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Biomedical subjects

A Goldberg

Publications and source records attributed to A Goldberg.

At least 271 records · Page 15Linked to original sources
PubMed1974

Drinking water as a source of lead pollution.

Frank lead poisoning was found in some inhabitants of houses in the Scottish Highlands, exposed to soft water and lead-lined drinking water tanks. Further investigations were carried out on the clinical and metabolic effects of lead acquired by drinking soft domestic water from lead plumbing systems in 23 Glasgow households. The lead content of water from cold taps was up to 18 times the upper acceptable limit and was proportional to the amount of lead in the plumbing system. The blood lead of 71 inhabitants of these houses showed a significant positive correlation with water lead content. Delta aminolaevulic acid dehydrase activity, an extremely sensitive indicator of lead exposure, showed a significant negative correlation with water-lead content. Atmospheric lead was within acceptable limits in all but one house and no significant correlation could be found with biochemical measurements. A small number of clinical abnormalities were found but could not be directly attributed to lead toxicity. The results of the study underline the possible danger to health of lead plumbing systems in soft-water regions.

Humans↗
PubMed1973

Acute intermittent porphyria: response of tachycardia and hypertension to propranolol.

In four young adult patients with acute attacks of acute intermittent porphyria tachycardia and hypertension were prominent features of the illness. Urinary catecholamine excretion was increased in both patients in whom it was measured. The effect of the beta-adrenergic blocking drug propranolol was assessed in each case. The dose varied from 40 to 240 mg daily. A response in the form of a reduction in heart rate and blood pressure was noted in each case, and in one case a marked alleviation of abdominal pain followed administration of the drug.Propranolol, when given in high dosage to rats, did not induce an increase in hepatic delta-aminolaevulic acid synthetase, an enzyme which is raised in human and drug-induced animal porphyria. The use of propranolol is therefore unlikely to aggravate or precipitate an attack of acute intermittent porphyria.

5-Aminolevulinate Synthetase↗
PubMed1972

Lead poisoning.

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Child↗