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Biomedical subjects

A Greenspan

Publications and source records attributed to A Greenspan.

133 records · Page 8Linked to original sources
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Twelve-month evaluation of rhesus monkey dams and infants after relaxin (hRlx-2) infusion in late pregnancy.

Pregnant rhesus monkeys received daily i.v. infusions of chemically synthesized human relaxin (hRlx-2) (0.1 mg/kg/day N = 6, 2.0 mg/kg/day N = 6, vehicle control N = 7) from the onset of cervical softening to delivery (0 to 14 infusions) to simulate potential therapeutic use of this agent for cervical ripening. Reproductive fitness of dams was evaluated during the next breeding season, and infants were studied through 12 months of age. Birth weight and size, neonatal heart rate and body temperature and neurobehavioral status were not influenced by intrauterine relaxin exposure. Neonatal muscle tone was greater and responsiveness was lower in the hRlx-2 treated infants than in controls. No group differences were seen in infant postnatal growth, maturation or incidence of health problems. Maternal endpoints including uterine involution, resumption of menses, conception rate, and pregnancy outcome were similar across groups. Systemic exposure of rhesus monkeys to relatively high levels of hRlx-2 in late pregnancy did not have apparent long term effects for the measures evaluated under conditions of the experiment. Conclusions concerning adverse effects are limited by the small sample size.

Analysis of Variance↗
PubMedDate not supplied

Myxoid chondrosarcoma of the os calcis: a case report.

This case report of a myxoid chondrosarcoma of the os calcis is presented because of its rarity. The clinical, roentgenographic, and pathological features are discussed, and the difficulty in diagnosis is elaborated.

Aged↗