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Biomedical subjects

A Graham

Publications and source records attributed to A Graham.

262 records · Page 15Linked to original sources
PubMedDate not supplied

Testicular activity in mice selected for increased body weight.

Parameters of testicular function were studied in mice selected for increased body weight and in contemporaneous unselected controls. Spermatogenesis occurred at the same time in the two lines. Body weight, testis weight, mean seminiferous tubular diameter and serum testosterone were increased significantly in the high growth mice. It is suggested that some genetically determined differences in body size are brought about by the differential secretion of testosterone.

Age Factors↗
PubMedDate not supplied

No excess of factor V:Q506 genotype but high prevalence of anticardiolipin antibodies without antiendothelial cell antibodies in retinal vein occlusion in young patients.

Factor V:Q506 (factor V Leiden) is associated with venous thrombosis and has been reported to be a risk factor for retinal vein occlusion (RVO). Anticardiolipin antibodies (ACA), also associated with RVO, are a marker for the prothrombotic condition antiphospholipid syndrome, in which antiendothelial antibodies (AECA) are also frequently present. This study reviewed 45 younger patients 10 GPL units); in 6 of these, the titre was >20 GPL units (population reference range = 0-10 GPL units). No patient had antiendothelial cell reactivity. The low-titre ACA may therefore represent a non-specific response to vascular injury.

Activated Protein C Resistance↗
PubMedDate not supplied

Advocacy: what the future holds.

The author offers a personal view of the importance of the advocacy role for nurses and highlights problems that may arise as a result of changes in the National Health Service.

Cost Control↗
PubMedDate not supplied

Effects of purified Pseudomonas rhamnolipids on bioelectric properties of sheep tracheal epithelium.

The effects of purified rhamnolipids from Pseudomonas aeruginosa on short circuit current in respiratory epithelium have been studied in sheep tracheal epithelium mounted in Ussing chambers under short circuit conditions. In low concentrations (100 microM) mucosal addition of rhamnolipids produces a decrease in short circuit current of 22% and in conductance of 4%. At higher concentrations (> 100 microM), large increases in tissue conductance accompany a greater reduction in short circuit current, suggesting disruption of the intercellular junctions. Serosal addition of rhamnolipids has no effect on ion transport. Pretreatment of the tissues with the sodium channel blocker amiloride (100 microM) or bathing the mucosal surface with sodium-free solution significantly decreased the rhamnolipid-induced fall in short circuit current but did not prevent it completely. Inhibition of chloride transport, sodium-glucose cotransport, and bicarbonate secretion with bumetanide, phloridzin, and acetazolamide, respectively, did not significantly alter the rhamnolipid effect. This suggests that the effect of rhamnolipids on short circuit current is mediated predominantly but not exclusively by an effect on sodium transport. The effects of rhamnolipids on ion transport occur at concentrations within the range occurring in the sputum of patients with cystic fibrosis. The changes in ion transport may explain some of the known effects of rhamnolipid on mucociliary clearance.

Acetazolamide↗
PubMedDate not supplied

Admitting paediatric trauma patients to rehabilitation following acute care: decision making practices in the USA and Australia.

Paediatric patient access to rehabilitation services following trauma has significant long-term implications for clients, their families and the community. The aim of this research was to examine and compare the process by which patients are discharged from acute care and enter rehabilitation in the USA and Australia. The subjects were 31 American and 29 Australian discharge and rehabilitation admission coordinators. Subjects were surveyed about how they currently make trauma to rehabilitation referrals for children. Clinicians in both countries considered the severity of a child's injury and their social situation the most important factors when determining placement for a child. However, there were differences between Australian and US respondents in terms of how important they considered the factor 'medical coverage'. In addition, it was found that clinicians are not consistently using both standardized assessments and formal guidelines to assist them to determine which children should receive rehabilitation following acute care. Benefits of this research include a greater understanding of clinician discharge and admission decision making, and the equity of such decisions. However, further research is required on the influence of payment systems on access to paediatric rehabilitation.

Analysis of Variance↗