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Biomedical subjects

A Giannini

Publications and source records attributed to A Giannini.

At least 73 records · Page 4Linked to original sources
PubMed1986

[Clinical, diagnostic and therapeutic aspects of non-allergic forms of rhinitis: non-allergic rhinitis with eosinophilia syndrome and vasomotor rhinitis].

Two clinical syndromes of non-allergic rhinitis -- NARES and vasomotor rhinitis -- were studied. In recent years there has been a moderate statistical increase in both conditions which are still not easily diagnosed or treated, given the fact that they are often confused with allergic rhinitis. In this context a brief review of aetiopathogenic and physiopathological factors is followed by the suggestion of certain elements that may be assessed in order to obtain a more correct classification and diagnosis. Finally the drugs providing a more effective and long-lasting cure are listed.

Aerosols↗
PubMed1986

[Occupational dermatitis in health care professionals: proposals for its prevention].

Authors have conducted an epidemiological study with regard to dermatitis contracted by health care professional. With this intention they examined approximately 562 cases of dermatitis contracted by contact. From these cases they evaluated the percentage of allergic and irritative forms of dermatitis with primary interest in the inflammatory processes and the principal antigens responsible. In conclusion, they have taken into consideration those which are preventive, environmental and personal interventions which could reduce the incidence of such risk.

Adult↗
PubMed1985

Amanita poisoning: a clinical-histopathological study of 64 cases of intoxication.

In the last few years new and effective therapeutic schedules have been employed in the treatment of patients intoxicated by mushrooms of the genus Amanita. As a result, the survival rate has considerably increased and clinical-histopathological correlation studies, such as the present one, have become feasible. The fate of these patients was once wrongly considered to be either complete recovery (rarely) or death (frequently). According to the results of the present study, Amanita intoxication can also progress to chronic liver damage. This latter evolution of the disease seems to depend on the severity of the acute phase of the intoxication, as clinical, laboratory and biopsy findings of liver alteration testify. The correct evaluation of evolving liver damage involves histopathological investigations, which should be performed 6 months after the acute episode, in those patients who overcome a moderate to severe acute intoxication.

Amanita↗
PubMed1984

Hepatocellular carcinoma and cirrhosis: a review of their relative incidence in a 25-year period in the Florence area.

An eight-fold increase in the incidence of hepatocellular carcinoma in the Florence area was detected in a 25-year retrospective review of adult autopsy records in the Institute of Pathology of the University of Florence. During the same period, the incidence of cirrhosis did not show a parallel increase. The relationship between hepatocellular carcinoma, cirrhosis and HB virus is briefly discussed in the light of these findings.

Adult↗
PubMedDate not supplied

The availability of histologic grading among 5,923 Italian cancer patients and its relationship with survival: a population-based study.

AIM: The specific goal of the study was to evaluate the availability of the histologic grading of cancer and its effect on survival in an Italian population-based cancer series. METHODS: Data were drawn from the Tuscany Cancer Registry, active in central Italy since 1985. Among the cases incident during the period 1985 to 1989, bladder, prostate, colon, corpus uteri, rectum and stomach cancers, for which the proportion of graded cases exceeded 50%, were analyzed. Overall, 5,923 cancer cases were included. Ten-year relative survival rates by grade were computed. RESULTS: Overall, data on histologic grading was available only for 38% of cases. The sites most frequently graded were urinary bladder (80%), prostate (73%), colon (71%), corpus uteri (69%), rectum (65%) and stomach (56%). For all the cancer sites analyzed, the 10-year relative survival rates increased as the histologic grading improved. The grade distribution resulted related also to the disease extension, more limited the extension higher the proportion of well differentiated cases. CONCLUSIONS: Due to the evidenced importance of histologic grading as a valuable prognostic factor, it should be requested by clinicians and reported by pathologists more frequently than has been done in the area.

Adult↗
PubMedDate not supplied

[General anesthesia for magnetic resonance. Experience on 100 cases].

The diffusion of magnetic resonance imaging as a powerful non-invasive diagnostic procedure has led to an increasing request for general anaesthesia in patients who cannot lie still and/or who cannot guarantee adequate spontaneous breathing during the procedure. We report our own experience in 100 patients of this kind, in whom the need for general anaesthesia was due to neurological problems and/or tender age. Anaesthesia and monitoring devices were either devoted of ferromagnetic properties (allowing their location near the patient; as the ARM-S88 portable ventilator, which we used for adult patients) or connected to the patient with long connectors (allowing their location outside the resonance magnetic field; as the Draeger-Babylog pressometric ventilator, which we used in pediatric patients). On these bases administration of intravenous (86 patients) and inhalation (14 patients) anaesthesia during magnetic resonance proved safe in our experience.

Anesthesia, General↗
PubMedDate not supplied

[Histopathological parameters and lymphatic metastasis in supraglottic laryngeal carcinoma].

Histopathologic parameters in predicting lymph node metastasis of supraglottic laryngeal carcinoma. A systematic clinical-pathological study was performed on fifty-three resected cases of supraglottic laryngeal squamous cell carcinoma, followed up for at least 5 years. The aim of the research was to evaluate histopathologic parameters in predicting lymph node metastasis (N+) as expression of biological malignancy of the neoplasm. The following neoplastic microscopical features were studied: histopathologic and cytologic grading, pattern of growth, peritumoral inflammatory infiltrate, stromal reaction, tumoral necrosis. The results are as follows: stromal reaction and cytologic grading are not useful to identify N+ and N- cases. Cases with high and low degree of differentiation (Broder's grading) are significantly correlated respectively to low (14.3%) and high (70%) incidence of lymph node metastasis (p less than 0.03). A clear correlation is present between the pattern of growth "pushing" and lacking of node metastasis (84.6%). A favorable prognosis significance seems to be linked with the presence of peritumoral lymphoplasmocytic infiltrate, which results to be a marker of cases in which lymph node metastasis incidence is very low (5.5%; p less than 0.001). On the contrary lymph node metastasis incidence increase when tumoral necrosis is present (76.5%; p less than 0.001).

Carcinoma, Squamous Cell↗
PubMedDate not supplied

[Histologic analysis of intraepidermal melanocytic proliferation in the peripheral area of superficially diffused melanoma].

Histological analysis of intraepidermal melanocytic proliferation in the peripheral areas of superficial spreading melanoma. The intraepidermal melanocytic proliferation in the areas adjacent to the invasive component of 100 superficial spreading melanomas of the skin (levels III and IV) was studied. Three patterns were identified: 1) melanoma in situ type (MIS); 2) melanocytic dysplasia type (DYS); 3) normal skin or increased number of typical melanocytes (0). The different distribution of these patterns in the areas adjacent to the invasive melanoma led to a histological classification of the tumors into 4 topographical models. Two models showed MIS areas and contiguous normal skin (A1, A2); two models showed MIS areas adjacent to DYS areas, that in turn were contiguous to normal skin (B1, B2). In all cases, however, in centrifugal sense, more severe alterations preceded less severe ones. These observations suggest that superficial spreading melanoma grows horizontally by induction of neighbour cells (neoplastic recruitment). The neoplastic transformation seems to progress in two ways: directly to melanoma in situ or through an intermediate phase (melanocytic dysplasia).

Cell Division↗