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Biomedical subjects

A Gergely

Publications and source records attributed to A Gergely.

At least 55 records · Page 3Linked to original sources
PubMed1982

Serum nickel concentration in women during pregnancy, during parturition, and post partum.

Concentrations of nickel (Ni) were measured by atomic absorption spectrophotometry in serum collected from 67 women divided into five groups: (1) healthy control subjects; (2) third-trimester pregnancy (32 to 36 weeks); (3) parturition; (4) post partum 1 (5 minutes); (5) post partum II (60 minutes). In the pregnant group, the serum level of Ni was lower by 60% than that in either the control or parturient group. A significant twenty-fold elevation in the concentration of nickel was observed immediately after delivery of the infant but before delivery of the placenta. Sixty minutes after parturition, the serum concentration of Ni was again similar to the control value. The possible physiologic significance of transient hypernickelemia in the advanced stage of human labor may be related to the support of placental separation and/or to the prevention of atonic bleeding.

Adolescent↗
PubMed1980

[Supply of some essential trace elements to the Hungarian population].

The authors determined the copper, zinc, chromium, cobalt, manganese, iron and nickel contents in 703 samples of animal foods (meat, offals, milk, eggs) from different parts of Hungary and of 370 samples of fruits and vegetables. Calculations based on consumption data from the Central Board of Statistics showed that the copper and iron intakes of the population are lower than those suggested the FAO/WHO. When infants are given exclusively ready-to-use baby foods produced on a milk-only basis (Hungarian products and products imported from western countries), their supply is still less favourable than that to adults. Whereas human milk meets also the requirements of trace elements optimally, ready-to-use baby foods produced on a milk-only basis supply not more than 10--15% on the required copper and 20--35% of the required iron. The authors focus attention on the risk of inadequate supply of trace elements in childhood, the negative implications of which will still manifest themselves in adulthood for a long time.

Animals↗
PubMed1979

Hepatic metabolism in ethanol-treated young rats.

Dams of a Wistar-derived OETI strain were offered a 15% aqueous ethanol solution as drinking-fluid immediately after delivery until weanling. Their offsprings also received the same drinking-fluid from weanling (Group A). Another group of rats received the 15% aqueous ethanol solution only after weanling (Group B). In response to ethanol treatment the retardation of growth was the most marked in Group A, but the growth of rats in Group B was also decreased significantly as compared to that of controls. Hepatic glycogen content was diminished in all of the ethanol-treated groups. Triglyceride content was increased in the livers of female rats in Group A. By comparing earlier results with the present findings the authors point to the importance of strain and sex in experiments when parameters for hepatic metabolism are studied in response to ethanol.

Animals↗
PubMed1979

Metabolic effects of ethanol in the rat liver.

The NADPH is one of the cofactors in ethanol metabolism. The aim of the study was to investigate the effect of ethanol on a NADPH generating enzyme (G6P-DH) and on some metabolic parameters of the liver. After a 2-day starvation period rats were fed a lipid free diet for three days. During this refeeding period the animals were divided into three groups; they received a single daily dose of 4 g per kg b.w. ethanol, isocaloric aqueous glucose solution or water by gastric tube. In response to ethanol the activity of hepatic G6P-DH decreased. The amount of triglyceride remained unchanged, certain changes occurred in the fatty acid composition of total lipid. The liver glycogen content was elevated. In female rats treated with ethanol the activity of glucose-6-phosphatase increased.

Animals↗
PubMed1979

Effect of ethanol on certain metabolic pathways in young R/Amsterdam rats.

R/Amsterdam rats were offered a 15% aqueous ethanol solution as drinking fluid from delivery via the milk (Group A) or from the weanling (Group B). Ethanol treatment resulted in a significant retardation of growth in both Groups A and B compared to controls (Group C); the changes were more marked in Group A. Female rats responded to ethanol with higher increase of microsomal G6P-ase and mixed function oxygenase activities than males subjected to the same treatment. Hepatic triglyceride, glycogen and protein contents remained unaffected by ethanol. There was no difference in the changes of liver metabolism between Groups A and B either receiving ethanol already from birth via the milk or only after weanling.

Animals↗
PubMed1978

Complexes of sulfur-containing ligands. I. Factors influencing complex formation between D-penicillamine and copper (II) ion.

Complex formation and redox reactions between copper (II) ion and D-penicillamine were studied in detail as functions of the metal/-ligand ratio and the concentration of halide ions. It was established that a copper (I)- D-penicillamine polymeric complex of amphoteric character is formed when excess D-penicillamine is present. When the D-penicillamine/copper (II) ratio = 1.45 in the starting reaction mixture, a mixed valence complex with an intense red-violet color is formed. The formation of this compound, which contains 44% copper (II) ion, is greatly influenced by the experimental conditions, primarily by the concentration of halide ions. The main chemical and physical characteristics of the mixed valence complex were determined via magnetic and spectroscopic measurements. It was further established that a very intense blue complex is formed when the D-penicillamine/copper (II) ratio = 2 and halide ions are present. On the basis of the nature of the products formed under various conditions it was concluded that the copper (II)-D-penicillamine system may serve as a good model for studying the binding sites of copper-containing proteins.

Cations, Divalent↗
PubMed1978

[Anticonvulsive treatment and calcium metabolism].

In 31 children (12 boys and 19 girls), who were treated with at least two anticonvulsants, the calcium metabolism was followed for 2 years. Eight boys and 5 girls (13 cases) showed increased serum calcium and/or alkaline phosphatase values. Administration of vitamin D3 for a period of 3 months resulted only in partial regulation of hypocalcemia in boys, but had no effect whatsoever upon the alkaline phosphatase level. With the boys, the percentage of cases of disturbance of calcium metabolism was higher than with the girls. Roentgenologically detectable changes in long, tubular bones (especially the femur and tibia) could be observed in 6 patients. Among 200 consecutive roentgenograms available to the authors' laboratory, similar pictures were discovered in 3 patients. Two of them were not suffering from epilepsy, while one female patient had been taking antiepileptic drugs for 9 months only. The authors emphasize the importance of making laboratory examinations already before the commencement of antiepliptic medication.

Adolescent↗
PubMed1977

Determination of mercury in fish from rivers and lakes in Hungary by atomic absorption technique.

In 1975, in cooperation with 8 County Hygienic Stations, total mercury content in fish from rivers and lakes in Hungary was measured. The mercury content in fish muscle-tissue from 164 fish samples averaged 0.36 mg/kg. Average levels in different fish species ranged from 0.10 to 0.57 mg/kg. The amount of mercury in fish from rivers and lakes, with the exception of the Danube, was, in general, lower than the tolerance level (0.50 mg/kg) as adopted in many countries. Mercury levels in fish from Lake Balaton did not amount to more than 0.30 mg/kg. The circulating cold vapour atomic absorption method was used to determined the mercury content in the fish samples.

Animals↗