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Biomedical subjects

A Greenstein

Publications and source records attributed to A Greenstein.

87 records · Page 5Linked to original sources
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Sexual dysfunction in women partners of men with erectile dysfunction.

We evaluated 113 female partners of men with erectile dysfunction (ED) attending a sexual dysfunction clinic in order to define sexual dysfunction among these women. In all, 51 (45%) women denied having any sexual dysfunction. The other 62 (55%) responded to questions classifying their complaint(s) according to the international classification of female sexual dysfunction (FSD) in the following topics (40/62, 65%, reported having more than one problem): decreased sexual desire (n=35, 56%), sexual aversion (none), arousal (n=23, 37%) and orgasmic disorders (n=39, 63%), dyspareunia (n=19, 31%), vaginismus (n=3, 5%), and noncoital sexual pain (none). Many female partners of men with ED report having some form of sexual disorder, mostly orgasmic problems and decreased sexual desire. Therefore, for optimal outcome of ED treatment, evaluation and treatment of male and FSD should be addressed as one unit within the context of the couple, and be incorporated into one clinic of sexual medicine.

Erectile Dysfunction↗
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Does local hyperthermia affect metastasis of a human prostate carcinoma grown in athymic nude mice?

PRIMARY OBJECTIVE: This study investigated whether local hyperthermia increases metastasis of prostate carcinoma xenografts in athymic nude mice. RESEARCH DESIGN AND METHODS: Human prostate carcinoma cells (1-LN-PC-3-1A) were injected into the animal's thigh. Mice were randomly divided into those treated with local hyperthermia (43 degrees C for 45 min, tumour volume 100 or 200 mm(3)) and untreated controls, and sacrificed when the tumour volume reached 500 mm(3). MAIN OUTCOMES AND RESULTS: Histological evaluation (hematoxylin and eosin staining) of lymph nodes showed metastases in 20/21 hyperthermia-treated and 17/21 control mice. Lymph node involvement, tumour weight at sacrifice, and tumour growth rate were not significantly different between groups. CONCLUSION: Single local hyperthermia treatment had no effect on lymph node metastatic spread in this model.

Animals↗
PubMedDate not supplied

Alleviating constipation in the elderly improves lower urinary tract symptoms.

BACKGROUND: Constipation and lower urinary tract symptoms (LUTS) very frequently occur in the elderly, and several reports have suggested that dysfunction in either one of these systems may affect the other. Most studies correlating rectal and bladder dysfunction, however, have been carried out in children or young women. OBJECTIVE: To examine the effect of alleviating constipation on LUTS in the elderly. METHODS: Fifty-two patients aged 65-89 (mean 72 +/- 13) years with chronic constipation and LUTS participated in this prospective cohort study. Before treatment of constipation was initiated and on their monthly visits, patients completed a questionnaire regarding their constipation pattern, urinary symptoms, sexual function and mood, and underwent urinalysis. Urinary tract anatomy and residual urine were evaluated by abdominal ultrasound at the commencement and completion of the study. Patients were followed up for 4 months. RESULTS: Treatment of constipation increased the number of weekly defecations from 1.5 +/- 0.9 to 4.7 +/- 1.2 (p < 0.001). Patients spent less time on the toilet (25 +/- 2.1 versus 63 +/- 1.9 min, p < 0.0001). Fewer patients reported urgency (16 versus 34, p < 0.001), frequency (25 versus 47, p < 0.001) and burning sensation during urination (6 versus 17, p < 0.05). There was improvement in the scoring of urgency, frequency and burning sensation (from a baseline of 52 to 126, 131 and 95, respectively, p < 0.001). Urinary stream disturbances improved in 32 of the 52 patients (p < 0.001). Residual urine volume decreased from 85 +/- 39.5 to 30 +/- 22.56 ml (p < 0.001). There was also a significant decrease in the number of patients with bacteriurial events (5 versus 17, p < 0.001), and an improvement in sexual activity and mood (p < 0.05). CONCLUSIONS: Our data demonstrated that medical relief of constipation significantly improves LUTS in the elderly which, in turn, improves the patient's mood, sexual activity and quality of life.

Aged↗
PubMedDate not supplied

Maintenance of GI function after bowel surgery and immediate enteral full nutrition. I. Doubling of canine colorectal anastomotic bursting pressure and intestinal wound mature collagen content.

Following either standardized stapled resection of an ileal blind loop terminus (17 beagles) or construction of a colorectal anastomosis (10 beagles), half the subjects immediately were fed an elemental diet (Vivonex HN). Gastrointestinal (GI) motility and absorption were maintained by exclusion of swallowed air. Controls received the same rate of feeding solution containing only the electrolyte components. Four days postoperatively, the fed beagle's colorectal anastomosis had over double the bursting pressure of the control, 303 +/- 46 mm Hg (p less than 0.001). At this time, the mature collagen content of the fed subjects' ileal wound was undiminished from that of normal ileum 2,223 +/- 336 versus 2,250 +/- 577, contrasting with the 45% decrease of this structural component (OHP) in the wounds of the unfed controls, 1,237 +/- 820 microgram/g of tissue (p less than 0.001). Similarly, the wounds of fed but not unfed subjects had a doubling (p less than 0.001) in concentration of collagen precursors and "new" collagen. The "catabolic" and "lag" phases, as noted in unfed experimental animals, appeared to be reflections of the relative starvation that accompanied the intestinal wounding. With maintenance of GI function and immediate full enteral nutrition, "accelerated healing" was noted relative to the previously considered "norm".

Animals↗
PubMedDate not supplied

Subcutaneous ureteral replacement: a canine model.

There are several clinical situations in which extrinsic or intrinsic ureteral diseases necessitate extensive reconstructive surgery. Unfortunately, not all patients are candidates for such surgery (e.g., those with retroperitoneal metastatic disease). Ureteral replacement is indicated in this selected group of patients. A viable option is to establish a ureteral replacement using subcutaneous tubes. Among the problems associated with this method of urine diversion are selecting the proper material for the tubes, the timing of tube replacement, encrustation and occlusion, urine reflux, and renal function. There is an obvious need for an animal model to address these issues. The aim of this study was to establish a reproducible canine model for subcutaneous ureteral replacement, by using a combination of nephrostomy and cystostomy tubes joined together under the skin. The animal study was conducted in 6 dogs. A pigtail nephrostomy and a cystostomy were inserted through a midline abdominal incision and stab wounds in the abdominal wall. A subcutaneous tract was bluntly made toward the nephrostomy incision starting from the cystostomy incision. The nephrostomy was grasped with the clamp and brought through the subcutaneous tunnel to the cystostomy incision. Upon emerging through the cystostomy incision, the tubes were joined and buried under the skin. Intravenous urography at 4-6 weeks postoperatively in 4 dogs showed no deterioration of renal function, but some hydronephrosis was present. Using the technique described in this paper, it is possible to establish a subcutaneous ureteral replacement using nephrostomy and cystostomy tubes in dogs. This model may serve for further research of the various questions associated with subcutaneous ureteral replacement in humans.

Animals↗