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Biomedical subjects

A Godfrey

Publications and source records attributed to A Godfrey.

13 recordsLinked to original sources
PubMed2006

Comparison of the performance of the activPAL Professional physical activity logger to a discrete accelerometer-based activity monitor.

The aim of this study was to assess the accuracy of the 'activPAL Professional' physical activity logger by comparing its output to that of a proven discrete accelerometer-based activity monitor during extended measurements on healthy subjects while performing activities of daily living (ADL). Ten healthy adults, with unrestricted mobility, wore both the activPAL and the discrete dual accelerometer (Analog Devices ADXL202)-based activity monitor that recorded in synchronization with each other. The accelerometer derived data were then compared to that generated by the activPAL and a complete statistical and error analysis was performed using a Matlab program. This program determined trunk and thigh inclination angles to distinguish between sitting/lying, standing and stepping for the discrete accelerometer device and amount of time spent on each activity. Analysis was performed on a second-by-second basis and then categorized at 15s intervals in direct comparison with the activPAL generated data. Of the total time monitored (approximately 60 h) the detection accuracies for static and dynamic activities were approximately 98%. In a population of healthy adults, the data obtained from the activPAL Professional physical activity logger for both static and dynamic activities showed a close match to a proven discrete accelerometer data with an offset of approximately 2% between the two systems.

Acceleration↗
PubMed2005

Classification tool for the systematic histological assessment of hepatocellular carcinoma, macroregenerative nodules, and dysplastic nodules in cirrhotic liver.

AIM: To design a classification tool for the histological assessment of hepatocellular carcinoma (HCC), dysplastic nodules (DN), and macroregenerative nodules (MRN) in cirrhotic liver. METHODS: Two hundred and twelve hepatocellular nodules (106 HCC; 74 MRN; 32 DN) were assessed systematically, quantitatively, and semiquantitatively as appropriate for 10 histological features that have been described as helpful in distinguishing small HCC, DN, and MRN in cirrhotic livers. The data were analyzed by multiple correspondence analysis (MCA). RESULTS: MCA distributed HCC, DN, and MRN as defined by traditional histological evaluation as well as the individual histological variables, in a "malignancy scale". Based on the MCA data representation, we created a classification tool, which categorizes an individual nodular lesion as MRN, DN, or HCC based on the balance of all histological features (i.e., vascular invasion, capsular invasion, tumor necrosis, tumor heterogeneity, reticulin loss, capillarization of sinusoids, trabecular thickness, nuclear atypia, and mitotic activity). The classification tool classified most (83%) of a validation set of 47 nodules in the same way as the routine histological assessment. No discrepancies were present for DN and MRN between the routine histological assignment and the classification tool. Of 25 HCC assigned by routine assessment in the validation set, 8 were assigned to the DN category by the classification tool. CONCLUSION: We have designed a classification tool for the histological assessment of HCC and its putative precursors in cirrhotic liver. Application of this tool systematically records histological features of diagnostic importance in the evaluation of small HCC.

Carcinoma, Hepatocellular↗
PubMed2003

Determining dislocation cell sizes for high-strain deformation microstructures using the EBSP technique.

The effect of several data collection and processing choices has been examined for high-resolution electron back-scatter pattern (EBSP) investigation of a highly deformed sample. The results were compared with a transmission electron microscope (TEM) investigation of the same sample. The estimated dislocation cell size was examined as a function of data cleaning strategy, line intercept vs. reconstruction method, critical misorientation angle definition and step-size. The best agreement with the TEM results was obtained using a modified relative reconstruction algorithm on fine step-size maps allowing some of the noise in the data to be overcome. Step sizes of up to one-quarter the average cell size yielded similar values for the estimated average cell size. As a result of the mixture of both high- and low-angle boundaries, single diffraction condition TEM images may give larger cell size estimates than the EBSP data. Orientation noise in the EBSP data, however, still limits the extent to which quantitative information can be extracted.

Journal Article↗
PubMed2000

Unsupervised approval criteria for automated EBSP investigation of deformed metals.

Unsupervised approval criteria have been investigated for orientations gathered from cold deformed samples (medium to high strain range) using the electron backscattering pattern technique. For such samples, the dislocation cell-size is on the order of the available step-size and pattern quality is generally low. Approval criteria for assessing the validity of measured orientations under these conditions were determined using, as a calibration, channel die cold deformed single crystals of stable orientations. In all cases, approval criteria based on an indexing confidence measure are found to be preferable. Different criteria are suggested, depending on whether the orientation data are subsequently to be used for texture analysis, or for a misorientation angle-based analysis. The latter is illustrated by an investigation of the number of deformation generated high angle boundaries introduced during a 90% cold reduction of a polycrystalline sample.

Journal Article↗
PubMed2000

Developing community health nursing skills collaboration in a culturally diverse population.

The graduate curriculum in Community Health Nursing at the University of South Alabama was revised to prepare nurses to function as a community health specialist. The revised curriculum model includes two semesters that focus on a specific population or high risk group of patients or clients. Emphasis is placed on the skills that community health nurses must have in order to assess communities, identify community needs, plan and implement interventions at the population aggregate or community level. During the first semester, or the practicum course, a community needs assessment is performed. In the internship course, the planned intervention is implemented and evaluated. The purpose of the paper is to describe the process of identifying and accessing a Cambodian population aggregate in a rural setting. The collaboration among faculty, student, preceptor, official agency, as well as lay leaders in the Cambodian community is described.

Alabama↗
PubMed1990

Cosmetic surgery for Cornelia de Lange syndrome.

A case of Cornelia de Lange syndrome is presented in which modern plastic surgery was used to reduce excessive facial hair. Hairless forehead skin was enlarged using a tissue expander and earlobes were resurfaced.

Adolescent↗
PubMed1983

The "antenna" procedure for the "hook-nail" deformity.

The hook-nail deformity is a relatively common problem after fingertip amputations. It is usually ignored but can be quite disabling. This deformity can be corrected by a carefully planned operation. Most of the curved nail plate is removed, the pulp is reflected from the distal phalanx out to a normal contour, and then the full thickness of the nail bed is elevated off the distal phalanx and splinted by multiple small Kirschner pins in a straight position. The defect created is covered with a cross finger flap.

Adolescent↗
PubMed1966

Polyribosomes in rat-liver preparations.

1. The distribution of rat-liver polyribosomes in sucrose density gradients has been investigated with regard to the effects of the preparative procedures and the physiological and pathological condition of the animal. 2. By using carefully defined conditions, three principal polyribosomal fractions have been isolated with S(20,w) values of 340, 275 and 225s in addition to the dimerized 120s and single 80s ribosomes. 3. The polyribosomes were very sensitive to treatment with ribonuclease and to mechanical stresses. 4. Incubation of dispersed hepatic cells and also cell-free preparations with puromycin in the presence of ATP and phosphoenolpyruvate caused rapid partial degradation of the polyribosomes. Treatment of the dispersed cells with actinomycin D also degraded the polyribosomes. 5. The liver polyribosomes of rats not raised under pathogen-free conditions and possibly of rats with an arthritic syndrome may be more fragile than those of healthy pathogen-free animals. 6. Treatment of pathogen-free rats with drugs stimulating liver anabolism profoundly affected the distribution of polyribosomes in sucrose density gradients.

Animals↗