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Biomedical subjects

A Ghiselli

Publications and source records attributed to A Ghiselli.

49 records · Page 3Linked to original sources
PubMed1985

Relationship between platelet cyclooxygenase pathway and plasma malondialdehyde-like material.

Thrombin-induced platelet malondialdehyde (MDA) formation and plasma malondialdehyde-like material (MDA-LM) were evaluated in 12 healthy subjects before and after 1 and 7 days from aspirin (1 g) ingestion. 24 hr after aspirin administration, platelet MDA was almost abolished while MDA-LM showed a 23% decrease. Platelet MDA and plasma MDA-LM returned to baseline values 7 days after aspirin ingestion. These data suggest that platelet cyclooxygenase pathway affects only in part plasma MDA-LM. The evaluation of plasma MDA-LM before and after aspirin could be useful for evaluating in vivo platelet cyclooxygenase activation.

Adult↗
PubMed1985

Blood lipid profile in healthy subjects treated with ticlopidine.

The study was carried out in order to evaluate if Ticlopidine induces lipid metabolism changes. Twenty seven healthy subjects were studied, 14 with placebo and 13 with Ticlopidine treatment (500 mg/day), for 30 days. Total cholesterol, HDL cholesterol, triglycerides, apolipoproteins A and B were evaluated before and after treatment. No significant changes of the blood lipid parameters were observed.

Adult↗
PubMed1985

A simple method for evaluating platelet superoxide dismutase.

A simple and rapid spectrophotometric method for evaluating platelet superoxide dismutase is reported. Platelets prepared avoiding erythrocyte and leucocyte contamination were lysated and tested in a Tris-cacodylic buffer containing pyrogallol. Platelet superoxide dismutase was calculated by evaluating the degree of the pyrogallol autoxidation inhibition induced by platelet lysate. Possible interferences of hydrogen peroxide, peroxidases and reducing substances were excluded. Platelet superoxide dismutase content was studied in 38 healthy subjects and was 19.1 +/- 4.1 U/10(8) platelets or 35 +/- 7.8 U/mg protein.

Adolescent↗
PubMed1985

[Aortic coarctation with hypoplasia of the arch: description of a new surgical technic].

The aortic coarctation is frequently associated with aortic arch tubular hypoplasia, especially in early infancy. The treatment in one time of both lesions is mandatory in these cases. We propose therefore a new surgical technique: after resection of the isthmic coarctation and appropriate cutting of both ends, the anastomosis is widely extended in the concavity of transverse aortic arch, beyond the hypoplastic region. We discuss the advantages of this technique over the classic end-to-end anastomosis, patch graft and subclavian flap angioplasty.

Aorta, Thoracic↗
PubMed1984

Influence of vitamin E on plasma malondialdehyde-like material in man.

The behaviour of plasma malondialdehyde-like material (MDA-LM) was evaluated in 13 healthy subjects by a single-blind study that consisted of placebo (30 days), vitamin E treatment (300 mg/day) (30 days) and placebo (30 days). The study demonstrated that MDA-LM did not change during placebo treatment while it significantly decreased after vitamin E administration.

Adolescent↗
PubMed1982

Effects of ticlopidine on platelet function and blood coagulation.

A double blind study was performed on 20 atherosclerotic patients. A placebo was administered to one group of 10 patients (group A) and ticlopidine (500 mg/day) was administered to another group of 10 patients (group B) for one month. ADP and collagen-induced platelet aggregation (PA), platelet malondialdehyde (MDA) produced by thrombin stimulation and plasma beta-thromboglobulin (beta TG) levels, prothrombin time, activated partial thromboplastin time (APTT) fibrinogen, antithrombin (AT) III fibrin(ogen) degradation products, alpha 2-antiplasmin and plasminogen were evaluated in both groups before and after treatment. No changes in PA, MDA and beta TG were seen in group A. Group B showed a significant decrease of PA, beta TG and a significant increase of MDA. No changes on blood coagulation data were seen in either group. This study suggests that ticlopidine is able to inhibit platelet function in vivo.

Adult↗
PubMedDate not supplied

[Determination of the blood ascorbic acid level after administration of slow-release vitamin C].

PURPOSE: The aim of the present study was to test the effects of a slow releasing form of vitamin C in smokers, because the single high dose previously proposed for smokers gave a transient increase of plasma ascorbate, being rapidly absorbed in the gastrointestinal tract and is rapidly excreted with urine. MATERIALS AND METHODS: In a double-blind placebo-controlled study 18 subjects received both Vitamin C (C-test) and placebo (P-test) in two different periods. During the test-day the subject followed a controlled diet and food Intake was assessed by semiquantitative questionnaire. Peripheral blood sample were collected in fasting conditions, in the morning, before and after 4, 8, 12 and 24 hours from the treatment. Blood sample was collected into EDTA-containing tubes, immediately centrifuged and treated for ascorbate determination, and stored at -70 degrees C until chromatographic analysis. RESULTS: Smokers and nonsmokers were similar for age, height, weight, BMI and for vegetable and fruit consumption. Ascorbic acid level was significantly (p < 0.05) lower than the references level in all subjects, however there were no differences between smokers and non smokers plasma ascorbate concentration increased significantly at T1, T2 and T3 respect to T0 during C test (p < 0.005), whenever remaining higher than T0 was not still significant in T4. CONCLUSION: Our results demonstrate that a slow releasing form of Vitamin C could be useful in clinical pharmacology to increase and to maintain to a constant rate ascorbate level, both in smokers and non smokers with a single daily administration.

Adult↗
PubMedDate not supplied

Surgical treatment of anomalous origin of the left coronary artery in infancy.

Two cases of anomalous origin of the left coronary artery (LCA) from the pulmonary artery (PA) are reported in which early surgical correction was achieved by an end-to-end anastomosis of the left subclavian artery (LSA) to the LCA, with cardiopulmonary bypass and deep hypothermia. The clinical improvement was rapid and the left ventricular function recovered almost completely. We recommend this type of surgical correction, early in life, for infants in severe cardiac failure and anomalous origin of the LCA.

Anastomosis, Surgical↗