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Biomedical subjects

A Godál

Publications and source records attributed to A Godál.

12 recordsLinked to original sources
PubMed1993

In vitro antiproliferative effect of interferon alpha in solid tumors: a potential predictive test.

An in vitro test for the antiproliferative effect of human leukocyte interferon (IFN-alpha) was performed in primary cultures of tumor cells obtained from 32 patients with either malignant melanoma (13), renal carcinoma (4) or bladder carcinoma (15). Our results demonstrated activity of IFN in all three groups of solid tumors. However, appreciable differences in sensitivity to antiproliferative effect of IFN between individual tumors of the same type were found. The potential of this antiproliferative test for prediction of treatment response in IFN-therapy is discussed.

Adult↗
PubMed1979

Carcinogenicity and polarographic behaviour of dibenzo[a,h]pyrene, 4,11-diazadibenzo[a,h]pyrene and 7,14-diazadibenzo[a,h]pyrene.

In a simultaneous test of carcinogenicity the writers have studied the activities of dibenzo[a,h]pyrene (I), 4,11-diazadibenzo[a,h]pyrene (II) and 7,14-diazadibenzo[a,h]pyrene (III). These compounds were dispersed in paraffin disks and subcutaneously implanted in rats. Each experimental group consisted of 30 animals. The number of sarcomas induced by (I) and (II) was 23 and 16 respectively. The compound (III) has proved wholly inactive. Tumorigenicity of (I) and (II) was found to be proportional to their electron donation and inversely proportional to their electron acceptance in the performed polarographic test. Inactivity of (III) is being discussed from the aspect of molecular geometry.

Animals↗
PubMed1978

Carcinogenicity and polarographic behavior of dibenz[a,h]anthracene, dibenz[a,h]acridine and dibenz[a,h]phenazine.

In a simultaneous test of carcinogenicity the authors have studied the activities of dibenz-[a,h]anthracene, dibenz[a,h]acridine and dibenz-[a,h]phenazine. These compounds were dispersed in paraffin disks and subcutaneously implanted in rats. Each experimental group consisted of 30 animals. The number of sarcomas induced by the above-mentioned compounds was 20, 5 and 3 respectively. Tumorigenicity of the aza analogues of dibenz[a,h]anthracene was proportional to their electron donation and inversely proportional to their electron acceptance in the performed polarographic test. The authors discuss the possibilities of using polarography as a screening test for the exclusion of carcinogenic polycyclic compounds.

Acridines↗
PubMed1975

Long-term results in rectum carcinoma. Patients followed up during the period 1959-1968.

During the period 1959 to 1968, a total of 158 patients with carcinoma of the rectum were treated at the surgical department of the Oncological Institute in Bratislava. All these patients were retro spectively classified according to the TNM system into four clinical stages as follows: Stage I -- 26 (16.46%). Stage II -- 12 (7.59%), Stage III -- 61 (36.61%) and Stage IV -- 59 (53.39%) of the patient. Surgical treatment was supplemented with irradiation in 85 (53.73%) of the patients with chemotherapy in 15 (9.49%). All the findings were verified histologically. Favorable results as regards the 5-year survival rate in accordance with literature data were achieved in the early stages of the affection, while in advanced stages this survival rate was rather low, the majority of the patients died in the first and second year following initiation of treatment. The authors express the view that in future, oncologists will have to devote more attention to an early diagnosis and treatment of precanceroses, and this not solely in patients with a carcinoma of the rectum, but also in its other localizations.

Adult↗