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Biomedical subjects

A Giangrande

Publications and source records attributed to A Giangrande.

At least 73 records · Page 4Linked to original sources
PubMed1985

Continuous venous-venous hemofiltration for the treatment of fluid overload in continuous ambulatory peritoneal dialysis patients.

Fluid overload is not infrequent in continuous ambulatory peritoneal dialysis (CAPD) patients. In our experience, extemporaneous continuous venous-venous hemofiltration (CVVHF) was able to correct fluid imbalances refractory to high dose diuretics and hypertonic solutions. We treated 8 of 52 patients (5 females, 3 males, mean age 52 years) on CAPD from 4 to 36 months and with fluid overloads of up to 10 kg. A Biospal SCU/CAVH flat-sheet high-flux hemodialyzer employed for 10 h produced an ultrafiltration rate (QB:150 ml/min) of 11.12 +/- 4.97 ml/min. With an isotonic replacement solution, the filter provided sufficient extraction of small molecules so that CAPD could be interrupted during CVVHF. The procedure appeared well tolerated. This approach reduced the use of hypertonic dialysate, which is not devoid of side effects on ultrafiltration capacity of the peritoneal membrane.

Adult↗
PubMed1985

Electron microscopy and microprobe analysis of dialysis contaminants.

A migration of plastic particles from haemodialysis circuit to blood has been recognized to be cause of storage inflammation. Its origin from segments of silicone tubing has been demonstrated by in vivo and in vitro experiments. A similar finding with a peculiar histology picture has been observed in patients who used only PVC and PU-PVC tubing. In this case too microprobe analysis revealed the presence of silicon (Si) in fibril inclusions of liver and spleen cells. TEM, SEM and EDS of cuprophane dialyzer perfusates filtered through Nuclepore revealed the presence of particles with an intense Si Ka. The release from the dialyzer of silicon containing contaminants seems to be an additional risk for uremic patients.

Adult↗
PubMed1985

Ultrasonically guided fine-needle alcohol injection as an adjunct to medical treatment in secondary hyperparathyroidism.

In 12 uraemic patients with symptomatic secondary hyperparathyroidism, 13 parathyroid hyperplasias, detected by sonography and confirmed by fine-needle aspiration biopsy, were treated by ultrasonically-guided percutaneous injection of absolute ethanol, in order to reduce the gland mass. Only in the larger glands were significant volume reductions recorded, whereas in the smaller ones evident structural changes were observed. In most cases with single lesions, a reduced incidence of vitamin D hypercalcaemia and a permanent improvement in bone alkaline phosphatase and PTH were documented. This technique can be usefully employed either as an alternative to surgery in selected cases, or as support to medical therapy in single lesions.

Ethanol↗
PubMed1983

Parathyroid tumors detected by fine-needle aspiration biopsy under ultrasonic guidance.

Ultrasonically-guided fine-needle aspiration biopsy of 52 suspected parathyroid tumors was performed in 42 patients with primary or secondary hyperparathyroidism. Evidence of a parathyroid tumor was detected cytologically in 31 cases; in 14 the lesion could be attributed to the thyroid gland, while in 7 the aspirated material was inadequate. This technique proved to be extremely helpful in differentiating parathyroid tumors from thyroid nodules and in identifying parathyroid lesions having an atypical location or echo pattern.

Adenoma↗
PubMed1983

Continuous ambulatory peritoneal dialysis and cellular immunity.

E+-cells were studied in 16 patients on continuous ambulatory peritoneal dialysis (CAPD) to evaluate the impairment of cell-mediated immunity. E-rosette forming cells (E-RFC) were below the normal range at the beginning of treatment in 10/16 patients, after which their number increased and reached normal levels in the majority of patients in three to six months. In this phase of therapy, the same result was obtained with OKT11 monoclonal antibody, while OKT+4/OKT+8 ratio was in the normal range. Normal human lymphocytes, pre-incubated with uraemic peritoneal fluid, showed a significant reduction of E-RFC. Maximum inhibition was observed with the less than 500 daltons fraction of peritoneal fluid. Extraction with chloroform almost completely abolished inhibitory activity, suggesting that the toxic substance(s) has the characteristic of a polar lipid. Immunodeficiency in CAPD patients seems therefore partly restored by the removal through the peritoneum of inhibitors capable of blocking sheep-cell receptors.

Adolescent↗
PubMed1983

Parathyroid ultrasonography and fine-needle aspiration biopsy in the diagnosis of secondary hyperparathyroidism.

Parathyroid tumours were sonographically detected in 24 out of 72 uraemic patients with clinical and biochemical findings of secondary hyperparathyroidism. In 12 out of 24 cases ultrasonically guided fine-needle aspiration biopsy of the tumours was performed in order to obtain a cytological specimen. In the eight patients who subsequently had surgical exploration of the neck, diagnostic accuracy of both ultrasonography and biopsy combined was 87 per cent.

Biopsy, Needle↗
PubMed1978

Isocitrate dehydrogenase in Aedes aegypti: formal genetics, preliminary linkage data and study of natural populations.

Two loci for isocitrate dehydrogenase (Idh-1 ad Idh-2) are described in Ae. aegypti, both polymorphic with two codominant alleles. Crosses made to test linkage relationships of Idh-1 indicate that this locus is independent from sex (chromosome 1) and from Sod-1 and Hk-1 loci (chromosome 3), while it is linked to Pgm on the second chromosome. Average percent of recombination is 11.37, but significant differences have been found among strains. Data on genetic variability of Idh-1 and Idh-2 in three domestic african field populations are presented.

Aedes↗