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Biomedical subjects

A Gil

Publications and source records attributed to A Gil.

At least 325 records · Page 18Linked to original sources
PubMed1985

Intra-arterial and intravenous chemotherapy for the treatment of malignant glioma. Preliminary results.

Twenty-one patients with malignant glioma were treated with cis-diamminedichloroplatinum II (CDDP II) 60-90 mg/m2 intra-arterial (I.A.) bolus on day 1 and Carmustine (BCNU) 100 mg/m2 intravenously (I.V.) on days 1 and 2. Three patients received additional Aziridinylbenzoquinone (AZQ) 7 mg/m2 (I.V.) on days 1 and 2. At the time of this treatment, seven patients had local recurrence after previous surgery and radiotherapy. Nine patients had subtotal tumor resection or biopsy, one patient had macroscopic tumor resection, and four patients had no previous surgery because of medical contraindication. Six patients received five or more courses of I.A. and I.V. chemotherapy. Five of these patients showed complete remission (CR) and one had a partial remission (PR) by brain computerized tomography (CT scan). Another 15 patients treated with two to four courses of I.A., and I.V. chemotherapy showed eight partial responses (PR), and seven showed no changes (NC) by brain CT scan. Five patients died with disease. Patients who achieved CR also received radical radiotherapy for remission consolidation. Sixteen patients are still alive; five patients are off treatment, four of these with no evidence of disease (NED), one alive with disease (AWD); and the remaining 11 patients are still on treatment. Toxicity, symptomatic neurological recovery, disease stabilization, and causes of death will be discussed.

Adult↗
PubMed1985

Influence of the mother's weight and socioeconomic status on the fatty acid composition of human milk.

The influences of the maternal diet and of the mothers' nutritional and socioeconomic status on the fatty acid composition of human milk have not yet been fully elucidated. Fatty acids from capric (8:0) to docosahexaenoic (22:6w3) acids were determined in 209 samples of human milk obtained from voluntary donors. Samples were classified according to the time of lactation and in relation to the socioeconomic status and to the weight of the lactating women. Capric and lauric acid increased in mature milk while palmitic and stearic acids decreased. Polyunsaturated fatty acids (PUFA) of the w6 and w3 series with more than 18 carbon atoms also decreased from colostrum to mature milk. However, the ratio w3 PUFA/w6 PUFA remained unaltered. Oleic acid decreased in milk from mothers of a medium and low socioeconomic status who consumed almost exclusively seed vegetable oils. The mother's weight did not influence the fatty acid composition of her milk.

Body Weight↗
PubMed1985

The spectrum of neurological manifestations in myeloma.

Thirty-two patients with myelomatosis (3 with a solitary plasmocytoma and 29 with multiple myeloma) and neurological complications, from a group of 110 unselected patients with myelomatous disease were recorded. Spinal cord compression was the most frequent complication seen in 12 cases. In 9 subjects, it was the presenting symptom, and in 11 cases was caused by extradural plasmocytoma of the thoracic spine. Early decompressive laminectomy was curative in 3 cases, but in the rest, delay in diagnosis resulted in only partial recovery even with radiotherapy. Of the 6 patients with nerve root involvement, radiotherapy led to full recovery in 2 of 3 cases, and laminectomy resulted in complete improvement in 2 other cases. Peripheral polyneuropathy was seen in 8 cases, 2 related to systemic amyloidosis and 6 unassociated with amyloidosis. Both forms of neuropathy shared a slow progression, independent of the course of the myeloma. Acute encephalopathy, found in 6 cases, was due to hypercalcemia and/or serum hyperviscosity, and led to a significant shortening of mean survival. One patient had third cranial nerve palsy due to the overlying lesion of the skull base, and another suffered acute bacterial meningitis.

Aged↗
PubMed1984

[Free amino acids of various lacteal formulas used in Spain].

A comparative study has been made upon free amino-acids in human milk, cow's milk and some infant formulas commercialized in Spain. The contents of free amino-acids in human milk is significantly increased when compared to those of raw of UHT sterilized cow's milk and to those of infant formulas. The concentrations of alanine are significantly lower in cow's milk and in infant formulas compared to human milk. The same occurs with branched chain amino-acids, glutamic acid, serine, threonine and taurine. On the contrary, the levels of free cysteine are significantly higher in cow's milk and in infant formulas. The concentrations of free amino-acids determined in different infant formulas on sale in Spain are rather similar between each others, being the cuantitative pattern very different from that determined in human milk.

Amino Acids↗
PubMed1984

[Free amino acid content of human milk in Spain].

The concentrations of free amino-acids have been determined in 54 samples of human milk: 18 in colostrum, 18 in transition milk and 18 in mature milk, all of them taken from women in the Eastern part of Andalucía. The amino-acids have been determined through high pressure ion-exchange chromatography and fluorimetric detection. Glutamic acid is the major free amino-acid, representing 21-52% of the total amount of these components in human milk. Its level increase significantly with advancing lactation. Taurine represents 14-19 of total free amino-acids in human milk, remaining its levels practically unchanged during the whole lactation. The fact that the major content of essential free amino-acids in present in human colostrum could suppose a contribution of these substances which are directly absorbable during a period of life when the nutritional requirements of the neonate are incremented.

Amino Acids↗
PubMed1984

[Lipid profile in low birth weight neonates, small for gestational age].

