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Biomedical subjects

A Giorgi

Publications and source records attributed to A Giorgi.

At least 37 records · Page 2Linked to original sources
PubMed1997

[Nonsteroidal anti-inflammatory agents: their topical use in the treatment of xerophthalmia secondary to Sjögren's syndrome].

The authors, in a case-control study, analyzed the topical application of nonsteroidal anti-inflammatory drug (flurbiprofene drops) in patients affected by keratoconjunctivitis sicca in Sjögren's syndrome. The variation of break-up-time values, and xerophthalmia grade were analyzed. A mild increase of mean values of break-up-time (two seconds in the treated group), and a mild decrease of xerophthalmia grade were found.

Administration, Topical↗
PubMed1996

Weight and plyometric training: effects on eccentric and concentric force production.

The study was performed in an effort to gain greater insights into the adaptations invoked by plyometric and weight training. Forty-one previously trained males were randomly allocated in either a control, plyometric, or weight-training group. The experimental groups trained for 8 weeks, performing either heavy lifts or dynamic plyometric exercises. The following test items were performed prior to and at the completion of the training period: (a) vertical jump, (b) a series of isoinertial concentric and eccentric tests, (c) push-up tests, and (d) maximal bench press and squat lifts. Plyometric training significantly enhanced the rate of eccentric lower body force production. The weight-training group primarily enhanced concentric function. These results were attributed to the specific stresses imposed by the differing forms of training and are discussed with reference to methods of enhancing training induced adaptations and the types of movements such training would tend to facilitate.

Adaptation, Physiological↗
PubMed1990

Clinical effects of cyclosporin in dermatomyositis.

Auto-immune mechanisms, mostly cell mediated, have been described as the basic abnormality in polymyositis and dermatomyositis. We report here the case of a patient affected with dermatopolymyositis, resistant to therapy, who was treated with corticosteroids and cyclosporin. She presented with an infiltrative, erythematous rash on the neck, eyelids and cheeks and weakness of the proximal limb and cervical muscles. The dramatic and persistent response to cyclosporin obtained in this case represents a clear demonstration of the action of this drug in cases of dermatomyositis.

Azathioprine↗
PubMed1987

Identification of vaginal lactobacilli from asymptomatic women.

In the present work, carried out by means of phenotypic and genotypic tests, it has been demonstrated that none of the vaginal lactobacilli isolated from asymptomatic women were genetically close to L. acidophilus ATCC 4356. Strains of homofermentative lactobacilli were identified as Lactobacillus gasseri, L. jensenii and L. crispatus, while in the heterofermentative only one strain was classified as L. fermentum. Moreover a genetically homologous group of heterofermentative lactobacilli, that could represent a new species, were evidenced.

DNA, Bacterial↗
PubMed1986

[Antibacterial and antifungal activity of isoflurane and common anesthetic gases].

An in vitro analysis was conducted to investigate the hypothetical antibacterial and antimycotic activity of the common anesthetic gases (halothane, enflurane, isoflurane, methoxyflurane) in view of the clinical absence of bronchopulmonary pathology after inhalation narcosis despite the many risk factors involved. For this purpose scalar dilutions of the four gases were prepared on cultures of Klebsiella pneumoniae and Candida albicans and the antibacterial action of the gases was tested in vitro. Even with the weaker concentrations used, halothane and methoxyflurane totally inhibited both microorganisms. Enflurane had less effect on Klebsiella p. and almost none on Candida. Isoflurane, a new halogen ether anesthetic was found to have an excellent inhibitory effect. In conclusion it is hypothesised that the anesthetic gases considered might have an in vivo antibacterial activity considering the experimental results obtained in vitro.

Anesthetics↗
PubMed1983

Circadian rhythm of gastric inhibitory polypeptide (GIP) in man.

The diurnal variations of serum gastric inhibitory polypeptide (GIP), serum insulin, plasma glucagon, plasma glucose and serum triglycerides were studied for 24 hr in 6 healthy young men, consuming three meals and performing their usual physical activities. Serum GIP levels peaked after each meal and stayed significantly elevated from the peak after lunch till late night. Glucose and insulin showed early and short-lasting postprandial peaks, declining thereafter to basal values within a short time. Plasma glucagon was inhibited by the meal ingestion and fluctuated around the basal levels in the interdigestive periods. On the other hand, serum triglycerides tended to parallel GIP changes for most of the day, being significantly elevated starting from lunch consumption to late night. The present results suggest that GIP may have effects other than the insulinogenic one, being probably involved in the control of lipid metabolism.

Adult↗
PubMedDate not supplied

Cardiopulmonary bypass in ewe's fetus: advances and setbacks in our learning curve.

Fetal cardiac surgery represents a surgical challenge and several centers are attempting to establish a suitable methodology in animals. We present our experience with extra-corporeal bypass procedures in preterm and term sheep fetuses. Twenty-two fetuses (103-139 days gestation, mean 115 days gestation) underwent a 1-hour period of right heart-to-pulmonary artery extracorporeal circulation followed by 1 hour of observation. Animals were divided into group 1 and group 2, according to gestational age (above and below 0.85). Three pumps were used: centrifugal without (group 1) reservoir, centrifugal with (group 2) reservoir, and roller with reservoir (group 2). Experiments were completed in 75% of fetuses in group 1 and in 37% of fetuses in group 2. Bleeding was the main cause of failure, especially for group 2. A slow deterioration of blood gas status was noted in group 1, while this trend could be partially reversed in group 2 with corrective measures. Complete heart bypass could not be achieved in either group, and residual fluctuations in arterial pressure were observed. During bypass, body temperature decreased more in group 2 than in group 1. We conclude that cardiac bypass is feasible over a short period in near-term fetuses. A successful outcome may also be obtained in younger fetuses, but better measures need to be implemented for the prevention of surgical bleeding.

Animals↗