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Biomedical subjects

A Germenis

Publications and source records attributed to A Germenis.

29 records · Page 2Linked to original sources
PubMed1984

Genetic markers in carcinoma of the prostate.

The distribution of phenotypes and gene frequencies of the third component of complement (C3), group-specific component (Gc), haptoglobin (Hp) and transferrin (Tf) were studied in 115 patients with carcinoma of the prostate. The statistical analysis of our findings in comparison to the frequency of these genes in a control group of 155 patients with benign prostatic hyperplasia does not reveal any correlation between the distribution of the Hp and Tf phenotypes and the disease. On the contrary, a statistically significant association was found between carcinoma of prostate and C3F and Gc2 genes. The relative risk incidence of this malignancy is 1.56 and 1.81, respectively, for the carriers of these genes suffering from benign prostate hyperplasia.

Complement C3↗
PubMed1983

[Genetic markers in benign hypertrophy of the prostate].

The distribution of phenotypes and gene frequencies of the C3 component of complement, group-specific component, transferrin and haptoglobin were studied in 155 patients with benign prostatic hyperplasia. A statistical analysis of the findings in comparison with the frequency of these genes in the general population failed to demonstrate any correlation between phenotype distribution and benign prostatic hyperplasia.

Complement C3↗
PubMed1983

A simultaneous study of the polymorphism of five proteins in the serum and the urine of nephrotic patients.

The phenotypes of the haptoglobin (Hp), ceruloplasmin (Cp), group-specific component (Gc), transferrin (Tf), and third component of complement (C3) were determined simultaneously in the serum and urine of patients with proteinuria secondary to nephrotic syndrome of various types. In a large number of cases the patterns of Hp, Cp, and C3 phenotypes in the urine showed marked deviations from those in the corresponding serum either in the mobility or the number of their electrophoretic bands. The monomeric Hp and the Cp were found to have a very augmented urine/serum ration in some cases. Such differences were not detected in the electrophoretic appearance of the Gc and Tf phenotypes. Our results imply that in the proteinuria of the nephrotic syndrome, factors other than molecular weight interfere in the passage of proteins through the glomerular wall.

Adolescent↗
PubMed1983

[Genetic markers in papillary cancer of the bladder].

The distribution of the phenotypes and the gene frequency of the 3rd fraction of complement (C3), the specific group (Gc), haptoglobin (Hp) and transferrin were studied in 133 patients with transitional cell cancer of the bladder (papillary cancer). Statistical analysis of these results, in comparison with the frequency of these genes in the general population, was unable to demonstrate a correlation between the distribution of these phenotypes and papillary cancer.

Carcinoma, Papillary↗
PubMedDate not supplied

Serum protein markers (Hp, GC, C3) in patients with colon cancer.

The phenotypes and gene frequencies of three serum protein systems--Hp, GC and C3--were studied in 184 consecutive patients from all over Greece with colon cancer. Healthy Greeks studied previously in our department served as controls. No significant differences were found between patients and controls concerning GC and C3. Significant differences were found in the Hp system; the frequencies of the Hp*1 gene and the Hp 1-1 phenotype were significantly higher in patients than in controls.

Adult↗
PubMedDate not supplied

Latent cytomegalovirus (CMV) infections affect immunoglobulin levels of patients with thalassemia major.

The serum levels of IgG, IgA and IgM were measured by radial immunodiffusion in 247 patients with beta-thalassemia major (106 nonsplenectomized and 141 splenectomized) aged between and 5 and 35 years, and in 407 healthy controls. The results were analyzed in relation to the presence of total and/or IgM antibodies against CMV in the sera, as determined by enzyme immunoassay. A statistically significant variation in IgM levels was observed between the seronegatives and the different groups of seropositives (those with recent and those with prior CMV infections) within nonsplenectomized and splenectomized thalassemic patients, as well as within controls. Among seronegative individuals, no significant differences in the levels of immunoglobulins were observed, either between nonsplenectomized and splenectomized thalassemics or between each one of these groups and the controls. On the contrary, when the above mentioned groups of patients and controls appeared with recent or old CMV infections, they presented significantly different levels of immunoglobulins. It is concluded that latent CMV infections are responsible, at least in part, for the disagreement between various published studies concerning the levels of circulating immunoglobulins in patients with thalassemia major.

Adolescent↗
PubMedDate not supplied

Complement activation in atherosclerosis: effect of angiography and surgery.

Complement activation in the plasma of patients with severe atherosclerosis (arterial occlusive or aneurysmatic disease) was investigated in this study. The effects of angiography and reconstructive arterial surgery (RAS) were also assessed. Atherosclerosis was not found to be associated with systemic complement activation. Angiography resulted in high levels of C3 breakdown products. Surgery caused a significant degree of systemic complement activation in both patients with atherosclerosis and controls. Post-operative levels of C3 breakdown products were significantly higher in atheromatic patients than in controls, most likely due to the insertion of dacron arterial prostheses in the first group.

Angiography↗