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Biomedical subjects

A Glass

Publications and source records attributed to A Glass.

At least 55 records · Page 3Linked to original sources
PubMed1980

Capsular arthroplasty of the hip for congenital dislocation.

During a 20-year period, capsular arthroplasty was performed on 32 congenitally dislocated hips (28 patients). The Colonna procedure was used, except that prereduction traction was omitted. Capsular arthroplasty was a primary surgical procedure for 12 patients (15 hips) in whom a late diagnosis of CDH was made (mean age at diagnosis, 3.9 years). The same operation was performed as a secondary, or salvage, procedure in a group of 16 patients (17 hips) who had undergone one or more previous operations that failed to secure reduction. The results of treatment in the two groups did not differ significantly. Long-term stability was achieved in 27/32 hips (84%). Excellent or good results were obtained in 17/32 hips (53%). Fair or poor results were obtained in 15/32 hips (47%). In 10/32 hips, there was marked stiffness and in 5/32 hips, redislocation occurred.

Arthroplasty↗
PubMed1975

L-Phenylalanine mustard (L-PAM) in the management of primary breast cancer. A report of early findings.

Prolonged l-phenylalanine mustard (L-PAM) administration as an adjuvant to mastectomy in the management of patients with primary breast cancer and pathologically positive axillary nodes was evaluated by a prospective, randomized, clinical trial. Treatment failures occurred in 22 per cent of 108 patients receiving placebo and 9.7 per cent of 103 women given L-PAM (p = 0.01). A statistically significant difference (p = 0.02) existed in favor of L-PAM relative to disease-free interval. In premenopausal women, the difference with respect to disease-free interval of treated and control groups was highly significant (p = 0.008). A treatment failure occurred in 30 per cent of premenopausal patients receiving placebo and 3 per cent of those treated with L-PAM (p = 0.008). Whereas a similar trend was observed in postmenopausal patients, the difference is not statistically significant. Thus, L-PAM has been demonstrated to be effective in the treatment of women with primary breast cancer, particularly those who are premenopausal. Results were achieved with minimal undesirable side effects.

Bone Marrow↗
PubMed1975

The localization of equivalent dipoles of EEG sources by the application of electrical field theory.

A technique is described for finding the position, magnitude and orientation of the equivalent electrical dipole of EEG activity given the pattern of potential differences recorded at the scalp. The technique is based on an iterative computer program implementing equations describing the electrical field of a dipole in a spherical conductor. The computer program was tested in vitro against data obtained from an inert spherical conductor (a bowl containing physiological saline, fitted with recording electrodes and a movable dipole) and an anisotropic conductor (a similarly equipped human skill including a simulated scalp). In both practical models, the computer program accurately located the dipole, the mean differences between observed and computed loci being of the order of 1 cm at widely different locations. This accuracy was maintained in the anisotropic model even though potentials transmitted through the skill were attenuated by 80%. In vivo, the program successfully located the equivalent generator of blink artefacts within the remaining eye of a one-eyed subject and, in a normal subject, localized the dipole of corresponding potentials to a midline inter-ocular position. In further investigation of normal subjects, the distribution of amplitudes at latencies within Wave V of the visual evoked response confirmed the loci of equivalent generators within posterior cerebral regions. The technique was also applied to the alpha rhythm indicating a posterior locus compatible with the view that alpha rhythm is generated chiefly by posterior cerebral cortex. Factors affecting the accuracy of the technique and the limitations of one-dipole models are discussed.

Action Potentials↗
PubMed1975

The regulation of potassium absorption in barley roots.

The dynamics of changes in K(+) influx across the plasmalemma and of internal K(+) concentrations [K(+)](1) of intact barley (Hordeum vulgare) roots were examined as the roots were converted from ;high-salt' to ;low-salt' roots. Following the transfer of plants grown in 0.5 mm CaSO(4) solutions plus various concentrations of KCl to 0.5 mm CaSO(4) solutions, influx rates increased and internal K(+) concentrations declined as a function of time and the initial K(+) status of the tissue. The relationship between plasmalemma influx and [K(+)](1) was examined over a wide range of [K(+)](1) values by growing intact plants in various concentrations of KCl. Plasmalemma influx was inversely correlated with the square of [K(+)](1). A model for the regulation of plasmalemma influx by [K(+)](1) is considered.

Journal Article↗