Enhanced response of leukemia (L1210) mice to combination chemotherapy with 5-(3,3-dimethyl-1-triazeno) imidazole-4-carboxamide (NSC-45388) and 5-fluorouracil (NSC-19893).
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Animals↗
Biomedical subjects
A Goldin
Publications and source records attributed to A Goldin.
Dihydrofolate reductase activity of leukemia L1210 during development of methotrexate resistance.
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Animals↗
Comparison of the immunosuppressive properties of two related dimethanesulfonates.
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Animals↗
Differential reactivity of mice to alloantigens associated with the D and K end of H-2: preliminary studies with bone marrow and lymphoma grafts.
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Alleles↗
Effect of treatment with two related dimethanesulfonates on the life span and spleen and bone marrow cells of leukemic and nonleukemic mice.
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Amino Alcohols↗
Differential immunogenicity of H-2 alloantigens: a sensitive immuno-pharmacologic test.
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Alleles↗
The chemotherapy of human and animal acute leukemia.
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Animals↗
Effects of priming dose schedules in methotrexate treatment of mouse leukemia L1210.
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Animals↗
Screening of Philippine medicinal plants for anticancer agents using CCNSC Protocols.
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Adenocarcinoma↗
Use of first generation transplants of a slow growing solid tumor for the evaluation of new cancer chemotherapeutic agents.
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Adenocarcinoma↗
Influence of mitotic cycle inhibitors on the antileukemic activity of cytosine arabinoside (NSC-63878) in mice bearing leukemia L1210.
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Animals↗
Evaluation of antileukemic agents in advanced leukemia L1210 in mice. IX.
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Animals↗
Primary antibody response in mice bearing leukemia L1210.
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Animals↗
Dihydrofolate reductase activity and loss of resistance in an antifolate-resistant subline of leukemia L1210 after discontinuation of treatment.
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Animals↗
Immunological alteration of leukemic cells in vivo after treatment with an antitumor drug.
L1210 leukemia was transplanted serially in CDF(1) mice treated with 5-(3,3-dimethyl-1-triazeno)imidazole-4-carboxamide (DIC, NSC 45388). After four different lines (C lines) had been treated for several generations, a marked increase in survival time of untreated mice was observed. In contrast, mice treated with DIC or immunosuppressed with cyclophosphamide succumbed earlier with generalized leukemia. Furthermore, a C line showed unusually high sensitivity to chemotherapeutic treatment with 1,3 bis(2-chloroethyl)-1-nitrosourea. The data suggest that C lines acquired strong antigenicity for CDF(1) and DBA/2 hosts. DIC treatment may have selected highly antigenic variants or induced somatic mutations resulting in the appearance of strong new transplantation antigen(s).
Animals↗
Combination chemotherapy of mouse leukemia L 1210 with a neuroleptic and antimetabolites.
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Animals↗
Reduction of antileukemic and immunosuppressive activities of 5-azacytidine in mice by concurrent treatment with uridine.
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Animals↗
The use of leucovorin orally in normal and leukemic L1210 mice to prevent the toxicity and gastrointestinal lesions caused by high doses of methotrexate.
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Administration, Oral↗