Serum triglycerides, cholesterol, lipoproteins and fatty acids has been determined in 11 normal infants (RN) and 20 small for date newborn infants (SFD) at birth, before feeding, and at one week of life. All infants were bed with a milk formula (Maseda adaptado ) according with ESPGAN recommendations. Serum triglycerides are significantly increased in SFD after one week of feeding (p less than 0.01). Serum cholesterol in SFD show no differences in relation to normal infants. VLDL are significantly increased in SFD ab birth (p less than 0.01) reaching normal values after one week of feeding. After delivery SFD infants show a low serum level of linoleate (C18:2 omega 6) (p less than 0.05), linolenate (C18:3 omega 3) (p less than 0.02) and eicosadienoate (C20:2 omega 6) (p less than 0.02). No differences are observed in arachidonate (C20:4 omega 6). At one week after feeding no differences are observed in serum fatty acids between SFD and normal infants.

Cholesterol↗
PubMed1984

Urinary 3-methylhistidine derivative as indicator of nutrients intake in low-birth-weight infants.

Urinary excretion levels of N-methylhistidine derivatives and N-methylhistidine/creatinine ratios were studied in a group of 20 small for date newborns, 10 premature infants and 8 normal infants, at birth and at one week of life. All infants were fed with an adapted milk formula supplying 2.8 g protein/kg body weight. 1-methyl and 3-methylhistidine urinary excretion were increased in all groups of infants from birth to the 7th day of life. Creatinine and N-methyl derivatives/creatinine ratios were also significantly increased at one week of life. The two ratios showed a higher level in small for date and premature infants than in normal infants at birth which continued relatively increased at one week of life. 3-methyl-histidine/creatinine ratio appears as a useful indicator of the turnover rate of muscular proteins in low-birth-weight infants.

Body Weight↗
PubMed1984

Changes in serum albumin, transferrin and amino acid indices during the first month of life in small-for-date infants.

Total serum proteins, albumin, albumin/globulin ratio, and plasma-free amino acids have been determined in 12 small-for-date infants and in 14 normal infants at birth, at 1 week and at 1 month after birth. All infants were fed ad libitum with an adapted infant formula providing 1.9 g protein and 74 kcal/100 ml. Total serum proteins and albumin but not transferrin were low at birth in small-for-date infants, reaching normal values after 1 week of feeding. Serum globulins were low from birth to 1 week in small-for-date infants but they were normal after 1 month. Values for classical amino acid malnutrition indices suggest a state of protein-energy malnutrition which disappeared after 1 week of feeding.

Amino Acids↗
PubMed1984

Serum and urine amino acid patterns during the first month of life in small-for-date infants.

Prenatal nutrition is impaired in small-for-gestational-age infants. Serum amino acids may show some biochemical features related to the nutritional state of these children. We have carried out a study on serum and urine amino acids in 12 small-for-date infants (SFD) and 14 healthy newborns from birth to 1 month of life. SFD infants showed a high serum level of alanine and decreased concentrations of branched chain amino acids, aspartate, cystine and tryptophan at birth. The results are compatible with a protein malnutrition state. Levels of serum amino acids in SFD infants showed no differences in relation to normal infants after 1 month of rehabilitation with a diet consisting of an adapted milk formula.

Amino Acids↗
PubMed1984

Fever of unknown origin: a survey on 133 patients.

The hospital records of one hundred and thirty-three patients with fever of unknown origin (FUO) were studied. An etiologic diagnosis had been made in 105 patients: 41 patients had an infection, 24 had a neoplasm, 17 had a connective tissue disease, and 23 had various diseases grouped under "miscellaneous." FUO was self-limiting in 25 of the remaining patients. Invasive procedures (arteriography, biopsy, laparoscopy, paparotomy) were necessary to establish a diagnosis in 67 patients, non-invasive tests (sero-immunologic, bacteriologic, conventional radiologic tests, clinical course and treatment response) were sufficient in 27 patients. In 11 patients, the cause of FUO was determined in necropsy. Thirty patients died of FUO: 6 patients with a neoplasm, 4 with a connective tissue disease, and 7 with diseases termed miscellaneous.

Adolescent↗
PubMed1983

Role of renal gluconeogenesis in the maintenance of glycaemia after L-tryptophan administration to rats.

The time-course of liver and kidney gluconeogenesis after L-tryptophan administration has been studied. Two and half hours after injection of L-tryptophan (0.5 g/kg body wt) a 97% inhibition of hepatic gluconeogenesis in starved rats was observed. Twelve hours later, the inhibition remained 35%. Hepatic glycogen was almost completely depleted (97%) in fed rats after 5 hours. At this time there was a severe hypoglycaemia in fed and 48 h starved rats which gradually disappeared with time, the values going back to normal after 12 hours. Tryptophan treatment was associated with a significant increase in renal gluconeogenesis in fed and 48 h starved rats with a maximum at 5 h (165% and 190% respectively). When hepatic gluconeogenesis was constantly inhibited in fed rats by periodic injection (every 4 h) of L-tryptophan, renal gluconeogenic ability remained increased throughout the experiment while blood glucose concentrations did not change. These observations suggest that kidney contributes to maintain glycaemic homeostasis under these conditions of liver gluconeogenesis impairment.

Animals↗