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Biomedical subjects

A Gibbons

Publications and source records attributed to A Gibbons.

133 records · Page 8Linked to original sources
PubMed1976

Cell-mediated immunity in patients with cystic fibrosis.

Leucocytes from 26 patients with cystic fibrosis (CF) and 18 healthy controls were investigated by migration inhibition induced by a variety of antigens. In patients with CF cell-mediated immunity was found to human lung and pancreatic tissue extracts as well as to Aspergillus fumigatus, Pseudomonas aeruginosa, and food antigens but not to brain, heart, or kidney. Those patients with the severest form of the disease had the greatest impairment of cell-mediated immunity, but this impairment could be reversed by steroid treatment. Cell-mediated cytotoxicity may also be concerned in the pathogenesis of CF.

Adolescent↗
PubMedDate not supplied

Quantitative assessment of changes in aortic dimensions in response to in situ perfusion fixation at physiological pressures.

The study of atherosclerosis often involves evaluation of aortic tissue. The effects of the fixation process on aortic dimensions is and issue of concern. Using aortography we have quantitatively assessed changes in aortic dimensions during in situ perfusion fixation at physiological pressures with 2 commonly used fixative solutions. Two dimensional aortic luminal (TDAL) areas, obtained by planimetry from X-ray images after opaque dye injection (aortography), decreased both early during perfusion fixation and later with cessation of the physiological pressure. These reductions were variable, irrespective of the fixation solution used. Long-term perfusion fixation (10 1/2-12 h) reduced, but did not prevent, changes in TDAL area compared with changes observed following a 1-h perfusion fixation period.

Animals↗
PubMedDate not supplied

Synergistic interaction of cefotaxime and its metabolite desacetylcefotaxime demonstrated by drug-impregnated disks.

Because no simple in vitro test for cefotaxime (CTX) and desacetylcefotaxime (dCTX) synergy exists, and, because no disk susceptibility data is available for dCTX, we investigated the potential of antibiotic impregnated disks as a test for positive in vitro interaction. Results of this study indicate that all strains of Staphylococcus aureus tested demonstrated additive interactions using disks that contained 30 micrograms of dCTX. In contrast, it was necessary to use much smaller concentrations of each cephalosporin to demonstrate additive effects against Gram-negative bacteria. Zones of inhibition were greater for disks containing the combination compared to either CTX or dCTX alone, among all the Gram-negative genera tested; however, these differences were statistically significant only for Klebsiella pneumoniae and Escherichia coli (P less than 0.05). These results demonstrate that disk susceptibility testing is reliable for the CTX metabolite, dCTX, and suggests that this technique using disks impregnated with CTX and dCTX singly and in combination is a simple method with which to evaluate positive antimicrobial interactions in the clinical laboratory.

Cefotaxime↗