonadotropic hormones secretion on a 21-30-day trial which differs from that of the normal adult male. We noticed a great variability of the androgen-dependent structures development in one and the same subject or in different subjects, and a low response to the action of big and prolonged doses of testosterone. The authors interpret these findings as a decrease in the sensitivity of the androgen-dependent target structures (hypothalamus and peripheral tissues) induced genetically and fundamenting the concept of the existence of a receptivity pathology.

Adolescent↗
PubMedDate not supplied

Dynamics of the h-LH and h-FSH response after the stimulation test with Gn-RH-LH/FSH in man.

A study was carried out on a number of 17 subjects concerning the dynamics of LH and FSH response after stimulation with Gn-RH-LH/FSH. The results show a stimulation 10 minutes after quick i.v. injection of synthetic RH, with a peak at 20-30 minutes and a persistence of the response of up to 180 min. The variation of the response is proportional with the dose, the response to stimulation being higher for LH than for FSH. The response in the normal adult male is of 82-858% for LH and of 157-250% for FSH. In aged subjects there is an increased response capacity showing that the hypophysis still reacts at an advanced age, with variations depending on the individual characteristics. In Sheehan's syndrome the basal values of FSH and LH are low, with a slight response after stimulation with RH, suggesting the possibility of a partial regeneration of the hypophysis if any intact areas were left after the initial necrotic process.

Adenoma↗