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Biomedical subjects

A Gerard

Publications and source records attributed to A Gerard.

At least 91 records · Page 5Linked to original sources
PubMed1982

Electrophysiological evidence for a possible serotonergic involvement in some endogenous opiate activity in humans.

The effects of indalpine (a selective 5-HT uptake inhibitor) on the threshold of lower limb nociceptive flexion reflexes were studied (double blind) in humans. After 3 days' administration, indalpine was found to exert a significant naloxone-reversible depression (threshold increased) of the nociceptive reflexes (naloxone and saline were tested double blind). In contrast, no change was found during treatment with placebo. The functional and therapeutic implications of these results are discussed.

Adult↗
PubMed1982

[Not Available].

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France↗
PubMed1980

Impairment of skin graft take after CO2 laser surgery in melanoma patients.

Twenty-four patients presenting with primary malignant melanoma of the skin (stage 1) were submitted to wide excision of the tumour, followed by immediate split-skin grafting. In 12 patients a CO2 laser was used to excise the melanoma and only 1 of these patients had a 100 per cent skin graft take, while 9 out of 12 patients whose melanoma was exercised with a conventional scalpel had a 100 per cent take. It is concluded that skin excision with the CO2 laser impairs subsequent skin graft take.

Adult↗
PubMed1978

Clinical trials on gastrointestinal cancer in Western Europe and in the FORTC.

The therapeutics on gastrointestinal cancer including only randomized clinical trials carried out in Western Europe and in the EORTC are reported. The studies on preoperative radiotherapy in resectable esophagus cancer and on chemotherapy associated to radiotherapy in nonresectable esophagus cancer has just been activated. The data of a trial on the treatment of gastric cancer have demonstrated the efficacy of long term 5-FU administered after postoperative irradiations. A trial on the immunostimulating effect of levamisole as adjuvant treatment of colon cancer is described, as well as the results of chemotherapy in advanced colon cancer. Finally, scribed, as well as the results of chemotherapy in advanced colon cancer. Finally, the preliminary results of two European trials studying the effect of preoperative radiotherapy and of a chemotherapy, used as a preoperative irradiation sensitizer in rectal cancer, are commented on.

Antineoplastic Agents↗