Search PubMed⌕ Search

Biomedical subjects

A Gregor

Publications and source records attributed to A Gregor.

At least 127 records · Page 7Linked to original sources
PubMed1983

Abnormalities in liver function and morphology and impaired aminopyrine metabolism in hereditary hepatic porphyrias.

The aminopyrine breath test and measurement of postprandial serum bile acids were performed in 67 patients with well-documented hereditary hepatic porphyria. Elevated postprandial serum bile acids levels were found in 75% and the aminopyrine breath test was abnormal in 42% of the patients studied. These function tests exhibited a statistically significant correlation with the excretion of porphyrin precursors in patients with acute intermittent porphyria. Furthermore, all 12 patients with acute intermittent porphyria who had a liver biopsy because of abnormalities in the aminopyrine breath test or postprandial serum bile acids measurement, or both, were found to have diffuse, moderately severe, but nonspecific ultrastructural changes of hepatocytes, indicative of significant subcellular damage. While a direct relationship between functional and morphologic abnormalities is speculative, it is possible that the defective heme biosynthesis, perhaps related to the reduced aminopyrine demethylation, could form the basis for the ultrastructural hepatic changes in porphyria. This, in turn, could be the cause of the elevated postprandial serum bile acids levels.

Adult↗
PubMed1982

Computed tomography in the assessment of malignant mesothelioma of the pleura.

Computed tomography (CT) and plain radiography have been performed on 32 patients with malignant mesothelioma of the pleura, in order to assess the extent of disease and suitability for radical treatment. A comparison of the assessments by the two techniques is reported, with confirmation from either thoracotomy or post-mortem findings available in 16 cases. CT was found to be more sensitive than plain radiology in the detection of pleural effusions, although routine lateral decubitus radiographs has not been performed. The two techniques were equally effective in detecting involvement by tumour of the lateral chest wall, mediastinum and lung, with no false positive assessments by either technique, and few false negative assessments. Disease was shown to be extensive and gross at presentation in mesothelioma, so that the greater sensitivity of CT was of no advantage. Diaphragmatic involvement by tumour was accurately assessed by plain radiology but there were frequent false negative assessments by CT, possibly due to difficulty of interpretation of the curved diaphragm on the cross-sectional CT image. In this study CT offered little advantage over conventional radiology.

Adult↗
PubMed1981

Infradiaphragmatic presentation of Hodgkin's disease.

Twenty patients with infradiaphragmatic presentations of Hodgkin's disease were seen at the Royal Marsden Hospital, London, between 1970 and 1977, 13% of the total number of patients with Stage I and II Hodgkin's disease seen in this period (20 out of 153). All the patients were male. Lymphocyte predominance was seen in 35%, nodular sclerosis in 30%, mixed cellularity in 30% and lymphocyte depletion in 5%. There is a lower incidence of nodular sclerosis than seen with supradiaphragmatic presentations. The average age was highest in patients with nodular sclerosing disease. All clinical Stage I patients had negative laparotomies. An approach to staging and treatment similar to that used for clinical supradiaphragmatic disease appears to yield equally good results.

Adolescent↗