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Biomedical subjects

A Gimeno

Publications and source records attributed to A Gimeno.

At least 73 records · Page 4Linked to original sources
PubMed1973

Mitochondrial functions in five cases of human neuromuscular disorders.

We determined the respiration, respiratory control, and Pi:O ratios with different substrates in mitochondria isolated from five cases of human neuromuscular disorders (two cases of central core disease, two cases of neuropathy of Dejerine-Sottas, and one case of Kugelberg-Welander's disease) and compared them with normal human muscle. In all the myopathies studied, a severe derangement of the respiratory control with variable derangement of oxidative phosphorylation was found. This supports the idea that a group of neuromyopathies shares the same biochemical lesion as the so-called mitochondrial myopathies, forming with them a group of myopathies which may be related through a similar biochemical lesion of varying degree. Alternatively, disturbance of mitochondrial functions in a number of myopathies could be considered as a non-specific finding.

Adenosine Diphosphate↗
PubMed1972

Neuroentheric cyst.

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Abnormalities, Multiple↗
PubMedDate not supplied

Estimation of the aging rates of populations through the prevalence of age-related diseases.

Ten prevalences of disease or functional affections due to degenerative processes that statistically show a significant age-dependent behaviour were taken as variables for a biological aging study of a population living in a district of Madrid. The cross-sectional procedure consisted in grouping the disease prevalences by age decades and calculating aging by the vector-analytical mathematical method in which the age-dependent prevalence was the result of one of the total of 10 vector components. The progressive accumulative increase of the vector distances from the origin as well as the distances among the vectors in relation to the population age was considered as biological aging. On the basis of similar mathematical models the results were compared with those obtained from other populations in which different indicators were used; the results are concurrent, but show here a greater aging acceleration than when the population was composed solely of healthy individuals. This is considered a logical consequence due to the sample composition. The presented procedure, focussed epidemiologically, can be useful in comparing aging of populations.

Journal Article↗
PubMedDate not supplied

Increase in insulin secretion with age: its clinical importance in evaluating abnormal secretions focused on diabetes type II and obesity.

The urinary C-peptide excretion was measured in a healthy standardized population sample of 160 subjects from 20 to 90 years of age, homogeneously distributed by age and sex. Urinary C-peptide excretion corresponded to 7% of the total amount released. The daily C-peptide excretion was 61.23 +/- 2.2 (S.E.) microg in the whole sample which corresponds to 41.9 +/- 1.5 IU of insulin secreted/day (I(CP)d), without sex differences. There is an increase of the I(CP)d value from the young to the healthy middle-aged person, but when the results were corrected for standard amounts of excreted creatinine (1 g) and urea (22 g) the age-dependent increase is to be observed during the whole adult life span. Assuming that cross-sectionally observed data are representative of the individual changes, it is concluded that age alone increases insulin secretion. The results which may be useful as reference values for clinical application were as follows: (A) in 5 diabetes type II patients in which the I(CP)d value was measured several times a week, the intraindividual variation coefficient was 10.9 +/- 7.2%;(B) in a sample of 47 type II diabetic patients of both sexes, between 51 and 70 years of age, a clear correlation was found between I(CP)d and the results of the glucagon stimulation test, mainly regarding the relationship between I(CP)d and the planimetrically measured area under the curve (r = 0.7, P < 0.0001); (C) in 7 obese non-diabetic individuals of similar ages the influence of the hypocaloric diet on the I(CP)d value was more evident than the use of C-peptide blood determinations before or after glucagon. Finally, the I(CP)d values of type II diabetes patients with insulin requirement (n = 27) were significantly lower than in the healthy control group (31.1 +/- 24.0 vs. 45.0 +/- 20.4), while diabetic patients without insulin requirement showed significantly higher values (73.0 +/- 33.0) (n = 27). These clinical studies primarily focused on the physiology of human ageing justify the measurement of C-peptide urinary excretion for evaluating daily insulin secretion in patients with type II diabetes.

Journal Article↗
PubMedDate not supplied

[Prognostic value of CAT scanning in spontaneous supratentorial cerebral hemorrhage. Multivariate study in 114 patients].

Prognostic computed tomographic findings for 30-day outcome (survival or death) were retrospectively assessed in 114 patients with spontaneous supratentorial intracerebral hemorrhage. All were treated nonsurgically. CT scans were used to determine location and size of the lesion, presence or absence of intraventricular spread, degree of mass effect and presence or absence of cortical atrophy. Mortality rate was 25.6%. Size of hemorrhage, presence of intraventricular spread and cortical atrophy were multivariately associated with outcome and therefore, acting jointly, contribute substantially to the prediction of outcome. In patients with intraventricular spread who died, age and systolic blood pressure on admission were significantly higher.

Cerebral Hemorrhage↗
PubMedDate not supplied

Determination of citrinin in corn and barley on thin layer chromatographic plates impregnated with glycolic acid.

A method is described for the determination of citrinin in corn and barley. The mycotoxin is extracted with a mixture of acetonitrile-10% glycolic acid in water, defatted with isooctane, and transferred to chloroform according to published methods. The mycotoxin is separated by thin layer chromatography (TLC) on plates previously impregnated with 10% glycolic acid solution in ethanol; identity is confirmed by chemical tests. Citrinin is then quantitated by the limit detection method. Recoveries of citrinin from corn and barley samples spiked at levels of 50, 80, 150, 300, 500, and 1000 micrograms/kg were in the range 91-98%. The minimum detectable concentration is 15-20 micrograms/kg. Recoveries obtained with and without glycolic acid in the extraction solvent were compared. Sensitivities on TLC plates (limits of detection, micrograms/spot) impregnated with glycolic acid were compared with those on plates impregnated with oxalic acid.

Benzopyrans↗