Biomedical subjects
A Gilhar
Publications and source records attributed to A Gilhar.
[The new aspects of Langerhans cells].
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Mast cells in Behçet's disease: ultrastructural and histamine content studies.
In order to assess the role of mast cells in the pathogenesis of mucocutaneous lesions of Behçet's disease, the following investigations were performed: (1) a comparative study of ultrastructural features of mast cells in spontaneous and reactive (pathergic) lesions of the process and in apparently uninvolved skin of patients in the active stage of the disease; (2) comparative estimation of the histamine content at the site of cutaneous hyperreactivity lesions and in apparently uninvolved skin of the same patients. Various forms and degrees of degranulation were revealed among the mast cells. These forms were obviously more frequent in spontaneous and reactive lesions than in the uninvolved skin, 66 and 56% as compared with 7.7%. Also the histamine content was twofold more in the reactive lesions than in the unaffected skin of the same patient, 43 ng/mg tissue as compared with 21 ng/mg tissue. The results of our study seem suggestive of an active role of mast cells in this process. The role is probably similar to that of basophils in cutaneous basophilic hypersensitivity.
Sensitivity to endogenous progesterone. Report of a case.
A patient with a cyclic premenstrual eruption, clearing spontaneously with the menstrual flow, is reported. Hypersensitivity to endogenous progesterone in this case was confirmed by positive intradermal and leukocyte migration inhibition tests. Treatment with conjugated estrogens was followed by remission of symptoms. The importance of awareness to the possibility of progesterone autoimmune mechanisms is emphasized.
Local reaction to subconjunctival injections of MER/BCG.
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[Etiological factors in melanoma].
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[A longitudinal clinical study and laboratory survey of systemic lupus erythematosus].
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The diagnostic problem of Behcet's disease.
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[IgA deficiency in Kaposi's sarcoma].
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Clinical and laboratory criteria for the diagnosis of Behçet's disease.
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[Collagen and Ehlers-Danlos' syndrome].
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[Skin lesions in graft versus host disease].
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Leucocyte migration inhibition in Behçet's disease.
The leucocyte migration inhibition (LIF) was investigated in 16 patients with Behçet's disease, 5 while in the active stage of the process, 3 both during relapse and remission, and 8 during remission of symptoms. In all patients skin tests with various antigens and with a needle prick and physiological saline were simultaneously performed. The results indicate a strong correlation between the activity of the disease, skin reactivity and the reactivity of LIF.
[Cutis marmorata telangiectatica congenita].
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Significance of antibodies to double-stranded DNA in 30 systemic lupus erythematosus patients.
Attention has been directed lately to antibodies reactive with double-stranded DNA (dsDNA) in systemic lupus erythematosus (SLE) patients, as these antibodies are of considerable diagnostic value and are thought to be involved in the pathogenesis of the disease. In the present study, the clinical and laboratory evaluations of 30 SLE patients in various stages of disease activity were correlated with the levels of anti-DNA antibodies, as detected by the methods of Farr and of Aarden et al. Sera of 65 patients in relapse or remission were examined with both techniques, and a discrepancy was found in only nine sera. In addition, in six patients, a differential analysis of the immunoglobulin classes of anti-dsDNA was performed according to the method of Aarden et al. The data obtained with this assay correlate well with SLE activity and thus may add an important step to the evaluation of SLE patients.
Cutaneous manifestations associated with aminoaciduria. Report of two cases.
This is a report of 2 cases revealing photosensitivity in association with aminoaciduria. The first is a patient with psoriasis and the second, a patient with Ehlers-Danlos syndrome, mitis type. The display of the above combinations seems peculiar. The psoriatic lesions become confined mainly to the exposed surface and intermingled with those of photodermatitis forming lesions which are a mixture of the two processes. In the case with Ehlers-Danlos, the disease presented rupioid plaque-like erythematous oozing lesions which seem somewhat different from those of the photodermatosis yet known.
IA induction by gut and epidermal cells of nude mice following administration of human lymphocytes.
Expression of class II molecules by epidermal cells of BALB/c nude mice following an adoptive transfer of lymphoid cells from normal semisyngeneic mice has been previously observed. The purpose of the present study was to determine whether similar expression might be observed after injection of human lymphocytes and to utilize this model to determine whether there would be expression of class II molecules by mucosal and epidermal cells following administration of lymphocytes from young and old donors. In order to address this question, a group of nude mice received a single i.v. injection of human T lymphocytes obtained from aged subjects, and a second group received i.v. injection of lymphocytes from young volunteers. Evaluation of I-A and I-E molecules expression of murine cells were performed by indirect immunoperoxidase staining. More prominent and diffuse staining of class II was observed in the mucosal cells as compared with the keratinocytes. Diffuse and intense staining of intestinal cells was observed mainly in mice treated with lymphocytes from young donors.