Paradoxical (right-to-left) shunting across an iatrogenic atrial septal defect during Valsalva's maneuver: a transesophageal Doppler echocardiographic study.
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Blood Flow Velocity↗
Biomedical subjects
A Goldfarb
Publications and source records attributed to A Goldfarb.
Echocardiographic diagnosis of atrioventricular septal perforation caused by an aortic valve vegetation.
A case of aortic valve endocarditis is presented in which a vegetation eroded through the atrioventricular septum and extended into the right atrium. This was diagnosed by echocardiography and confirmed at surgery.
Aged↗
A patient with right and left atrial membranes: the role of transesophageal echocardiography and magnetic resonance imaging in diagnosis.
A patient who had right and left atrial membranes was examined. The diagnosis and the hemodynamic significance of both membranes were detailed by transesophageal echocardiography and were confirmed by magnetic resonance imaging. Transesophageal imaging was found to be superior to routine echocardiography in visualization of these atrial structures.
Adult↗
Monotherapy with rituximab induces rapid remission of recurrent cold agglutinin-mediated hemolytic anemia in a patient with indolent lympho-plasmacytic lymphoma.
Cold agglutinin mediated immune hemolytic anemia secondary to lymphoproliferative disease (LPD), is primarily treated with measures directed to eliminate the malignant clone and as such, chemotherapy is usually given. The recent availability of monoclonal antibodies, has made it feasible to obtain both a clinical and molecular remission, as well as a remission on the functional level, such as elimination of secondary autoimmune phenomena. Recently we have administered a course of monotherapy with rituximab (4 weekly injections, x 375 mg/m2) to a patient with refractory and transfusion dependent cold agglutinin mediated hemolytic anemia secondary to indolent B-cell lymphoma. She achieved complete remission with a significant improvement in hemolysis and also became transfusion independent with a current follow-up of over one year. In individual cases, Rituximab has the potential of achieving not only a complete clinical remission (CR) but also a molecular CR, as well as a "functional" CR, by eliminating the clinical manifestations of autoimmunity; in this case, cold agglutinin mediated hemolytic anemia, secondary to NHL. Good results in autoimmunity secondary to lymphoma raises the possibility of future potential benefit of this agent in other primary autoimmune disorders.
Aged↗
Fracture patterns in thalassemia.
Of 61 patients with homozygous beta-thalassemia, 30 had fractures; the majority were single fractures. In three thalassemic families, multiple fractures were observed. Although fractures occurred mostly during the growth period, no epiphyseal fractures were found among the patients in the present study. Roentgenograms showed either horizontal or oblique fractures, frequently with compression, or linear fractures without displacement. No delay in fracture healing or residual gross bone deformities were noted, with the exception of fractures of the femoral neck. On the basis of clinical and scintigraphic examinations, four additional adolescent patients, excluded from this study, were suspected of having microfractures around their ankles and knees. In the future, with improvements in diagnostic methods, microfractures may be found often and recognized as a common source of acute pain about the knees and ankles of thalassemic patients.
Adolescent↗
[Heterogeneity of bilateral adrenal hemorrhage in newborn infants].
Bilateral adrenal haemorrhage was diagnosed in 3 newborns. Clinical, biological and hormonal features were different in each case: abdominal mass in the first case; hyponatremic dehydration for the two others. This hyponatremic dehydration was related to temporary acute adrenal insufficiency for one newborn while association with medullary necrosis did not allow to assert hypoadrenalism for the other. These three cases emphasize: 1) variability of presentation at onset; 2) heterogeneousness of salt loose syndrome; 3) interest of systematic renal and adrenal exploration in adrenal haemorrhage.
Adrenal Gland Diseases↗